The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
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Title
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Authors
Keywords
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Journal
Molecular Cancer
Volume 20, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-18
DOI
10.1186/s12943-020-01263-w
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Note: Only part of the references are listed.- The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB
- (2020) Sasithorn Wanna-udom et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
- (2020) Shuo Chen et al. Cancer Cell International
- A prospective analysis of circulating plasma metabolites associated with ovarian cancer risk
- (2020) Oana A Zeleznik et al. CANCER RESEARCH
- Level of N6-Methyladenosine in Peripheral Blood RNA: A Novel Predictive Biomarker for Gastric Cancer
- (2020) Lichen Ge et al. CLINICAL CHEMISTRY
- METTL3/YTHDF2 m 6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer
- (2020) Haiyun Xie et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- RNA m 6 A methylation regulates uveal melanoma cell proliferation, migration, and invasion by targeting c‐Met
- (2020) Guangying Luo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
- (2020) Bo Tang et al. Molecular Cancer
- METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
- (2020) Xiao Yang et al. Molecular Cancer
- m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC
- (2020) Dan Jin et al. Molecular Cancer
- The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
- (2020) Tao Liu et al. NUCLEIC ACIDS RESEARCH
- Effect of m6A RNA Methylation Regulators on Malignant Progression and Prognosis in Renal Clear Cell Carcinoma
- (2020) Jiawu Wang et al. Frontiers in Oncology
- Five Genes Associated With Survival in Patients With Lower-grade Gliomas Were Identified by Information-theoretical Analysis
- (2020) KEIKO SATO et al. ANTICANCER RESEARCH
- RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
- (2020) Chao Shen et al. Cell Stem Cell
- Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells
- (2020) Fanhua Kong et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF‐ κ B pathway
- (2020) Yi Jiang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Stemming the tide of drug resistance in cancer
- (2020) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Emerging roles of novel small non-coding regulatory RNAs in immunity and cancer
- (2020) Domenico Rosace et al. RNA Biology
- RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner
- (2020) Lin Mei et al. Cell Death & Disease
- Down-regulation of FTO promotes proliferation and migration, and protects bladder cancer cells from cisplatin-induced cytotoxicity
- (2020) Lijie Wen et al. BMC Urology
- Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer
- (2020) Artem Babaian et al. Cell Reports
- The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression
- (2020) Shuiping Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
- (2020) Sara Zaccara et al. CELL
- Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome
- (2020) Sara Cherry et al. GENES & DEVELOPMENT
- Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
- (2019) Yue Li et al. DIGESTIVE DISEASES AND SCIENCES
- Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies
- (2019) Yuri Motorin et al. Genes
- Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
- (2019) Dali Han et al. NATURE
- Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
- (2019) Huilin Huang et al. NATURE
- RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
- (2019) Yi Niu et al. Molecular Cancer
- RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2
- (2019) Ujwal Dahal et al. MELANOMA RESEARCH
- Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma
- (2019) Gokul Sridharan et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Increased DKC1 expression in glioma and its significance in tumor cell proliferation, migration and invasion
- (2019) Fa-an Miao et al. INVESTIGATIONAL NEW DRUGS
- Oncogenic Y‐box binding protein‐1 ( YBX 1) as an effective therapeutic target in drug‐resistant cancer
- (2019) Michihiko Kuwano et al. CANCER SCIENCE
- Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database
- (2019) Jingcheng Zhou et al. Aging-US
- Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
- (2019) Yue Huang et al. CANCER CELL
- Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
- (2019) Jasmin Paris et al. Cell Stem Cell
- ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2
- (2019) Hongtao Zhu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1
- (2019) Yingmin Wu et al. Molecular Cancer
- The role of m6A RNA methylation in human cancer
