8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

(2016) Federica Prati et al.   ChemMedChem

Implication of coumarins towards central nervous system disorders

(2016) Krystyna Skalicka-Woźniak et al.   PHARMACOLOGICAL RESEARCH

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

(2015) Iveta Najmanova et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors

(2015) Leonardo Pisani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

(2015) Anuradha Thakur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

(2015) Roberta Farina et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease

(2015) Jonathan Brouillette   CURRENT PHARMACEUTICAL DESIGN

Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

(2014) Natalia Guzior et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives

(2014) Masoumeh Alipour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computer-Aided Structure-Based Design of Multitarget Leads for Alzheimer’s Disease

(2014) José L. Domínguez et al.   Journal of Chemical Information and Modeling

Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

(2014) Slavka Hamulakova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer’s disease

(2013) Pravin O. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer’s disease

(2013) Ren-Shi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Successes and Failures for Drugs in Late-Stage Development for Alzheimer’s Disease

(2013) Camryn Berk et al.   DRUGS & AGING

Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors

(2013) Seyyede Faeze Razavi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors

(2013) Leonardo Pisani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Immobilized cholinesterases capillary reactors on-flow screening of selective inhibitors

(2013) Adriana Ferreira Lopes Vilela et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

(2012) Marco Catto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases

(2012) L. Pisani et al.   CURRENT MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

Inhibition of amyloid-β aggregation by coumarin analogs can be manipulated by functionalization of the aromatic center

(2011) Deborah D. Soto-Ortega et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease

(2011) Irene Bolea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity

(2010) Maria Laura Bolognesi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

(2010) Leonardo Pisani et al.   ChemMedChem

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

(2009) Yiping Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible, and Orally Active Monoamine Oxidase B Inhibitor

(2009) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

(2008) Francesco Leonetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ1–40 aggregation in vitro

(2008) Saverio Cellamare et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae

(2007) Mauro Mazzei et al.   BIOORGANIC & MEDICINAL CHEMISTRY