Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

In vivo amyloid aggregation kinetics tracked by time-lapse confocal microscopy in real-time

(2016) Anna Villar-Piqué et al.   Biotechnology Journal

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

In vivo amyloid aggregation kinetics tracked by time-lapse confocal microscopy in real-time

(2016) Anna Villar-Piqué et al.   Biotechnology Journal

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

(2015) Irene Sola et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology

(2015) Ghanim Ullah et al.   PLoS One

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

(2014) F. Javier Pérez-Areales et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Thioflavin-S Staining of Bacterial Inclusion Bodies for the Fast, Simple, and Inexpensive Screening of Amyloid Aggregation Inhibitors

(2014) S. Pouplana et al.   CURRENT MEDICINAL CHEMISTRY

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

(2014) Ornella Di Pietro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease

(2014) Lars Lannfelt et al.   Alzheimers Research & Therapy

Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyondβ-Amyloid: Insights from Clinical Trials

(2014) Qiutian Jia et al.   Biomed Research International

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques

(2014) Steffen Burgold et al.   Acta Neuropathologica Communications

Apigenin reduces human insulin fibrillation in vitro and protects SK-N-MC cells against insulin amyloids

(2013) Rahim Amini et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A novel assay for high-throughput screening of anti-Alzheimer’s disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation

(2013) XUE-QIN HOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Thioflavin-S staining coupled to flow cytometry. A screening tool to detect in vivo protein aggregation

(2012) Alba Espargaró et al.   Molecular BioSystems

Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity

(2012) Panchika Prangkio et al.   PLoS One

Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events

(2012) Xiaohong Xu et al.   Stem Cell Research

Kinetic characterization of amyloid-beta 1–42 aggregation with a multimethodological approach

(2011) Manuela Bartolini et al.   ANALYTICAL BIOCHEMISTRY

Bacterial Inclusion Bodies of Alzheimer's Disease β-Amyloid Peptides Can Be Employed To Study Native-Like Aggregation Intermediate States

(2011) Muralidhar Dasari et al.   CHEMBIOCHEM

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Real-Time Imaging and Quantification of Amyloid-β Peptide Aggregates by Novel Quantum-Dot Nanoprobes

(2009) Kiyotaka Tokuraku et al.   PLoS One

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Amyloids in bacterial inclusion bodies

(2009) Natalia S. de Groot et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

(2008) Lei Wang et al.   PLOS BIOLOGY