BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

Multidisciplinary approaches for targeting the secretase protein family as a therapeutic route for Alzheimer's disease

(2019) Nalini Schaduangrat et al.   MEDICINAL RESEARCH REVIEWS

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau

(2019) J. Wesson Ashford   JOURNAL OF ALZHEIMERS DISEASE

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease?

(2019) I. Lauritzen et al.   Current Alzheimer Research

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy

(2018) Andrés Crane et al.   Alzheimers & Dementia

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB 1 and CB 2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

(2018) Gemma Navarro et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer’s Disease

(2018) Patricia del Cerro et al.   CNS DRUGS

Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review

(2018) Angela Rampa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders

(2018) Ghulam Hussain et al.   International Journal of Biological Sciences

Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer’s Disease-Like Pathology

(2018) Anne-Caroline Schmöle et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Advances in Drug Development

(2018) Morgane Piton et al.   JOURNAL OF ALZHEIMERS DISEASE

Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons’ Brains Lacking Neuritic Amyloid Plaques

(2018) Erin L. Abner et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-BACE1 and Antimicrobial Activities of Steroidal Compounds Isolated from Marine Urechis unicinctus

(2018) Yong-Zhe Zhu et al.   Marine Drugs

BACE failures lower AD expectations, again

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Microglia-targeted candidates push the Alzheimer drug envelope

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3xTgAD and 2xTgAD mice

(2018) Alexandre Bourgeois et al.   NEUROBIOLOGY OF AGING

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid toxicity in Alzheimer’s disease

(2018) Allison B. Reiss et al.   REVIEWS IN THE NEUROSCIENCES

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery

(2018) Xue-Yang Jiang et al.   ACS Medicinal Chemistry Letters

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

(2018) Karima Schwab et al.   Frontiers in Molecular Neuroscience

Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease

(2018) Isabelle L. Sumner et al.   Frontiers in Neuroscience

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Immunotherapy for neurodegenerative diseases: the Alzheimer's disease paradigm

(2018) Laia Montoliu-Gaya et al.   Current Opinion in Chemical Engineering

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

(2018) Judite R. M. Coimbra et al.   Frontiers in Chemistry

Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

(2018) Bernd Bohrmann et al.   JOURNAL OF ALZHEIMERS DISEASE

CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

The Potential Therapeutic Effects of THC on Alzheimer's Disease

(2018) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway

(2018) Rasha M. Hussein et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Prospecting and Structural Insight into the Binding of Novel Plant-Derived Molecules of Leea indica as Inhibitors of BACE1

(2018) S.M. Zahid Hosen et al.   CURRENT PHARMACEUTICAL DESIGN

A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease

(2018) Justyna A Dobrowolska Zakaria et al.   EMBO Molecular Medicine

Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease

(2018) Xiaobei Pan et al.   NEUROSCIENCE

Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease

(2017) Hamadeh Tarazi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings

(2017) J. Lötsch et al.   EUROPEAN JOURNAL OF PAIN

Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Charbel E-H. Moussa   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

(2017) John Hardy   FEBS Journal

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease

(2017) Federica Prati et al.   JOURNAL OF MEDICINAL CHEMISTRY

A PM7 dynamic residue-ligand interactions energy landscape of the BACE1 inhibitory pathway by hydroxyethylamine compounds. Part I: The flap closure process

(2017) Carlos Gueto-Tettay et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Antibacterial Compounds from Marine Bacteria, 2010–2015

(2017) Claudia Schinke et al.   JOURNAL OF NATURAL PRODUCTS

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

(2017) Sergey O. Bachurin et al.   MEDICINAL RESEARCH REVIEWS

BACE inhibitor bust in Alzheimer trial

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii

(2017) Zhenxing Zou et al.   PHYTOCHEMISTRY

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase III randomized trial of gantenerumab in prodromal Alzheimer’s disease

(2017) Susanne Ostrowitzki et al.   Alzheimers Research & Therapy

Role of BACE1 in Alzheimer’s synaptic function

(2017) Brati Das et al.   Translational Neurodegeneration

Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

(2017) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

(2016) Feilin Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies

(2016) Masuo Ohno   BRAIN RESEARCH BULLETIN

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations

(2016) Maricarmen Hernández-Rodríguez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Computational insights into the protonation states of catalytic dyad in BACE1–acyl guanidine based inhibitor complex

(2016) Abdulkadir Kocak et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Sex differences in metabolic aging of the brain: insights into female susceptibility to Alzheimer's disease

