Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

(2015) Martin Nors Pedersen et al.   Scientific Reports

Protein/Lipid Coaggregates are Formed During α-Synuclein-Induced Disruption of Lipid Bilayers

(2014) Andreas van Maarschalkerweerd et al.   BIOMACROMOLECULES

α-Synuclein oligomers distinctively permeabilize complex model membranes

(2014) Anja N. D. Stefanovic et al.   FEBS Journal

How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

(2014) Nikolai Lorenzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane–Protein Interactions Are Key to Understanding Amyloid Formation

(2014) John E. Straub et al.   Journal of Physical Chemistry Letters

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Cholesterol level affects surface charge of lipid membranes in saline solution

(2014) Aniket Magarkar et al.   Scientific Reports

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: Templation and inhibition involve oligomers with different structure

(2013) Istvan Horvath et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation

(2013) Zhiping Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

Differential Dynamic and Structural Behavior of Lipid-Cholesterol Domains in Model Membranes

(2012) Luis F. Aguilar et al.   PLoS One

Fluctuation Methods To Study Protein Aggregation in Live Cells: Concanavalin A Oligomers Formation

(2011) V. Vetri et al.   BIOPHYSICAL JOURNAL

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1

(2011) Monica Bucciantini et al.   FASEB JOURNAL

Quantitative imaging of membrane lipid order in cells and organisms

(2011) Dylan M Owen et al.   Nature Protocols

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity

(2010) Massimo Stefani   FEBS Journal

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Lipid bilayer disruption by oligomeric α-synuclein depends on bilayer charge and accessibility of the hydrophobic core

(2009) Bart D. van Rooijen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

(2009) Lynette Cegelski et al.   Nature Chemical Biology

Impact of cholesterol level upon APP and BACE proximity and APP cleavage

(2008) Christine A.F. von Arnim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS