Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization

Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury

(2019) Abdalla Z. Mohamed et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

(2019) Min Qin et al.   Acta Neuropathologica Communications

Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation

(2019) Richard Rubenstein et al.   Frontiers in Neurology

Cyclooxygenase-2 is critical for the propagation of β-amyloid protein and reducing the glycosylation of tau in Alzheimer’s disease

(2019) Pei-Pei Guan et al.   Cellular & Molecular Immunology

Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer’s Disease

(2019) Carol J. Huseby et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

An update on diagnostic and prognostic biomarkers for traumatic brain injury

(2018) Kevin K. Wang et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

(2018) Ratan V. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

(2018) Julia E. Gerson et al.   Molecular Neurodegeneration

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment

(2018) Qing Zhang et al.   Frontiers in Molecular Neuroscience

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

(2018) Taeko Kimura et al.   Frontiers in Neuroscience

Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis

(2018) Yuen-Shan Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species

(2018) Mirta Boban et al.   JOURNAL OF NEUROSCIENCE METHODS

Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia

(2018) Zibo Zhao et al.   GENES & DEVELOPMENT

Caenorhabditis elegans models of tauopathy

(2017) Ghulam Jeelani Pir et al.   FASEB JOURNAL

Tauopathies: Mechanisms and Therapeutic Strategies

(2017) Chen-Chen Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

The Biological Basis of Chronic Traumatic Encephalopathy following Blast Injury: A Literature Review

(2017) Matt Aldag et al.   JOURNAL OF NEUROTRAUMA

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease

(2017) Veena Theendakara et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A validated antibody panel for the characterization of tau post-translational modifications

(2017) Ebru Ercan et al.   Molecular Neurodegeneration

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

The Current Status of Research on Chronic Traumatic Encephalopathy

(2017) Kenneth Perrine et al.   World Neurosurgery

In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line

(2017) Naruhiko Sahara et al.   Frontiers in Neurology

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

Inhibition of PHF-like Tau Hyperphosphorylation in SH-SY5Y Cells and Rat Brain Slices by K252a

(2017) Gabriele Hübinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Incorporation of Tau Isoforms in Alzheimer's Disease

(2017) Marisol Espinoza et al.   JOURNAL OF ALZHEIMERS DISEASE

LiCl Attenuates Thapsigargin-Induced Tau Hyperphosphorylation by Inhibiting GSK-3β In Vivo and In Vitro

(2017) Zheng-Qi Fu et al.   JOURNAL OF ALZHEIMERS DISEASE

miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease

(2016) Wei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation

(2016) Núbia Broetto et al.   BRAIN RESEARCH BULLETIN

Original Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neurons

(2016) Liang Zhao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy

(2016) Francesco Panza et al.   Immunotherapy

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

(2016) Andrea F. N. Rosenberger et al.   Journal of Neuroinflammation

Detecting tau in serum of transgenic animal models after tau immunotherapy treatment

(2016) Cristina d'Abramo et al.   NEUROBIOLOGY OF AGING

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity

(2016) Kanae Ando et al.   PLoS Genetics

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

(2016) Siân Baker et al.   Acta Neuropathologica Communications

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

(2014) Flavia D. Toledo et al.   ARCHIVES OF TOXICOLOGY

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Linking Traumatic Brain Injury to Chronic Traumatic Encephalopathy: Identification of Potential Mechanisms Leading to Neurofibrillary Tangle Development

(2014) Brandon Peter Lucke-Wold et al.   JOURNAL OF NEUROTRAUMA

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

(2014) Firas H. Kobeissy et al.   MOLECULAR NEUROBIOLOGY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

(2014) Franck R. Petry et al.   PLoS One

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP+and rotenone

(2013) Varduhi H. Knaryan et al.   JOURNAL OF NEUROCHEMISTRY

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

Okadaic Acid: More than a Diarrheic Toxin

(2013) Vanessa Valdiglesias et al.   Marine Drugs

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

(2013) P.K. Kamat et al.   NEUROSCIENCE

Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus

(2013) Chang Liu et al.   PLoS One

Recent developments of protein kinase inhibitors as potential AD therapeutics

(2013) Volkmar Tell et al.   Frontiers in Cellular Neuroscience

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Extensive p-Tau Pathology and SDS-Stable p-Tau Oligomers in Alzheimer's Cortical Synapses

(2012) Kristen M. Henkins et al.   BRAIN PATHOLOGY

Regulation of tau proteolysis by phosphatases

(2012) Sangmook Lee et al.   BRAIN RESEARCH

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models

(2012) Christopher M. Acker et al.   NEUROBIOLOGY OF AGING

Effects of Ginkgolide A on Okadaic Acid-induced Tau Hyperphosphorylation and the PI3K-Akt Signaling Pathway in N2a Cells

(2012) Yan Chen et al.   PLANTA MEDICA

Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

(2012) Alexis Bretteville et al.   Scientific Reports

ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update

(2011) S. Sarno et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies

(2011) Miguel Medina et al.   Frontiers in Molecular Neuroscience

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

An okadaic acid-induced model of tauopathy and cognitive deficiency

(2010) Zhang Zhang et al.   BRAIN RESEARCH

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients

(2010) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

The Prepared Tau Exon-Specific Antibodies Revealed Distinct Profiles of Tau in CSF of the Patients with Creutzfeldt-Jakob Disease

(2010) Cao Chen et al.   PLoS One

Development of cell death-based method for the selectivity screening of caspase-1 inhibitors

(2009) Puneet Chopra et al.   CYTOTECHNOLOGY

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

(2009) A. C. Ludolph et al.   EUROPEAN JOURNAL OF NEUROLOGY

GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects

(2009) Kellen Voss et al.   Molecular Neurodegeneration

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice

(2008) A. Koumura et al.   NEUROSCIENCE