Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Effect of statins on Parkinsonʼs disease

(2019) Junqiang Yan et al.   MEDICINE

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

The role of ABCA7 in Alzheimer’s disease: evidence from genomics, transcriptomics and methylomics

(2019) Arne De Roeck et al.   ACTA NEUROPATHOLOGICA

Association of statin use with Parkinson's disease: Dose–response relationship

(2019) Su‐Min Jeong et al.   MOVEMENT DISORDERS

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Dopamine Burden Triggers Cholesterol Overload Following Disruption of Synaptogenesis in Minimal Hepatic Encephalopathy

(2019) Weishan Zhuge et al.   NEUROSCIENCE

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities

(2019) Naomi P. Visanji et al.   Translational Neurodegeneration

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

(2019) Yu An et al.   Molecular Neurodegeneration

Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial

(2018) Anna Rosenberg et al.   Alzheimers & Dementia

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

(2018) Jared Schommer et al.   BMC NEUROSCIENCE

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

(2018) Talia Zeppelin et al.   PLoS Computational Biology

Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease

(2018) Laura Mateos et al.   JOURNAL OF ALZHEIMERS DISEASE

Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death

(2018) Saleta Sierra et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study

(2018) Violetta Rozani et al.   MOVEMENT DISORDERS

Dietary changes and cognition over 2 years within a multidomain intervention trial—The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

(2018) Jenni Lehtisalo et al.   Alzheimers & Dementia

Impact of high cholesterol in a Parkinson’s disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation

(2017) Ida Eriksson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis

(2017) Kaarin J. Anstey et al.   JOURNAL OF ALZHEIMERS DISEASE

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

(2017) Muhammad-Al-Mustafa Ismail et al.   JOURNAL OF EXPERIMENTAL MEDICINE

α-Synuclein Interacts with Lipoproteins in Plasma

(2017) Fatemeh Nouri Emamzadeh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein Regulates Neuronal Cholesterol Efflux

(2017) Jen-Hsiang Hsiao et al.   MOLECULES

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

(2017) Guodong Liu et al.   MOVEMENT DISORDERS

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Leptin Reduces the Accumulation of Aβ and Phosphorylated Tau Induced by 27-Hydroxycholesterol in Rabbit Organotypic Slices

(2017) Gurdeep Marwarha et al.   JOURNAL OF ALZHEIMERS DISEASE

Statin adherence and the risk of Parkinson's disease: A population-based cohort study

(2017) Violetta Rozani et al.   PLoS One

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats

(2016) Aurélie Ledreux et al.   BEHAVIOURAL BRAIN RESEARCH

Statin use and risk of Parkinson’s disease: A meta-analysis

(2016) Zhiguo Sheng et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease

(2016) Fatemeh Nouri Emamzadeh et al.   NEUROSCIENCE LETTERS

High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice

(2016) Peter Thériault et al.   Oncotarget

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

(2016) Gabriella Testa et al.   Redox Biology

Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis

(2016) Shuang Bai et al.   PLoS One

27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice

(2015) Maura Heverin et al.   BEHAVIOURAL BRAIN RESEARCH

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

(2015) Gurdeep Marwarha et al.   EXPERIMENTAL GERONTOLOGY

Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

(2015) Andreas van Maarschalkerweerd et al.   FEBS LETTERS

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Early Statin Use and the Progression of Alzheimer Disease

(2015) Feng-Cheng Lin et al.   MEDICINE

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

(2015) Xuemei Huang et al.   MOVEMENT DISORDERS

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients

(2015) Christine R. Swanson et al.   MOVEMENT DISORDERS

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies

(2015) Keiko Nakamura et al.   NEUROPATHOLOGY

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

(2015) Paola Gamba et al.   Frontiers in Aging Neuroscience

Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

(2014) M. G. Martin et al.   EMBO Molecular Medicine

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain

(2014) Ahmed A. Saeed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin

(2014) Jean E. Vance et al.   JOURNAL OF LIPID RESEARCH

Simvastatin prevents neuroinflammation by inhibiting N-methyl-D-aspartic acid receptor 1 in 6-hydroxydopamine-treated PC12 cells

