Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease

Isatin derivatives as DNA minor groove-binding agents: a structural and theoretical study

(2020) Maritza Maldonado-Santiago et al.   STRUCTURAL CHEMISTRY

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

(2020) Helen Shiells et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Amyloid-β Protein agents for the treatment of Alzheimer’s Disease: An update on emerging drugs

(2020) Madia Lozupone et al.   EXPERT OPINION ON EMERGING DRUGS

Targeting tau: Clinical trials and novel therapeutic approaches

(2020) Lawren VandeVrede et al.   NEUROSCIENCE LETTERS

Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization

(2020) Hamad Yadikar et al.   PLoS One

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

(2019) Kai Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease

(2019) Rosa Purgatorio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases

(2019) M. S. Vishnu et al.   ChemMedChem

Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches

(2019) Juan F. González et al.   Expert Opinion on Drug Discovery

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

(2019) Nour M. Moussa‐Pacha et al.   MEDICINAL RESEARCH REVIEWS

Discovery of novel indole-based aroylhydrazones as anticonvulsants: Pharmacophore-based design

(2019) Violina T. Angelova et al.   BIOORGANIC CHEMISTRY

In silico structure‐based design of GABA B receptor agonists using a combination of docking and QSAR

(2019) Zuleyma Martínez‐Campos et al.   Chemical Biology & Drug Design

A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

(2019) Bolognino et al.   MOLECULES

Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications

(2018) Alexei Medvedev et al.   BIOFACTORS

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

(2018) Rosa Purgatorio et al.   MOLECULES

Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases

(2018) Alba Espargaró et al.   ACS Chemical Neuroscience

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors

(2018) Leonardo Pisani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT

(2018) Josué Rodríguez-Lozada et al.   MOLECULES

Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity

(2017) Leonardo Pisani et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

(2016) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Pharmacological Evaluation and Molecular Docking Studies of Substituted Oxadiazolyl-2-Oxoindolinylidene Propane Hydrazide Derivatives

(2016) Deweshri Kerzare et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

(2016) Alba Espargaró et al.   Scientific Reports

8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

(2016) José L. Domínguez et al.   ChemistrySelect

Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation

(2015) Michele Tonelli et al.   ChemMedChem

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

(2015) Roberta Farina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isatin-phenylhydrazone dyes and boron complexes with large Stokes shifts: synthesis and solid-state fluorescence characteristics

(2015) Jie Zheng et al.   TETRAHEDRON

First Selective Dual Inhibitors of Tau Phosphorylation and Beta-Amyloid Aggregation, Two Major Pathogenic Mechanisms in Alzheimer’s Disease

(2014) Marica Mariano et al.   ACS Chemical Neuroscience

Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1–40) aggregation and toxicity

(2014) Marco Catto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Thioflavin-S Staining of Bacterial Inclusion Bodies for the Fast, Simple, and Inexpensive Screening of Amyloid Aggregation Inhibitors

(2014) S. Pouplana et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

(2013) Chengyuan Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase

(2012) Marco Catto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues

(2010) Clarina I. Manley-King et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors

(2010) Francesco Campagna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ConfGen: A Conformational Search Method for Efficient Generation of Bioactive Conformers

(2010) K. Shawn Watts et al.   Journal of Chemical Information and Modeling

Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as β-amyloid aggregation inhibitors

(2009) Marco Catto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel and Mild Route to Phthalocyanines and 3-Iminoisoindolin-1-onesvia N,N-Diethylhydroxylamine-Promoted Conversion of Phthalonitriles and a Dramatic Solvent-Dependence of the Reaction

(2007) Konstantin V. Luzyanin et al.   ADVANCED SYNTHESIS & CATALYSIS