Remyelination therapies: a new direction and challenge in multiple sclerosis

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

(2017) Diego Cadavid et al.   LANCET NEUROLOGY

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

(2017) Paolo A. Muraro et al.   JAMA Neurology

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

(2017) Eva María Medina-Rodríguez et al.   Scientific Reports

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination

(2016) Abbe H. Crawford et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

(2016) Benedetta Bodini et al.   ANNALS OF NEUROLOGY

A new in vitro mouse oligodendrocyte precursor cell migration assay reveals a role for integrin-linked kinase in cell motility

(2016) Ryan W. O’Meara et al.   BMC NEUROSCIENCE

Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study

(2016) Iris D. Kilsdonk et al.   BRAIN

Monitoring multiple sclerosis by multimodal evoked potentials: Numerically versus ordinally scaled scoring systems

(2016) Regina Schlaeger et al.   CLINICAL NEUROPHYSIOLOGY

Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release

(2016) Sigrid Koudelka et al.   CURRENT BIOLOGY

A mouse model for testing remyelinating therapies

(2016) C. Brian Bai et al.   EXPERIMENTAL NEUROLOGY

The molecular physiology of the axo-myelinic synapse

(2016) Ileana Micu et al.   EXPERIMENTAL NEUROLOGY

Assessing remyelination - metabolic labeling of myelin in an animal model of multiple sclerosis

(2016) Rina Aharoni et al.   JOURNAL OF NEUROIMMUNOLOGY

Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study

(2016) Caryl J. Schwartzbach et al.   JOURNAL OF NEUROLOGY

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination

(2016) Feng Mei et al.   JOURNAL OF NEUROSCIENCE

Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial

(2016) Harold L Atkins et al.   LANCET

Demyelination induces transport of ribosome-containing vesicles from glia to axons: evidence from animal models and MS patient brains

(2016) Antos Shakhbazau et al.   MOLECULAR BIOLOGY REPORTS

Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types

(2016) Yunyan Zhang et al.   Multiple Sclerosis Journal

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

(2016) Mariana Rinaldi et al.   NEUROBIOLOGY OF DISEASE

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

(2016) Stephanie A. Redmond et al.   NEURON

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

(2016) Frédéric Sedel et al.   NEUROPHARMACOLOGY

Imaging as an Outcome Measure in Multiple Sclerosis

(2016) Daniel Ontaneda et al.   Neurotherapeutics

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Activity-Dependent and Experience-Driven Myelination Provide New Directions for the Management of Multiple Sclerosis

(2016) Samuel K. Jensen et al.   TRENDS IN NEUROSCIENCES

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

(2016) Changsheng Du et al.   Nature Communications

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types

(2016) Yunyan Zhang et al.   Multiple Sclerosis Journal

MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study

(2016) Ayman Tourbah et al.   Multiple Sclerosis Journal

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system

(2016) Ginez A. Gonzalez et al.   Scientific Reports

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination

(2015) Yasir A. Syed et al.   ACTA NEUROPATHOLOGICA

Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination

(2015) Anna Preisner et al.   ACTA NEUROPATHOLOGICA

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation

(2015) Alerie Guzman de la Fuente et al.   JOURNAL OF CELL BIOLOGY

Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis

(2015) Simon Zhornitsky et al.   Journal of Neuroinflammation

Apoptosis of Oligodendrocytes during Early Development Delays Myelination and Impairs Subsequent Responses to Demyelination

(2015) A. V. Caprariello et al.   JOURNAL OF NEUROSCIENCE

Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair

(2015) K. Abiraman et al.   JOURNAL OF NEUROSCIENCE

Thyroid Hormone Potentially Benefits Multiple Sclerosis via Facilitating Remyelination

(2015) Mao Zhang et al.   MOLECULAR NEUROBIOLOGY

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

(2015) Sigrid Mensch et al.   NATURE NEUROSCIENCE

Neuronal activity biases axon selection for myelination in vivo

(2015) Jacob H Hines et al.   NATURE NEUROSCIENCE

Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720)

(2015) A. Yazdi et al.   NEUROSCIENCE

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

High doses of biotin in chronic progressive multiple sclerosis: A pilot study

(2015) Frédéric Sedel et al.   Multiple Sclerosis and Related Disorders

Early netrin-1 expression impairs central nervous system remyelination

(2014) Vanja Tepavčević et al.   ANNALS OF NEUROLOGY

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Direct and Indirect Effects of Immune and Central Nervous System–Resident Cells on Human Oligodendrocyte Progenitor Cell Differentiation

(2014) Craig S. Moore et al.   JOURNAL OF IMMUNOLOGY

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis

(2014) Spencer M. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

(2014) Iben Lundgaard et al.   PLOS BIOLOGY

Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients

(2014) Robert A. Brown et al.   NeuroImage-Clinical

Full-Length and Fragmented Netrin-1 in Multiple Sclerosis Plaques Are Inhibitors of Oligodendrocyte Precursor Cell Migration

(2013) Jenea M. Bin et al.   AMERICAN JOURNAL OF PATHOLOGY

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis

(2013) Damineh Morsali et al.   BRAIN

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

(2013) Josephine M. J. Stoffels et al.   BRAIN

Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology

(2013) Fernando de Castro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis

(2013) Khalil S. Rawji et al.   Clinical & Developmental Immunology

Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo

(2013) Tim Czopka et al.   DEVELOPMENTAL CELL

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

(2013) Jason R. Plemel et al.   GLIA

Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

(2013) H. A. Petrosyan et al.   JOURNAL OF NEUROSCIENCE

Myelin Loss Does Not Lead to Axonal Degeneration in a Long-Lived Model of Chronic Demyelination

(2013) C. M. Smith et al.   JOURNAL OF NEUROSCIENCE

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Estrogen receptor (ER)   expression in oligodendrocytes is required for attenuation of clinical disease by an ER  ligand

(2013) A. J. Khalaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

Cortical remyelination: A new target for repair therapies in multiple sclerosis

(2012) Ansi Chang et al.   ANNALS OF NEUROLOGY

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

LINGO-1, a Transmembrane Signaling Protein, Inhibits Oligodendrocyte Differentiation and Myelination through Intercellular Self-interactions

(2012) Scott Jepson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Ablation of Oligodendrocytes Induces Axonal Pathology Independent of Overt Demyelination

(2012) L.-J. Oluich et al.   JOURNAL OF NEUROSCIENCE

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

(2012) Peter Connick et al.   LANCET NEUROLOGY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

(2012) Seonok Lee et al.   NATURE METHODS

Primary oligodendrocyte death does not elicit anti-CNS immunity

(2012) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Segmentation of magnetization transfer ratio lesions for longitudinal analysis of demyelination and remyelination in multiple sclerosis

(2012) Robert A. Brown et al.   NEUROIMAGE

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

(2011) Natalia Manrique-Hoyos et al.   ANNALS OF NEUROLOGY

Olesoxime accelerates myelination and promotes repair in models of demyelination

(2011) Karine Magalon et al.   ANNALS OF NEUROLOGY

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

(2011) Gabrièle Piaton et al.   BRAIN

Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation

(2011) Federica De Angelis et al.   Developmental Neurobiology

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

(2011) Y. A. Syed et al.   JOURNAL OF NEUROSCIENCE

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

(2011) H. B. F. Pohl et al.   JOURNAL OF NEUROSCIENCE

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords

(2011) Eric C. Klawiter et al.   NEUROIMAGE

Magnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice

(2011) P. Chandran et al.   NEUROSCIENCE

Targeted Ablation of Oligodendrocytes Triggers Axonal Damage

(2011) Aniket Ghosh et al.   PLoS One

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

(2011) S. Y. C. Chong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-11C]-2-(4′-methylaminophenyl)- 6-hydroxybenzothiazole

(2010) Bruno Stankoff et al.   ANNALS OF NEUROLOGY

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

(2010) Maria Traka et al.   BRAIN

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Oestrogen receptor β ligand: a novel treatment to enhance endogenous functional remyelination

(2010) Daniel K. Crawford et al.   BRAIN

Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination

(2010) Sabah Mozafari et al.   BRAIN RESEARCH

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

(2010) Fanie Barnabé-Heider et al.   Cell Stem Cell

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Role of Chondroitin Sulfate Proteoglycans in Axonal Conduction in Mammalian Spinal Cord

(2010) A. S. Hunanyan et al.   JOURNAL OF NEUROSCIENCE

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination

(2010) Beata Jablonska et al.   NATURE NEUROSCIENCE

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Cell cycle dynamics of NG2 cells in the postnatal and ageing brain

(2010) Konstantina Psachoulia et al.   Neuron Glia Biology

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects

(2010) Clare E. Buckley et al.   NEUROPHARMACOLOGY

Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV

(2010) P.N. Koutsoudaki et al.   NEUROSCIENCE

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

(2009) Sha Mi et al.   ANNALS OF NEUROLOGY

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

(2009) Alexandra S. Baer et al.   BRAIN

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Axonal Protective Effects of the Myelin-Associated Glycoprotein

(2009) T. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Axial Diffusivity Is the Primary Correlate of Axonal Injury in the Experimental Autoimmune Encephalomyelitis Spinal Cord: A Quantitative Pixelwise Analysis

(2009) M. D. Budde et al.   JOURNAL OF NEUROSCIENCE

Pregnancy, prolactin and white matter regeneration

(2009) Christopher Gregg   JOURNAL OF THE NEUROLOGICAL SCIENCES

Accumulation of cortical lesions in MS: relation with cognitive impairment

(2009) SD Roosendaal et al.   Multiple Sclerosis Journal

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate

(2009) V. Skihar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive remyelination of the CNS leads to functional recovery

(2009) I. D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

(2009) Yueting Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon-Glial Signaling and the Glial Support of Axon Function

(2008) Klaus-Armin Nave et al.   Annual Review of Neuroscience

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination

(2008) P.G. Franco et al.   EXPERIMENTAL NEUROLOGY

Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord

(2008) C P Gilmore et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

(2008) L.-A. Harsan et al.   JOURNAL OF NEUROSCIENCE

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

MR Relaxation in Multiple Sclerosis

(2008) A.L. MacKay et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins

(2008) Yasir A. Syed et al.   Neurosurgical Focus

The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation

(2008) S. S. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse

(2008) Y ZHANG et al.   SCHIZOPHRENIA RESEARCH

Picturing Multiple Sclerosis: Conventional and Diffusion Tensor Imaging

(2008) Robert Fox   SEMINARS IN NEUROLOGY

Myelin water imaging of multiple sclerosis at 7 T: Correlations with histopathology

(2007) Cornelia Laule et al.   NEUROIMAGE