(2016) Liqin Zhao et al.   NEUROBIOLOGY OF AGING

Endogenous APP accumulates in synapses after BACE1 inhibition

(2016) Saket Milind Nigam et al.   NEUROSCIENCE RESEARCH

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Discovery of polymethoxyflavones from black ginger ( Kaempferia parviflora ) as potential β-secretase (BACE1) inhibitors

(2016) Kumju Youn et al.   Journal of Functional Foods

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

(2016) Saoussen Ben Halima et al.   Cell Reports

Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs

(2016) Riqiang Yan   Translational Neurodegeneration

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

(2016) Mark Ultsch et al.   Scientific Reports

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer’s Disease

(2015) Federica Prati et al.   ACS Chemical Neuroscience

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

(2015) Kenneth M. Boy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

(2015) Prasanna Sivaprakasam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression

(2015) Holly C. Hunsberger et al.   JOURNAL OF NEUROCHEMISTRY

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages

(2015) L. Devi et al.   NEUROSCIENCE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

Anti-allergenic activity of polymethoxyflavones from Kaempferia parviflora

(2015) Shoko Kobayashi et al.   Journal of Functional Foods

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

(2015) Yuan Cheng et al.   ACS Medicinal Chemistry Letters

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method

(2014) Hoda Mirsafian et al.   TheScientificWorldJOURNAL

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

(2013) Heinrich Rueeger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Safety and Pharmacology of a Single Intravenous Dose of Ponezumab in Subjects With Mild-to-Moderate Alzheimer Disease

(2013) Jaren W. Landen et al.   CLINICAL NEUROPHARMACOLOGY

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

(2013) Hans Hilpert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

(2013) Jing Yuan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Soluble oligomers and fibrillar species of amyloid β-peptide differentially affect cognitive functions and hippocampal inflammatory response

(2012) Yan He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

(2012) Jared N. Cumming et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BACE1 Dependent Neuregulin Processing: Review

(2012) Daniel Fleck et al.   Current Alzheimer Research

Insulin: An Emerging Treatment for Alzheimer’s Disease Dementia?

(2012) Jill K. Morris et al.   Current Neurology and Neuroscience Reports

Modulatory effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes

(2012) Catheleeya Mekjaruskul et al.   JOURNAL OF ETHNOPHARMACOLOGY

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A 

(2012) O. Adolfsson et al.   JOURNAL OF NEUROSCIENCE

Ab initio modeling of a potent isophthalamide-based BACE-1 inhibitor: amino acid decomposition analysis

(2012) Nima Razzaghi-Asl et al.   MEDICINAL CHEMISTRY RESEARCH

Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship

(2012) Amandine Grimm et al.   MOLECULAR NEUROBIOLOGY

Identification of BACE2 as an avid ß-amyloid-degrading protease

(2012) Samer O Abdul-Hay et al.   Molecular Neurodegeneration

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

(2012) Maite Solas et al.   NEUROBIOLOGY OF AGING

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway

(2012) Gohar Fakhfouri et al.   NEUROPHARMACOLOGY

Tau as a therapeutic target in neurodegenerative disease

(2012) Diana S. Himmelstein et al.   PHARMACOLOGY & THERAPEUTICS

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

(2011) Yechun Xu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors

(2011) S. Schenone et al.   CURRENT MEDICINAL CHEMISTRY

Quantum mechanics study of the hydroxyethylamines–BACE-1 active site interaction energies

(2011) Carlos Gueto-Tettay et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Design, Synthesis, and Qualitative Structure–Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer’s Drug Leads

(2011) Taleb H. Al-Tel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Sink Hypothesis and Therapeutic Strategies for Attenuating Aβ Levels

(2011) Yan Zhang et al.   NEUROSCIENTIST

Creation and manipulation of common functional groups en route to a skeletally diverse chemical library

(2011) J. Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

CB2: a cannabinoid receptor with an identity crisis

(2010) Brady K Atwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Methods to Explore Marine Resources for Alzheimers Therapeutics

(2010) P. Williams et al.   Current Alzheimer Research

β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

(2010) Wan-Pin Chang et al.   FASEB JOURNAL

Design and Synthesis of Potent and Selective BACE-1 Inhibitors

(2010) Catarina Björklund et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors

(2009) Taleb H. Al-Tel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

(2008) Paul Beswick et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid   Protein Production

(2008) H. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

β-Secretase as a therapeutic target for Alzheimer’s disease

(2008) Arun K. Ghosh et al.   Neurotherapeutics

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

(2007) Arun K. Ghosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS