Article
Pharmacology & Pharmacy
Burcu Saygideger Demir, Simay Ince, Mustafa Kemal Yilmaz, Aycan Sezan, Ezgi Derinoz, Tugba Taskin-Tok, Yasemin Saygideger
Summary: This study investigates the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines through in silico analyses and experimental validation. The synthesized Pd(II) complexes with the best DNA-binding potential are further characterized. The antitumor properties of these complexes are demonstrated in vitro in different cancer cells, and the mechanisms of cell death are elucidated.
Article
Medicine, Research & Experimental
Shabeeba M. Ashraf, Susobhan Mahanty, Krishnan Rathinasamy
Summary: Securinine effectively inhibits the proliferation of cervical, breast, and lung cancer cells while inducing minimal toxicity in non-malignant HEK cells. It disrupts microtubule organization in both interphase and mitotic phases, as well as inhibits tubulin assembly. Additionally, securinine induces a mitochondrial-dependent ROS response in cancer cells and leads to apoptosis through a p53-dependent pathway in MCF-7 cells.
Article
Chemistry, Physical
Richa Mishra, Himani Chaurasia, Vishal K. Singh, Farha Naaz, Ramendra K. Singh
Summary: A new series of novel Schiff bases have been synthesized and tested for their antimicrobial and antifungal activities, showing promising potential for future applications. The combination of test compounds with established antibiotics led to significantly enhanced potency, while molecular modeling indicated good interactions within the active site of the target enzyme. ADMET protocol predicted favorable properties for intestinal absorption, oral bioavailability and cell permeation of the test compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Pedro Novais, Patricia M. A. Silva, Joana Moreira, Andreia Palmeira, Isabel Amorim, Madalena Pinto, Honorina Cidade, Hassan Bousbaa
Summary: The study revealed the mechanism of action of diarylpentanoid BP-M345 on cancer cells, inhibiting mitosis through microtubule perturbation and causing cancer cell death, highlighting its potential as an antitumor agent.
Article
Chemistry, Medicinal
G. Prakasha, H. D. Revanasiddappa, B. Jayalakshmi, B. T. B. Prabhakar, Chandan Shivamallu, Prashant M. Viswanath, Raghu Ram Achar, Ekaterina Silina, Victor Stupin, Natalia Manturova, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Sanja J. Armakovic, Stevan Armakovic, Shiva Prasad Kollur
Summary: The emerging interest in coordination chemistry and their biological applications has had a novel impact in chemical biology. In this study, a novel benzimidazole derived imine ligand and its Co(III) and Cu(II) complexes were synthesized. The structural elucidations of the compounds were performed, and computational investigations on their properties were conducted. The compounds showed significant anti-proliferative activity against cancer cell lines, and the effect of one compound on neovascularization was evaluated.
Article
Chemistry, Applied
Ameneh Malekhoseini, Morteza Montazerozohori, Reza Naghiha, Esmaeel Panahi Kokhdan, Payam Hayati, Jonathan M. White
Summary: A new N2O2-tetradentate Schiff base ligand was synthesized and characterized. Novel cadmium coordination compounds were prepared and confirmed. The compounds showed antimicrobial, anti-cancer, and antioxidant activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pruthviraj Limbachiya, Vipul Patel, Gaurang Rami, Jabali Vora
Summary: This study investigates the synthesis and characterization of two chitosan dibenzylideneacetone Schiff bases, using various analytical techniques. The antimicrobial activity of the chitosan derivatives was tested against bacterial and fungal strains, while cytotoxicity tests were conducted on different cell lines. The results demonstrate that CHDBA shows promise as a potential treatment option for breast cancer and lung cancer, as it exhibits significant effectiveness and low cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Abdulrhman A. A. Al-Shamry, Mai M. M. Khalaf, Hany M. Abd El-Lateef, Tarek A. A. Yousef, Gehad G. G. Mohamed, Kariman M. Kamal El-Deen, Mohamed Gouda, Ahmed M. M. Abu-Dief
Summary: A Schiff base ligand was synthesized through the condensation of isatin and aniline, and a series of metal complexes derived from the ligand were characterized. The metal complexes exhibited different geometries and thermal decomposition behaviors. The metal complexes showed stronger antibacterial properties and anticancer activities compared to the ligand alone. A DFT investigation provided information on the electronic features of the ligand and its metal complexes. The drug-likeness and ADME characteristics of the compounds were also calculated.
