QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT

5,6-Dihydropyrimidine-1(2 H )-carbothioamides: Synthesis, in vitro GABA-AT screening, anticonvulsant activity and molecular modelling study

(2018) Meeta Sahu et al.   BIOORGANIC CHEMISTRY

Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions

(2018) Richard B. Silverman   CHEMICAL REVIEWS

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

(2018) Jose I. Juncosa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling

(2018) Erika Tovar-Gudiño et al.   MOLECULES

Test for l -glutamate inhibition of growth of Alternaria alternata by inducing resistance in tomato fruit

(2017) Jiali Yang et al.   FOOD CHEMISTRY

Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase

(2017) Usman Abdulfatai et al.   Journal of Advanced Research

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

(2016) David S. Hersh et al.   CURRENT PHARMACEUTICAL DESIGN

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

(2015) Hyunbeom Lee et al.   ACS Chemical Biology

Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids

(2015) Tobias Steffan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase

(2015) Andrea Pinto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators

(2015) Katie M. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Mechanism of Tetrahydrothiophene-Based γ-Aminobutyric Acid Aminotransferase Inactivators

(2015) Hoang V. Le et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

QSAR study of the DPPH· radical scavenging activity of coumarin derivatives and xanthine oxidase inhibition by molecular docking

(2014) Rodrigo S. Razo-Hernández et al.   CENTRAL EUROPEAN JOURNAL OF CHEMISTRY

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

GABAB-Agonistic Activity of Certain Baclofen Homologues

(2013) Mohamed Attia et al.   MOLECULES

Pregabalin for the Treatment of Generalized Anxiety Disorder

(2012) Terri M Wensel et al.   ANNALS OF PHARMACOTHERAPY

Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase

(2012) Dustin D. Hawker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A systematic review on the role of anticonvulsants in the treatment of acute bipolar depression

(2012) María Reinares et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

(2012) Riccardo Zanaletti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a novel potent GABAB receptor agonist

(2011) Feng Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pregabalin is a potent and selective ligand for α2δ-1 and α2δ-2 calcium channel subunits

(2011) Zheng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A QSAR study of radical scavenging antioxidant activity of a series of flavonoids using DFT based quantum chemical descriptors – the importance of group frontier electron density

(2011) Ananda Sarkar et al.   JOURNAL OF MOLECULAR MODELING

Overview of glutamatergic neurotransmission in the nervous system

(2011) Mark J. Niciu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Data collection and advanced statistical analysis in phytotoxic activity of aerial parts exudates of Salvia spp

(2011) M. Giacomini et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

QSAR and docking-based computational chemistry approach to novel GABA-AT inhibitors: kNN-MFA-based 3DQSAR model for phenyl-substituted analogs of β-phenylethylidene hydrazine

(2010) S. K. Bansal et al.   MEDICINAL CHEMISTRY RESEARCH

Novel GABA-AT inhibitors: QSAR and docking based virtual screening of phenyl substituted β-phenyl ethylidene hydrazine analogues

(2010) S. K. Bansal et al.   MEDICINAL CHEMISTRY RESEARCH

Docking and QSAR studies of β-phenylethylidenehydrazine derivatives as a Gamma-aminobutyric acid aminotransferase inhibitor

(2010) Asghar Davood et al.   MEDICINAL CHEMISTRY RESEARCH

From Basic Science to Blockbuster Drug: The Discovery of Lyrica

(2008) Richard B. Silverman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: Design, synthesis, and neuropharmacological evaluation

(2008) Atef A. Abdel-Hafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hormesis and medicine

(2008) Edward J. Calabrese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Modulation of the Epileptic Seizure Threshold: Implications of Biphasic Dose Responses

(2008) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase

(2007) Michael D. Clift et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS