An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo

(2020) Amy R. Nelson et al.   Frontiers in Aging Neuroscience

In vitro modeling of the neurovascular unit: advances in the field

(2020) Aditya Bhalerao et al.   Fluids and Barriers of the CNS

Assembling human brain organoids

(2019) Sergiu P. Paşca   SCIENCE

Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer’s Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma

(2019) Emily Button et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease

(2019) Adam M. Staffaroni et al.   JAMA Neurology

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Plasma and CSF neurofilament light

(2019) Michelle M. Mielke et al.   NEUROLOGY

Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues

(2019) Liqing Song et al.   Scientific Reports

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead

(2019) Joel Simrén et al.   CURRENT OPINION IN NEUROBIOLOGY

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array

(2018) Sehoon Jeong et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective

(2018) Geoffrey Potjewyd et al.   TRENDS IN BIOTECHNOLOGY

Cerebral amyloid angiopathy: diagnosis and potential therapies

(2018) Stewart A. Weber et al.   Expert Review of Neurotherapeutics

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

(2018) Philip Seibler et al.   BRAIN

Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease

(2018) Jack C. de la Torre   JOURNAL OF ALZHEIMERS DISEASE

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

(2017) Jérôme Robert et al.   Molecular Neurodegeneration

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet

(2017) P.E. Bunney et al.   PHYSIOLOGY & BEHAVIOR

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

(2017) Jerome Robert et al.   eLife

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

(2016) Li Zhong et al.   Molecular Neurodegeneration

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

(2016) Jianjia Fan et al.   PLoS One

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Cerebral Collaterals and Collateral Therapeutics for Acute Ischemic Stroke

(2015) Ian R. Winship   MICROCIRCULATION

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

A Three-Dimensional Engineered Artery Model for In Vitro Atherosclerosis Research

(2013) Jérôme Robert et al.   PLoS One

Human Umbilical Vein Endothelial Cells Protect Against Hypoxic-Ischemic Damage in Neonatal Brain via Stromal Cell-derived Factor 1/C-X-C Chemokine Receptor Type 4

(2013) Chia-Ching Wu et al.   STROKE

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

Plasma tau levels in Alzheimer's disease

(2013) Henrik Zetterberg et al.   Alzheimers Research & Therapy

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure

(2012) Stefania Mondello et al.   BMC Neurology

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete theO-Glycosylated Form

(2010) Shinobu Kitazume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE