Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

(2019) Roxana Aldea et al.   Frontiers in Aging Neuroscience

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

(2019) Angeliki M. Nikolakopoulou et al.   NATURE NEUROSCIENCE

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

(2019) Luis Alarcon-Martinez et al.   Acta Neuropathologica Communications

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization

(2018) Lila Khennouf et al.   BRAIN

In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain

(2018) Kassandra Kisler et al.   Nature Protocols

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

(2018) Luis Alarcon-Martinez et al.   eLife

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types

(2018) Liqun He et al.   Scientific Data

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy

(2017) Elena Ivanova et al.   JOURNAL OF NEUROSCIENCE

Pericytes impair capillary blood flow and motor function after chronic spinal cord injury

(2017) Yaqing Li et al.   NATURE MEDICINE

A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging

(2017) Eyiyemisi C Damisah et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Cochlear Pericytes Are Capable of Reversibly Decreasing Capillary Diameter In Vivo After Tumor Necrosis Factor Exposure

(2017) Mattis Bertlich et al.   OTOLOGY & NEUROTOLOGY

Role of clusterin in the brain vascular clearance of amyloid-β

(2017) Amy R. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility

(2017) Callum M. Johnston et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Novel method to study pericyte contractility and responses to ischaemia in vitro using electrical impedance

(2016) Ain A Neuhaus et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

(2016) Helen Shinru Wei et al.   NEURON

A Simulation Model of Periarterial Clearance of Amyloid-β from the Brain

(2016) Alexandra K. Diem et al.   Frontiers in Aging Neuroscience

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood−brain barrier permeability: Possible link to postoperative delirium and cognitive decline

(2015) Nimish K. Acharya et al.   BRAIN RESEARCH

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia

(2015) Francisco Fernandez-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

(2012) Kazuto Masamoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Line-Scanning Particle Image Velocimetry: An Optical Approach for Quantifying a Wide Range of Blood Flow Speeds in Live Animals

(2012) Tyson N. Kim et al.   PLoS One

Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS

(2011) Min Dai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Label-free optical control of arterial contraction

(2010) Myunghwan Choi et al.   JOURNAL OF BIOMEDICAL OPTICS

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament

(2009) Min Dai et al.   HEARING RESEARCH