Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

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Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

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Altered human oligodendrocyte heterogeneity in multiple sclerosis

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Oxysterols and Apolipoproteins in Multiple Sclerosis: A 5-year Follow-up Study

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Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

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Comprehensive Integration of Single-Cell Data

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Central nervous system regeneration is driven by microglia necroptosis and repopulation

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Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

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Multiple Sclerosis

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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

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Defective cholesterol clearance limits remyelination in the aged central nervous system

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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

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Active liver X receptor signaling in phagocytes in multiple sclerosis lesions

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Remyelination therapies: a new direction and challenge in multiple sclerosis

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Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

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Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

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Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord

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Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

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Active liver X receptor signaling in phagocytes in multiple sclerosis lesions

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Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

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An updated histological classification system for multiple sclerosis lesions

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Dissociated sterol-based liver X receptor agonists as therapeutics for chronic inflammatory diseases

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Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury

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Age-related myelin degradation burdens the clearance function of microglia during aging

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LXR Regulation of Brain Cholesterol: From Development to Disease

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Inefficient clearance of myelin debris by microglia impairs remyelinating processes

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Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

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Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans

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iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

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Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

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Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

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Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

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Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation

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Identification of a microglia phenotype supportive of remyelination

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Central nervous system: cholesterol turnover, brain development and neurodegeneration

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