Article
Oncology
Hadi Adibi, Ehsan Beyhaghi, Sonya Hayati, Leila Hosseinzadeh, Niloufar Amin
Summary: This study reports the targeting effect of halogenated isatin derivatives on cancer cell mitochondria and their antiproliferative mechanism. The most potent compounds 5b and 5r showed strong anticancer activity and induced apoptosis through the intrinsic mitochondrial pathway. These findings suggest that these compounds have anticancer properties through the modulation of oxidative stress-mediated mitochondrial apoptosis and immune response.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Ahmed Al-Amiery, Wan Nor Roslam Wan Isahak, Waleed Khalid Al-Azzawi
Summary: The study focused on investigating the corrosion behavior of mild steel in acidic environments and evaluating the effectiveness of an ecofriendly inhibitor called ODHI derived from Isatin. The researchers utilized various techniques to carry out the experiment and found that the inhibition efficacy of ODHI increased with its concentration. The findings were supported by Density Functional Theory computations and demonstrated the potential of ODHI as an effective inhibitor.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Yi Gou, MeiRong Chen, Shanhe Li, JunGang Deng, Jinlong Li, GuiHua Fang, Feng Yang, GuoJin Huang
Summary: The three fluorescent dithiocarbazate-copper complexes showed significant cytotoxicity against pancreatic cancer cell lines, with complex 3 primarily targeting mitochondria and inducing cell death through mechanisms including ferroptosis. This complex is the first copper complex to demonstrate cellular events consistent with ferroptosis in cancer cells and effectively inhibited the growth of ASPC-1 cells in a mouse xenograft model.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Ekta, Divya Utreja, Kamaljit Singh
Summary: The Schiff base (3) was synthesized and characterized, and its potential application as a sensor for toxic Hg2+ ions was evaluated. The binding stoichiometry and complexation mechanism between (3) and Hg2+ ions were revealed through computational and experimental studies. The practical application of the probe (3) in spiked soil extract samples showed promising results.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mehmet Esref Alkis, Kenan Buldurun, Nevin Turan, Yusuf Alan, Unzile Kelestemur Yilmaz, Asim Mantarci
Summary: In this study, a new Schiff base and its Ni(II) and Pd(II) complexes were synthesized and characterized. The antiproliferative activities of these compounds on liver cancer cells were evaluated, and it was found that the complexes exhibited stronger activity than the ligand. Electroporation was also shown to enhance the cytotoxicity of the complexes. These findings suggest that the Ni(II) and Pd(II) complexes have potential as anti-cancer agents, particularly in electrochemotherapy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Materials Science, Multidisciplinary
Danyang Ma, Jianfeng Zhao, Lin Zhang, Jianfeng Huang, Junxia Liu, Tiegang Ren
Summary: Mg alloys have a promising application prospect as a structural material, but their corrosion resistance is very poor. Therefore, developing environmentally friendly and pollution-free corrosion inhibitors to inhibit the corrosion of Mg alloys and studying their inhibition mechanism is important.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Physical
Shoaib Khan, Hayat Ullah, Rafaqat Hussain, Yousaf Khan, Misbah Ullah Khan, Mehmand Khan, Abdul Sattar, Muhammad Saleem Khan
Summary: Isatin/bis-Schiff bases analogues based on thiocarbohydrazone were synthesized, characterized, and tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. All analogues showed good inhibitory potentials, with analogue 1 being the most effective inhibitor. Structure-activity relationship (SAR) analysis revealed the importance of substitution effects on phenyl rings. Molecular docking studies provided insight into the binding interactions of the most active inhibitors with the active sites of AChE and BuChE.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Zhenfeng Shi, Jie Chen, Aikebaier Wumaner, Ming Li, Chengyuan Liang, Min Li
Summary: The novel lncRNA PCLN16 is significantly correlated with AR signaling during prostate cancer progression, enhancing tumor growth via a positive feedback loop. PCLN16 interacts with HIP1 transcript to reduce degradation, suggesting a potential target for therapeutic intervention.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Chemistry, Medicinal
Lei Tian, Taotao Qiang, Chengyuan Liang, Xiaodong Ren, Minyi Jia, Jiayun Zhang, Jingyi Li, Minge Wan, Xin YuWen, Han Li, Wenqiang Cao, Hong Liu
Summary: The RdRp enzyme, a therapeutic target for RNA virus infections, plays a crucial role in RNA synthesis. Promising RdRp inhibitors currently in studies offer potential for developing more effective anti-RNA virus drugs, which may be used for COVID-19 treatment in the current health emergency.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Dengke Tian, Yuzhi Liu, Chengyuan Liang, Liang Xin, Xiaolin Xie, Dezhu Zhang, Minge Wan, Han Li, Xueqi Fu, Hong Liu, Wenqiang Cao
Summary: The SARS-CoV-2 outbreak since late 2019 has presented a global health challenge, but multiple therapeutic drugs have been developed to combat it. Host-targeted drugs inhibiting TMPRSS2 prevent virus entry into cells, while small molecule therapeutics targeting RNA polymerase and proteases play crucial roles in treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Medicinal
Chengyuan Liang, Guaiping Qiao, Yuzhi Liu, Lei Tian, Nan Hui, Juan Li, Yuling Ma, Han Li, Qianqian Zhao, Wenqiang Cao, Hong Liu, Xiaodong Ren
Summary: All-trans-retinoic acid (ATRA) is effective in preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL) by regulating differentiation-related gene transcription and autophagy through inhibiting mTOR. A total of 68 ATRA analogues show promising antitumour therapeutic potential for further development and research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Qianqian Zhao, Liang Xin, Yuzhi Liu, Chengyuan Liang, Jingyi Li, Yanlin Jian, Han Li, Zhenfeng Shi, Hong Liu, Wenqiang Cao
Summary: The widespread use of antibiotics has led to a serious problem of bacterial resistance, making the study of new drug-resistant bacteria the main focus of antibacterial drug research. Oxazolidinone antibacterial drugs, such as linezolid and tedizolid, have good pharmacokinetic and pharmacodynamic characteristics, unique antibacterial mechanisms, and sensitivity to resistant bacteria.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Chengyuan Liang, Juan Li, Bin Tian, Lei Tian, Yuzhi Liu, Jingyi Li, Liang Xin, Jun Wang, Chao Fu, Zhenfeng Shi, Juan Xia, Yiting Liang, Kun Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, which can progress to non-alcoholic steatohepatitis (NASH). The pathogenesis of NASH is complex, involving multiple factors such as metabolic disorders and inflammation. Research on the succinate-GPR91 signaling pathway provides a new direction for the treatment of NASH.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Plant Sciences
Dan Yang, Jingyi Li, Chengyuan Liang, Lei Tian, Chunyang Shi, Nan Hui, Yuan Liu, Mei Ling, Liang Xin, Minge Wan, Han Li, Qianqian Zhao, Xiaodong Ren, Hong Liu, Wenqiang Cao
Summary: Syringa microphylla Diels has been traditionally used as a folk medicine for treating various diseases. Research has shown that its active compounds have antioxidant, antibacterial, anti-inflammatory, and neuroprotective effects. Molecular pharmacology experiments have indicated that the active ingredients primarily exert their pharmacological effects by reducing oxidative stress damage and regulating inflammatory factors.
Review
Medicine, Research & Experimental
Juan Xia, Nan Hui, Lei Tian, Chengyuan Liang, Jie Zhang, Jifang Liu, Jun Wang, Xiaodong Ren, Xiaolin Xie, Kun Wang
Summary: Vericiguat is the first approved drug for reducing symptoms in chronic HF patients, reducing the occurrence of HF worsening. This article provides comprehensive information about Vericiguat and insights into current HF treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Zhenfeng Shi, Lei Tian, Taotao Qiang, Jingyi Li, Yue Xing, Xiaodong Ren, Chang Liu, Chengyuan Liang
Summary: This article discusses the application of more than 50 approved or clinically trialed cyclin-dependent kinase (CDK) inhibitors in multiple cancers. It covers the design strategies, structure-activity relationships, and efficacy performances of both selective and non-selective CDK inhibitors. The review highlights the safer therapeutic potential of selective CDK inhibitors and the approval of four CDK4/6 inhibitors for breast cancer treatment. The emerging strategies in the field of CDK inhibitors are also briefly summarized.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Juan Xia, Jingyi Li, Lei Tian, Xiaodong Ren, Chang Liu, Chengyuan Liang
Summary: This article systematically reviews the research progress on EZH2 inhibitors and proteolysis targeting chimera (PROTAC)-based EZH2 degradation agents, with a focus on their design strategies, structure-activity relationships (SARs), and safety and clinical manifestations.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chunyang Shi, Yangmin Ma, Lei Tian, Jingyi Li, Guaiping Qiao, Chang Liu, Wenqiang Cao, Chengyuan Liang
Summary: In this study, verbascoside demonstrated excellent antibacterial activity and synergistic effects when combined with cell wall synthesis-inhibiting antibiotics, making it a potential adjuvant to enhance the effectiveness of antibiotics. Mechanistically, verbascoside exhibited antimicrobial activity through various mechanisms and showed potential as a novel antimicrobial additive in the food industry.
Review
Biochemistry & Molecular Biology
Zhenfeng Shi, Jie Zhang, Lei Tian, Liang Xin, Chengyuan Liang, Xiaodong Ren, Min Li
Summary: Due to overuse of antibiotics, bacterial resistance has become a global problem and a major threat to human health. Fortunately, in recent years, new antibiotics with improved efficacy and novel mechanisms have been developed. This manuscript reviews approved antibiotics in the last 20 years, emphasizing their antibacterial properties, mechanisms, structure-activity relationships, and clinical safety. It also discusses current deficiencies, improvement opportunities, and prospects of antibiotics to provide insights for the design and development of safer and more potent antibiotics.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
