Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches

New Evolutions in the BACE1 Inhibitor Field from 2014 to 2018

(2019) Chien-Chi Hsiao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

(2019) Yann Fichou et al.   Acta Neuropathologica Communications

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

(2019) Stefano Alcaro et al.   Frontiers in Chemistry

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease

(2019) Tao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage

(2018) K. Rajasekhar et al.   ACS Chemical Neuroscience

Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach

(2018) María Jesús Oset-Gasque et al.   ACS Chemical Neuroscience

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease

(2018) Iryna Voytyuk et al.   BIOLOGICAL PSYCHIATRY

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Multi-Target-Directed Ligands Affecting Serotonergic Neurotransmission for Alzheimer’s Disease Therapy: Advances in Chemical and Biological Research

(2018) Agnieszka Jankowska et al.   CURRENT MEDICINAL CHEMISTRY

Flavonoids in the treatment of Alzheimer’s and other neurodegenerative diseases

(2018) Cristina Airoldi et al.   CURRENT MEDICINAL CHEMISTRY

A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease

(2018) Leili Jalili-Baleh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

(2018) A. Prasanth Saraswati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent developments with tau-based drug discovery

(2018) Khalid Iqbal et al.   Expert Opinion on Drug Discovery

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metal Ion Effects on Aβ and Tau Aggregation

(2018) Anne Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease

(2018) Alireza Atri et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid-β and Tau in Alzheimer’s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

(2018) Rebecca M. Nisbet et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines

(2018) Dénes Zádori et al.   JOURNAL OF ALZHEIMERS DISEASE

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

(2018) et al.   MOLECULES

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Alzheimer Disease

(2018) Maileen Gloriane Ulep et al.   JNP-Journal for Nurse Practitioners

Alzheimer’s Disease (AD) therapeutics - 1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality

(2018) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Potential Enzymatic Targets in Alzheimer’s: A Comprehensive Review

(2018) Jahangir Alam et al.   CURRENT DRUG TARGETS

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease

(2018) Ulf Neumann et al.   EMBO Molecular Medicine

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

(2018) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

(2018) Luca Piemontese et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

(2018) Annachiara Gandini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial therapeutic interventions in Alzheimer’s disease

(2018) Vo Van Giau et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer’s Disease

(2018) Huan Wang et al.   ACS Chemical Neuroscience

Beyond the Amyloid Hypothesis of Alzheimer’s Disease: Tau Pathology Takes Center Stage

(2018)   ACS Chemical Neuroscience

Chromones: privileged scaffolds for the production of multi-target-directed-ligand agents for the treatment of Alzheimer’s disease

(2018) Carlos F. M. Silva et al.   Expert Opinion on Drug Discovery

BACE inhibitors in clinical development for the treatment of Alzheimer’s disease

(2018) Francesco Panza et al.   Expert Review of Neurotherapeutics

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

(2018) M. Tzioras et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease

(2018) Abha Sharma et al.   Frontiers in Pharmacology

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

(2017) Bilqees Sameem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An update on the advancements in the treatment of agitation in Alzheimer’s disease

(2017) Anton P. Porsteinsson et al.   EXPERT OPINION ON PHARMACOTHERAPY

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants

(2017) Maarten Timmers et al.   JOURNAL OF ALZHEIMERS DISEASE

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

(2017) Valle Palomo et al.   JOURNAL OF MEDICINAL CHEMISTRY

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease

(2017) Federica Prati et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective Effects of Caffeic Acid and the Alzheimer's Brain: An Update

(2017) Solomon Habtemariam   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration

(2017) Patrícia Molz et al.   Frontiers in Pharmacology

Serotonin 5-HT6 Receptor Antagonists in Alzheimer’s Disease: Therapeutic Rationale and Current Development Status

(2016) Hilda Ferrero et al.   CNS DRUGS

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AVP-786 for the treatment of agitation in dementia of the Alzheimer’s type

(2016) Ricardo P. Garay et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium

(2016) Davide Seripa et al.   Expert Review of Neurotherapeutics

Brain biometals and Alzheimer's disease – boon or bane?

(2016) Atish Prakash et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide

(2016) Rachelle Balez et al.   Oxidative Medicine and Cellular Longevity

A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease

(2016) William James Deardorff et al.   Drug Design Development and Therapy

Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease

(2016) Simona Magi et al.   Biomed Research International

Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium

(2016) Davide Seripa et al.   Expert Review of Neurotherapeutics

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

(2016) José Marco-Contelles et al.   Frontiers in Neuroscience

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

(2016) Mercedes Unzeta et al.   Frontiers in Neuroscience

Privileged scaffolds in lead generation

(2015) Hongyu Zhao et al.   Expert Opinion on Drug Discovery

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure

(2015) Zoran Rankovic   JOURNAL OF MEDICINAL CHEMISTRY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Shinji Matsunaga et al.   PLoS One

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coumarin hybrids as novel therapeutic agents

(2014) Sonali Sandhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

(2014) Angel Agis-Torres et al.   Current Neuropharmacology

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

(2014) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer’s disease

(2013) Pravin O. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Focusing on New Monoamine Oxidase Inhibitors: Differently Substituted Coumarins As An Interesting Scaffold

(2013) Maria Joao Matos et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Safety and Efficacy of Methylphenidate for Apathy in Alzheimer’s Disease

(2013) Paul B. Rosenberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles

(2012) Juan F. González et al.   CHEMICAL SOCIETY REVIEWS

Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma

(2012) Tara C. Gangadhar et al.   INVESTIGATIONAL NEW DRUGS

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

Misfolded proteins in Alzheimer's disease and type II diabetes

(2011) Alaina S. DeToma et al.   CHEMICAL SOCIETY REVIEWS

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Designing Multiple Ligands – Medicinal Chemistry Strategies and Challenges

(2009) Richard Morphy et al.   CURRENT PHARMACEUTICAL DESIGN

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease☆

(2008) Annette Maczurek et al.   ADVANCED DRUG DELIVERY REVIEWS

Ferulic acid and its therapeutic potential as a hormetin for age-related diseases

(2008) Eugenio Barone et al.   BIOGERONTOLOGY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional neuroprotective derivatives of rasagiline as anti-alzheimer’s disease drugs

(2008) Orly Weinreb et al.   Neurotherapeutics