(2014) Junqiang Yan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alpha synuclein is transported into and out of the brain by the blood–brain barrier

(2014) Yu-Ting Sui et al.   PEPTIDES

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

(2014) K Yamanaka et al.   Cell Death & Disease

Plasma apolipoprotein A1 as a biomarker for Parkinson disease

(2013) Judy K. Qiang et al.   ANNALS OF NEUROLOGY

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

(2013) Jo V. Rushworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic andCyp27a1−/−mice

(2013) Zeina Ali et al.   JOURNAL OF LIPID RESEARCH

Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

(2013) D. Boassa et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice

(2013) Jade de Oliveira et al.   NEUROCHEMICAL RESEARCH

Discontinuation of statin therapy associates with Parkinson disease: A population-based study

(2013) Y.-C. Lee et al.   NEUROLOGY

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

(2013) Ingemar Björkhem et al.   NEUROSCIENCE LETTERS

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients

(2013) Qiang Wei et al.   PLoS One

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Cholesterol homeostasis: a key to prevent or slow down neurodegeneration

(2013) Laura Anchisi et al.   Frontiers in Physiology

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

(2012) J. E. Vance   Disease Models & Mechanisms

Importance of cholesterol in dopamine transporter function

(2012) Kymry T. Jones et al.   JOURNAL OF NEUROCHEMISTRY

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

Strong preferences of dopamine and l-dopa towards lipid head group: importance of lipid composition and implication for neurotransmitter metabolism

(2012) Adam Orłowski et al.   JOURNAL OF NEUROCHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

(2012) C Pottier et al.   MOLECULAR PSYCHIATRY

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

A large study reveals no association between APOE and Parkinson's disease

(2012) Monica Federoff et al.   NEUROBIOLOGY OF DISEASE

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain

(2011) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Plasma cholesterol and risk for late-onset Alzheimer’s disease

(2011) Angel Cedazo-Mínguez et al.   Expert Review of Neurotherapeutics

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism

(2011) Laura Mateos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

(2011) Kazunori Yamanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

(2011) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Apolipoprotein E genotypes and the risk of Parkinson disease

(2011) Jianjun Gao et al.   NEUROBIOLOGY OF AGING

Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses

(2011) Junqiang Yan et al.   PLoS One

Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

(2010) Jill K. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E receptors in the nervous system

(2009) Joachim Herz   CURRENT OPINION IN LIPIDOLOGY

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

(2009) Andrew O. Koob et al.   EXPERIMENTAL NEUROLOGY

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

(2009) Katja Nieweg et al.   JOURNAL OF NEUROCHEMISTRY

Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s Disease

(2009) C. H. Williams-Gray et al.   JOURNAL OF NEUROLOGY

Oxysterols and neurodegenerative diseases

(2009) Ingemar Björkhem et al.   MOLECULAR ASPECTS OF MEDICINE

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

(2009) Jaya RP Prasanthi et al.   Molecular Neurodegeneration

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

(2009) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress

(2008) Chung-Yung J. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Dietin vivoand by 27-Hydroxycholesterolin vitro

(2008) Laura Mateos et al.   BRAIN PATHOLOGY

Plasma Lipid Levels in the Elderly Are Not Associated with the Risk of Mild Cognitive Impairment

(2008) Christiane Reitz et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

(2008) Woojin Scott Kim et al.   JOURNAL OF NEUROCHEMISTRY

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells

(2008) Jaya Prasanthi Rantham Prabhakara et al.   JOURNAL OF NEUROCHEMISTRY

Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease

(2008) Pazit Bar-On et al.   JOURNAL OF NEUROCHEMISTRY

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Statin use and the risk of Parkinson disease

(2008) A. D. Wahner et al.   NEUROLOGY

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Regulation of α-synuclein expression by liver X receptor ligands in vitro

(2008) Danni Cheng et al.   NEUROREPORT

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE