Article
Biochemistry & Molecular Biology
Thoa Kim Truong Huynh, Trinh Thi Thu Mai, Man Anh Huynh, Hideki Yoshida, Masamitsu Yamaguchi, Thao Thi Phuong Dang
Summary: This study demonstrates the impact of UCH-L1 deficiency on motor neuron health using a Drosophila model, highlighting the crucial role of UCH-L1 in neuronal health.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Emergency Medicine
Asim Kalkan, Ahmet Demirel, Seref Emre Atis, Edip Burak Karaaslan, Mehmet Esat Ferhatlar, Mucahit Senturk
Summary: This study aimed to evaluate the utility of serum NRGN level in the differentiation of epilepsy and PNES patients. The results showed that the serum NRGN level was significantly higher in epilepsy patients compared to the control group, suggesting its potential as a biomarker for distinguishing epileptic seizure and PNES.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Rui Chen, Li-Rong Lin, Yao Xiao, Wu-Jian Ke, Tian-Ci Yang
Summary: CSF UCH-L1, GFAP, and NF-L can serve as novel markers for the diagnosis of neurosyphilis. They exhibit high sensitivity and specificity for NS diagnosis with specific cut-off points. Furthermore, they show weak or moderate correlations with CSF RPR, WBC, and protein, and can be used independently of these markers.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Clinical Neurology
Haogang Sun, Xinxin Li, Qi Guo, Songyan Liu
Summary: Prolonged and repeated epileptic seizures can lead to various changes in the brain, ultimately resulting in neuronal death. Oxidative stress plays a critical role in neuronal death induced by epileptic seizures. The research aims to elucidate the molecular mechanism of neuronal death and explore the moderating effect of oxidative stress on neuronal death.
NEUROLOGICAL SCIENCES
(2022)
Review
Cell Biology
Shinichi Kinoshita, Ryuta Koyama
Summary: Microglia in the epileptic brain exhibit different activation phenotypes, but their exact roles remain unclear.
NEURAL REGENERATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Julia Reichelt, Wiebke Sachs, Sarah Froembling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krueger, Catherine Meyer-Schwesinger
Summary: In membranous nephropathy, autoantibodies target podocytes of the kidney filter, resulting in injury. The authors found that the disturbances in protein stability and proteinuria are related to abnormal interactions between non-functional UCH-L1 enzyme and the proteasome, reducing its capacity. The mechanistic significance of the ubiquitin proteasome system (UPS) in a kidney autoimmune environment is not well understood.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Zhihan Wang, Dabin Ren, Ping Zheng
Summary: Epilepsy is a severe neurological disorder characterized by recurrent seizures. While most patients can be cured with anti-epileptic drugs, a significant number of patients are resistant to treatment. Studies have shown that the Rho/Rho-associated kinase (ROCK) pathway may be involved in the pathogenesis of epilepsy. Inhibitors targeting this pathway have shown potential in the treatment of epilepsy and related neurological diseases.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Anatoly Buchin, Rebecca de Frates, Anirban Nandi, Rusty Mann, Peter Chong, Lindsay Ng, Jeremy Miller, Rebecca Hodge, Brian Kalmbach, Soumita Bose, Ueli Rutishauser, Stephen McConoughey, Ed Lein, Jim Berg, Staci Sorensen, Ryder Gwinn, Christof Koch, Jonathan Ting, Costas A. Anastasslou
Summary: Temporal lobe epilepsy, a common neurological disorder, often does not respond to pharmacological treatment. This study found that hippocampal granule cells undergo changes, becoming more excitable and increasing in size, as the disease progresses. The changes in cellular properties are linked to specific conductances. A network model demonstrated that these changes lead to an increase in circuit excitability, and reverting them can restore a less excitable early-disease state.
Article
Pharmacology & Pharmacy
Yang Hu, Yuanyuan Yao, Honggang Qi, Jiurong Yang, Canyu Zhang, Aifeng Zhang, Xiufang Liu, Chenchen Zhang, Guangming Gan, Xinjian Zhu
Summary: This study reveals the mechanism by which microglia regulate epileptic neuronal hyperexcitability through CD39-dependentsignaling, highlighting the importance of the interaction between microglia and neurons in epilepsy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Frederick K. Korley, Sonia Jain, Xiaoying Sun, Ava M. Puccio, John K. Yue, Raquel C. Gardner, Kevin K. W. Wang, David O. Okonkwo, Esther L. Yuh, Pratik Mukherjee, Lindsay D. Nelson, Sabrina R. Taylor, Amy J. Markowitz, Ramon Diaz-Arrastia, Geoffrey T. Manley
Summary: The prognostic value of GFAP and UCH-L1 as predictors of functional outcome after traumatic brain injury is significant. GFAP and UCH-L1 have good to excellent prognostic value for predicting death and unfavorable outcome, but not for predicting incomplete recovery at 6 months. These biomarkers contribute the most prognostic information for participants with a GCS score of 3-12.
Article
Mathematics
Zhihui Wang, Yanying Yang, Lixia Duan
Summary: Using a thalamocortical neural field model, this study explored the dynamic mechanism of system transition in epilepsy. The results showed that excitatory interneurons induce transitions from 1-spike and wave discharges to 2-spike and wave discharges, inhibitory interneurons induce transitions from saturated state to tonic oscillation state, and the thalamic relay nucleus induces transitions from clonic oscillation state to saturated state.
ELECTRONIC RESEARCH ARCHIVE
(2023)
Article
Medical Laboratory Technology
Charlotte Oris, Jean-Baptiste Bouillon-Minois, Samy Kahouadji, Bruno Pereira, Gabriel Dhaiby, Valentin Bailly Defrance, Julie Durif, Jeannot Schmidt, Fares Moustafa, Damien Bouvier, Vincent Sapin
Summary: Measuring plasma GFAP and UCH-L1 levels is useful in targeting and optimizing the reduction of CT scans in mTBI patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Pharmacology & Pharmacy
M. ZHANG, M. -Y. CHEN, S. -L. WANG, X. -M. DING, R. YANG, J. LI, G. -H. JIANG
Summary: This study aimed to investigate the relationship between serum ubiquitin c-terminal hydrolase (Uch-L1) and cognition and brain energy metabolism, and whether it can be used as an early blood marker for Alzheimer's disease. The results showed a significant correlation between serum Uch-L1 concentration and cognitive ability and brain energy metabolism, suggesting its potential as a blood marker for extensive dementia screening in the future.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Oncology
Richard S. P. Huang, Karthikeyan Murugesan, Meagan Montesion, Dean C. Pavlick, Douglas A. Mata, Matthew C. Hiemenz, Brennan Decker, Garrett Frampton, Lee A. Albacker, Jeffrey S. Ross
Summary: The study analyzed a large cohort of solid tumor cases to investigate CD274 copy-number changes and their correlation with PD-L1 protein expression. The prevalence of CD274 copy-number changes varied across different tumor types and was found to be significantly associated with PD-L1 positivity in certain tumor types, indicating its potential as a biomarker for immune checkpoint inhibitor therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Engineering, Biomedical
Wenjuan Xiong, Ewan S. Nurse, Elisabeth Lambert, Mark J. Cook, Tatiana Kameneva
Summary: This study investigates the use of machine learning techniques for classification of psychogenic non-epileptic seizures (PNES) and epileptic seizures (ES) based on electroencephalography (EEG) and electrocardiography (ECG) data. The highest classification accuracy achieved was 87.83%, using the 15-0 minute preictal period of EEG and ECG data. Combining ECG data with EEG data improved the classification accuracy from 86.37% to 87.83%.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carmela Visalli, Sergio Lucio Vinci, Stefania Mondello, Firas Kobeissy, Ignazio Salamone, Alessandra Coglitore, Renato Trimarchi, Agostino Tessitore, Pietro Impellizzeri, Enricomaria Mormina
Summary: This retrospective study compared the applications of power Doppler and MicroV in evaluating pediatric patients with early-stage scrotal pain. MicroV imaging technique showed higher reliability in vascularization detection, especially in diagnosing testicular torsion and epididymitis.
JAPANESE JOURNAL OF RADIOLOGY
(2022)
Article
Clinical Neurology
Alberto Raggi, Lorenzo Monasta, Ettore Beghi, Valeria Caso, Giulio Castelpietra, Stefania Mondello, Giorgia Giussani, Giancarlo Logroscino, Francesca Giulia Magnani, Marco Piccininni, Elisabetta Pupillo, Stefano Ricci, Luca Ronfani, Paola Santalucia, Davide Sattin, Silvia Schiavolin, Claudia Toppo, Eugenio Traini, Jaimie Steinmetz, Emma Nichols, Rui Ma, Theo Vos, Valery Feigin, Matilde Leonardi
Summary: The study shows that the incidence and prevalence of neurological conditions in Italy are increasing, mainly due to population aging and growth. Years lived with disability associated with neurological conditions have significantly increased, calling for actions to improve the situation.
JOURNAL OF NEUROLOGY
(2022)
Review
Spectroscopy
Wenjing Peng, Cristian D. Gutierrez Reyes, Sakshi Gautam, Aiying Yu, Byeong Gwan Cho, Mona Goli, Kaitlyn Donohoo, Stefania Mondello, Firas Kobeissy, Yehia Mechref
Summary: Glycosylation is a significant posttranslational modification in mammalian cells, involved in various biofunctions and diseases. Mass spectrometry is a powerful tool for glycan and glycopeptide isomeric analysis, but its comprehensive characterization remains a challenge. Separation methods and bioinformatic tools are applied to address this challenge.
MASS SPECTROMETRY REVIEWS
(2023)
Review
Genetics & Heredity
Alessio Ardizzone, Anna Paola Capra, Stefania Mondello, Silvana Briuglia, Maria Angela La Rosa, Michela Campolo, Emanuela Esposito
Summary: Recurrent pregnancy loss (RPL) is the loss of two or more pregnancies, affecting approximately 1 to 3% of women worldwide. There is a possible correlation between thrombophilic genetic variants and RPL, but the data are often conflicting. Further investigations evaluating genotype-phenotype correlations can improve clinical management and genetic counseling.
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Elena Pallari, Vanessa Gorasso, Elena von der Lippe, Brecht Devleesschauwer, Sara M. Pires, Dietrich Plass, Jane Idavain, Che Henry Ngwa, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, Marek Majdan, Balazs adam, Ala'a AlKerwi, Seila Cilovic-Lagarija, Benjamin Clarsen, Barbara Corso, Sarah Cuschieri, Keren Dopelt, Mary Economou, Florian Fischer, Alberto Freitas, Juan Manuel Garcia-Gonzalez, Federica Gazzelloni, Artemis Gkitakou, Hakan Gulmez, Paul Hynds, Gaetano Isola, Lea S. Jakobsen, Zubair Kabir, Katarzyna Kissimova-Skarbek, Ann Kristin Knudsen, Naime Meric Konar, Carina Ladeira, Brian Lassen, Aaron Liew, Marjeta Majer, Enkeleint A. Mechili, Alibek Mereke, Lorenzo Monasta, Stefania Mondello, Joana Nazare Morgado, Evangelia Nena, Edmond S. W. Ng, Vikram Niranjan, Iskra Alexandra Nola, Ronan O'Caoimh, Panagiotis Petrou, Vera Pinheiro, Miguel Reina Ortiz, Silvia Riva, Hanen Samouda, Joao Vasco Santos, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Dimitrios Skempes, Ana Catarina Sousa, Niko Speybroeck, Fimka Tozija, Brigid Unim, Hilal Bektas Uysal, Fabrizio Giovanni Vaccaro, Orsolya Varga, Milena Vasic, Francesco Saverio Violante, Grant M. A. Wyper, Suzanne Polinder, Juanita A. Haagsma
Summary: This systematic literature review examines the methodological design choices in burden of disease studies on injury populations in Europe. The study found considerable methodological variation in the calculation of years lived with disability, implementation of disability weights, and choice of life table for years of life lost. The development and use of guidelines for performing and reporting injury burden of disease studies are crucial for enhancing transparency and comparability across Europe and beyond.
Article
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David K. Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio
Summary: This study investigated the impact of high arterial oxygen levels and supplemental oxygen on outcomes in TBI patients admitted to the ICU. It found that exposure to high blood oxygen levels was independently associated with higher mortality rates at 6 months. Additionally, the severity of brain injury did not change the relationship between high arterial oxygen levels and outcomes.
INTENSIVE CARE MEDICINE
(2022)
Article
Clinical Neurology
Isabel R. A. Retel Helmrich, Endre Czeiter, Krisztina Amrein, Andras Buki, Hester F. Lingsma, David K. Menon, Stefania Mondello, Ewout W. Steyerberg, Nicole von Steinbuchel, Kevin K. W. Wang, Lindsay Wilson, Haiyan Xu, Zhihui Yang, David van Klaveren, Andrew I. R. Maas
Summary: This study aimed to examine the value of serum biomarkers in predicting functional outcome after traumatic brain injury. The results showed that higher levels of serum biomarkers were associated with worse outcome, and adding them to established prognostic models improved the prediction accuracy, with UCH-L1 showing the greatest prognostic value.
Review
Public, Environmental & Occupational Health
Periklis Charalampous, Juanita A. Haagsma, Lea S. Jakobsen, Vanessa Gorasso, Isabel Noguer, Alicia Padron-Monedero, Rodrigo Sarmiento, Joao Vasco Santos, Scott A. McDonald, Dietrich Plass, Grant M. A. Wyper, Ricardo Assuncao, Elena von der Lippe, Balazs Adam, Ala'a AlKerwi, Jalal Arabloo, Ana Lucia Baltazar, Boris Bikbov, Maria Borrell-Pages, Iris Brus, Genc Burazeri, Serafeim C. Chaintoutis, Jose Chen-Xu, Nino Chkhaberidze, Seila Cilovic-Lagarija, Barbara Corso, Sarah Cuschieri, Carlotta Di Bari, Keren Dopelt, Mary Economou, Theophilus Emeto, Peter Fantke, Florian Fischer, Alberto Freitas, Juan Manuel Garcia-Gonzalez, Federica Gazzelloni, Mika Gissler, Artemis Gkitakou, Hakan Gulmez, Sezgin Gunes, Sebastian Haller, Romana Haneef, Cesar A. Hincapie, Paul Hynds, Jane Idavain, Milena Ilic, Irena Ilic, Gaetano Isola, Zubair Kabir, Maria Kamusheva, Pavel Kolkhir, Naime Meric Konar, Polychronis Kostoulas, Mukhtar Kulimbet, Carlo La Vecchia, Paolo Lauriola, Miriam Levi, Marjeta Majer, Enkeleint A. Mechili, Lorenzo Monasta, Stefania Mondello, Javier Munoz Laguna, Evangelia Nena, Edmond S. W. Ng, Paul Nguewa, Vikram Niranjan, Iskra Alexandra Nola, Ronan O'Caoimh, Marija Obradovic, Elena Pallari, Mariana Peyroteo, Vera Pinheiro, Nurka Pranjic, Miguel Reina Ortiz, Silvia Riva, Cornelia Melinda Adi Santoso, Milena Santric Milicevic, Tugce Schmitt, Niko Speybroeck, Maximilian Sprugel, Paschalis Steiropoulos, Aleksandar Stevanovic, Lau Caspar Thygesen, Fimka Tozija, Brigid Unim, Hilal Bektas Uysal, Orsolya Varga, Milena Vasic, Rafael Jose Vieira, Vahit Yigit, Brecht Devleesschauwer, Sara M. Pires
Summary: This systematic literature review provides an overview of studies applying the disability-adjusted life years (DALY) concept for infectious diseases in European countries. Among the 105 included studies, food- and water-borne diseases were the most frequently studied. The number of burden of infectious disease studies has increased over time, but there is less consensus in methodological approaches.
EPIDEMIOLOGY AND INFECTION
(2023)
Editorial Material
Clinical Neurology
Anastasia Bougea, Per Svenningsson, Ioanna Markaki, Abdul Hye, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akeem Sanni, Mona Goli, Jingfu Zhao, Junyao Wang, Chloe Barsa, Samer El Hayek, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, Yehia Mechref
Summary: This study aimed to identify potential serum biomarkers for narcolepsy type 1 (NT1), a life-threatening disorder characterized by a sleep-wake cycle disorder. A proteomics analysis was conducted, which revealed 36 differentially expressed proteins associated with NT1. These findings provide insights into the pathophysiological effects and important biochemical pathways involved in NT1.
Editorial Material
Clinical Neurology
Wael M. Y. Mohamed, Firas Kobeissy, Stefania Mondello
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sara Conti, Carla Fornari, Pietro Ferrara, Ippazio C. Antonazzo, Fabiana Madotto, Eugenio Traini, Miriam Levi, Achille Cernigliaro, Benedetta Armocida, Nicola L. Bragazzi, Ennio Cadum, Michele Carugno, Giacomo Crotti, Silvia Deandrea, Paolo A. Cortesi, Davide Guido, Ivo Iavicoli, Sergio Iavicoli, Carlo La Vecchia, Paolo Lauriola, Paola Michelozzi, Salvatore Scondotto, Massimo Stafoggia, Francesco S. Violante, Cristiana Abbafati, Luciana Albano, Francesco Barone-Adesi, Antonio Biondi, Cristina Bosetti, Danilo Buonsenso, Giulia Carreras, Giulio Castelpietra, Alberico Catapano, Maria S. Cattaruzza, Barbara Corso, Giovanni Damiani, Francesco Esposito, Silvano Gallus, Davide Golinelli, Simon I. Hay, Gaetano Isola, Caterina Ledda, Stefania Mondello, Paolo Pedersini, Umberto Pensato, Norberto Perico, Giuseppe Remuzzi, Francesco Sanmarchi, Rocco Santoro, Biagio Simonetti, Brigid Unim, Marco Vacante, Massimiliano Veroux, Jorge H. Villafane, Lorenzo Monasta, Lorenzo G. Mantovani
Summary: We investigated the temporal variations in disease burden of PM2.5 and ozone in Italy using data from the Global Burden of Disease Study 2019. The study found that while the burden of PM2.5 significantly decreased in Italy, the burden of ozone increased, even in the context of population aging.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Meeting Abstract
Critical Care Medicine
Hannah Radabaugh, Stefania Mondello, Patrick Kochanek, C. Edward Dixon, Deborah Shear, Kevin Wang, Ronald Hayes, Adam Ferguson, W. Dalton Dietrich, Helen Bramlett
JOURNAL OF NEUROTRAUMA
(2022)
Article
Medicine, General & Internal
Stefania Mondello, Viktor Sandner, Mona Goli, Endre Czeiter, Krisztina Amrein, Patrick M. Kochanek, Sakshi Gautam, Byeong Gwan Cho, Ryan Morgan, Ali Nehme, Giacomo Fiumara, Ali H. Eid, Chloe Barsa, Muhammad Ali Haidar, Andras Buki, Firas H. Kobeissy, Yehia Mechref
Summary: This study provides initial evidence supporting the utility of glycomics approaches for biomarker discovery and patient phenotyping in traumatic brain injury (TBI). Further large-scale studies are needed to validate these findings and determine their potential applications in clinical practice.
Article
Medicine, General & Internal
Group Author Only
Summary: Based on the data analysis of GBD 2019, the global population of older adults has increased since 1990, and overall mortality rates have decreased for both men and women. However, mortality rates due to falls have increased during the same period. The probability of death among people aged 70-90 has decreased, mainly due to reductions in non-communicable diseases. Globally, disability burden is mainly driven by functional decline, vision and hearing loss, and symptoms of pain. Life expectancy at age 70 (LE-70) and healthy life expectancy at age 70 (HALE-70) have shown continuous increases since 1990, with regional disparities. Higher LE-70 results in higher HALE-70 and slightly increased proportion of years in ill health at age 70 (PYIH-70). Sociodemographic factors, healthcare access and quality indices are positively correlated with HALE-70 and LE-70. Limited data are available for various dietary, environmental or occupational, and metabolic risks.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