- (2019) Xiao-Yu Chen et al. Molecular Cancer
- The RNA N6-methyladenosine modification landscape of human fetal tissues
- (2019) Shan Xiao et al. NATURE CELL BIOLOGY
- Genome-wide identification of mRNA 5-methylcytosine in mammals
- (2019) Tao Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
- (2019) Jialiang Zhang et al. Nature Communications
- Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies
- (2019) Wei Li et al. Oncology Research and Treatment
- YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
- (2019) Yang Bai et al. Frontiers in Oncology
- Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
- (2019) Antonella Carella et al. INTERNATIONAL JOURNAL OF CANCER
- The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway
- (2019) Dongkui Gong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
- (2019) Jun Zhang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
- (2019) Jie Han et al. Molecular Cancer
- METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
- (2019) Ting Li et al. Molecular Cancer
- 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs
- (2019) Xin Chen et al. NATURE CELL BIOLOGY
- Reading canonical and modified nucleobases in 16S ribosomal RNA using nanopore native RNA sequencing
- (2019) Andrew M. Smith et al. PLoS One
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
- (2019) Seungwon Yang et al. Nature Communications
- Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation
- (2019) Abdulrahim A. Sajini et al. Nature Communications
- RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
- (2019) Xinyao Lin et al. Nature Communications
- Detailed modeling of positive selection improves detection of cancer driver genes
- (2019) Siming Zhao et al. Nature Communications
- Cytosine-5 RNA methylation links protein synthesis to cell metabolism
- (2019) Nikoletta A. Gkatza et al. PLOS BIOLOGY
- Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
- (2019) Maxime Janin et al. ACTA NEUROPATHOLOGICA
- The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1
- (2019) Wujun Miao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NOP 2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL 6 in gallbladder carcinoma
- (2019) Yuan Gao et al. CANCER SCIENCE
- YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation
- (2019) Hao Sheng et al. CARCINOGENESIS
- Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
- (2019) Wen Peng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- mRNA structure determines modification by pseudouridine synthase 1
- (2019) Thomas M. Carlile et al. Nature Chemical Biology
- DART-seq: an antibody-free method for global m6A detection
- (2019) Kate D. Meyer NATURE METHODS
- A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS
- (2019) Mary McMahon et al. eLife
- N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer
- (2019) Huan Jin et al. EBioMedicine
- METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
- (2019) Ben Yue et al. Molecular Cancer
- Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3
- (2019) Wen Ni et al. Molecular Cancer
- Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
- (2019) Chaohui Gu et al. Molecular Cancer
- m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation
- (2019) Ruobing Jia et al. Molecular Cancer
- METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
- (2019) Xiaoxiang Chen et al. MOLECULAR THERAPY
- Pseudouridinylation of mRNA coding sequences alters translation
- (2019) Daniel E. Eyler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway
- (2019) Jiarong Cai et al. OncoTargets and Therapy
- Accurate detection of m6A RNA modifications in native RNA sequences
- (2019) Huanle Liu et al. Nature Communications
- Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma
- (2019) Lilit Nersisyan et al. Frontiers in Oncology
- The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells
- (2019) Dongling Zou et al. Cancer Cell International
- m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
- (2019) Dan Jin et al. Journal of Hematology & Oncology
- N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1
- (2019) Hongsheng Wang et al. Molecular Cancer
- Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation
- (2019) Jinghui Song et al. Nature Chemical Biology
- 2-Oxoglutarate-Dependent Oxygenases
- (2018) Md. Saiful Islam et al. Annual Review of Biochemistry
- m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression
- (2018) Jiqin Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma
- (2018) Lingeng Lu et al. CANCER INVESTIGATION
- Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma
- (2018) Yuan Li et al. CANCER LETTERS
- HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
- (2018) Xiaoli Cai et al. CANCER LETTERS
- SnapShot: Messenger RNA Modifications
- (2018) Veronica Davalos et al. CELL
- Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
- (2018) Nicola Guzzi et al. CELL
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation
- (2018) Yuan He et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
- (2018) Philip Knuckles et al. GENES & DEVELOPMENT
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation
- (2018) Shun Zhou et al. MOLECULAR CARCINOGENESIS
- Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
- (2018) Qicong Shen et al. NATURE
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Highly parallel direct RNA sequencing on an array of nanopores
- (2018) Daniel R Garalde et al. NATURE METHODS
- RNA-modifying proteins as anticancer drug targets
- (2018) P. Ann Boriack-Sjodin et al. NATURE REVIEWS DRUG DISCOVERY
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential
- (2018) Dandan Yang et al. NUCLEIC ACIDS RESEARCH
- Beyond molecular tumor heterogeneity: protein synthesis takes control
- (2018) Santiago Ramon y Cajal et al. ONCOGENE
- Translational Control in Cancer
- (2018) Nathaniel Robichaud et al. Cold Spring Harbor Perspectives in Biology
- Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
- (2018) Baixing Wu et al. Nature Communications
- RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
- (2018) Jason X. Cheng et al. Nature Communications
- Tapping the RNA world for therapeutics
- (2018) Judy Lieberman NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Epigenetic dysregulation of TET2 in human glioblastoma
- (2018) María G. García et al. Oncotarget
- METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition
- (2018) Wenfeng Hua et al. GYNECOLOGIC ONCOLOGY
- Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor
- (2018) Katelyn A. Doxtader et al. MOLECULAR CELL
- Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development
- (2018) Mateusz Mendel et al. MOLECULAR CELL
- Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
- (2018) Jiangbo Wei et al. MOLECULAR CELL
- Codon-specific translation reprogramming promotes resistance to targeted therapy
- (2018) Francesca Rapino et al. NATURE
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- The m6A-methylase complex recruits TREX and regulates mRNA export
- (2018) Simon Lesbirel et al. Scientific Reports
- A novel m6A reader Prrc2a controls oligodendroglial specification and myelination
- (2018) Rong Wu et al. CELL RESEARCH
- DNA Methyltransferase Inhibitors and Their Therapeutic Potential
- (2018) Zehao Zhou et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Homology Model and Docking-Based Virtual Screening for Ligands of Human Dyskerin as New Inhibitors of Telomerase for Cancer Treatment
- (2018) Romina Armando et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation
- (2018) Xiang Zhong et al. Cell Reports
- YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
- (2018) Li Zhong et al. CANCER LETTERS
- Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival
- (2017) Jia-cheng Yang et al. Future Oncology
- m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
- (2017) Shengdong Ke et al. GENES & DEVELOPMENT
- TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code
- (2017) Modi Safra et al. GENOME RESEARCH
- Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs
- (2017) Carine Legrand et al. GENOME RESEARCH
- Nuclear expression of Y box binding-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer
- (2017) Takahisa Yamashita et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein
- (2017) Zhe Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
- (2017) Chau-To Kwok et al. Journal of Hematology & Oncology
- Tailor-Made Molecularly Imprinted Polymer for Selective Recognition of the Urinary Tumor Marker Pseudouridine
- (2017) Aleksandra Krstulja et al. MACROMOLECULAR BIOSCIENCE
- 5-Methylcytosine RNA Methylation in Arabidopsis Thaliana
- (2017) Xuean Cui et al. Molecular Plant
- Visualization of chemical modifications in the human 80S ribosome structure
- (2017) S. Kundhavai Natchiar et al. NATURE
- RNA m6A methylation regulates the ultraviolet-induced DNA damage response
- (2017) Yang Xiang et al. NATURE
- Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
- (2017) Isaia Barbieri et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
- (2017) Nian Liu et al. NUCLEIC ACIDS RESEARCH
- MODOMICS: a database of RNA modification pathways. 2017 update
- (2017) Pietro Boccaletto et al. NUCLEIC ACIDS RESEARCH
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers
- (2017) Su Yeon Yeon et al. PATHOLOGY & ONCOLOGY RESEARCH
- Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs
- (2017) Rakesh David et al. PLANT CELL
- Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?
- (2017) Anne C. Rintala-Dempsey et al. RNA Biology
- The RNA modification landscape in human disease
- (2017) Nicky Jonkhout et al. RNA
- Reciprocal amplification of caspase-3 activity by nuclear export of a putative human RNA-modifying protein, PUS10 during TRAIL-induced apoptosis
- (2017) Sujata Jana et al. Cell Death & Disease
- Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
- (2017) Shawn M. Lyons et al. Nature Communications
- Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
- (2017) Yujiro Nishizawa et al. Oncotarget
- The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma
- (2017) Xiao Li et al. Oncotarget
- Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs
- (2017) Chan Zhou et al. Cell Reports
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility
- (2017) Joana V. Flores et al. Stem Cell Reports
- AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
- (2017) Yuko Ueda et al. Scientific Reports
- Clonal hematopoiesis in patients with dyskeratosis congenita
- (2016) Nieves Perdigones et al. AMERICAN JOURNAL OF HEMATOLOGY
- Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics
- (2016) Natalie P. Archer et al. CANCER
- RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated
- (2016) Atsushi Tanabe et al. CANCER LETTERS
- Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression
- (2016) Hani Goodarzi et al. CELL
- Post-transcriptional modifications in development and stem cells
- (2016) Michaela Frye et al. DEVELOPMENT
- NSUN3 and ABH1 modify the wobble position of mt‐tRNAMetto expand codon recognition in mitochondrial translation
- (2016) Sara Haag et al. EMBO JOURNAL
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1
- (2016) Juyeong Hong et al. JOURNAL OF CELL SCIENCE
- Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer
- (2016) Sylvain Delaunay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
- (2016) Wen Xiao et al. MOLECULAR CELL
- Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
- (2016) Ping Wang et al. MOLECULAR CELL
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- Stem cell function and stress response are controlled by protein synthesis
- (2016) Sandra Blanco et al. NATURE
- Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2016) Xiang Wang et al. NATURE
- Reversible methylation of m6Am in the 5′ cap controls mRNA stability
- (2016) Jan Mauer et al. NATURE
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet
- (2016) Saori Nakano et al. Nature Chemical Biology
- The molecular hallmarks of epigenetic control
- (2016) C. David Allis et al. NATURE REVIEWS GENETICS
- Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA
- (2016) Jessica A. Brown et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function
- (2016) Katherine E. Sloan et al. RNA Biology
- tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
- (2016) Yok Hian Chionh et al. Nature Communications
- YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
- (2016) Hao Du et al. Nature Communications
- Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3
- (2016) Lindsey Van Haute et al. Nature Communications
- Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
- (2016) S. P. Kar et al. Cancer Discovery
- Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells
- (2016) Chuanzhao Zhang et al. Oncotarget
- mRNA methylation by NSUN2 in cell proliferation
- (2016) Wengong Wang Wiley Interdisciplinary Reviews-RNA
- Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties
- (2015) Winfried Elhardt et al. BIOCHIMIE
- Conservation of tRNA and rRNA 5-methylcytosine in the kingdom Plantae
- (2015) Alice Louise Burgess et al. BMC PLANT BIOLOGY
- 5′ UTR m6A Promotes Cap-Independent Translation
- (2015) Kate D. Meyer et al. CELL
- HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
- (2015) Claudio R. Alarcón et al. CELL
- m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
- (2015) Tong Chen et al. Cell Stem Cell
- Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
- (2015) Francesca Aguilo et al. Cell Stem Cell
- Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes
- (2015) Clement T. Y. Chan et al. CHEMICAL RESEARCH IN TOXICOLOGY
- The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis
- (2015) F. Tuorto et al. EMBO JOURNAL
- Human ribosomes from cells with reduced dyskerin levels are intrinsically altered in translation
- (2015) Marianna Penzo et al. FASEB JOURNAL
- A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
- (2015) Shengdong Ke et al. GENES & DEVELOPMENT
- RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation
- (2015) Yanan Yue et al. GENES & DEVELOPMENT
- Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
- (2015) Caroline Roost et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- N6-methyladenosine marks primary microRNAs for processing
- (2015) Claudio R. Alarcón et al. NATURE
- Dynamic m6A mRNA methylation directs translational control of heat shock response
- (2015) Jun Zhou et al. NATURE
- N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
- (2015) Nian Liu et al. NATURE
- Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome
- (2015) Xiaoyu Li et al. Nature Chemical Biology
- Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
- (2015) Bastian Linder et al. NATURE METHODS
- Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures
- (2015) Michael H. Schwartz et al. NUCLEIC ACIDS RESEARCH
- NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs
- (2015) Sara Haag et al. RNA
- m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
- (2015) Shay Geula et al. SCIENCE
- Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
- (2015) Markus Schosserer et al. Nature Communications
- Dyskerin and TERC expression may condition survival in lung cancer patients
- (2015) Marianna Penzo et al. Oncotarget
- Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120
- (2015) Gabrielle Bourgeois et al. PLoS One
- Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides
- (2015) Eikan Mishima et al. PLoS One
- Pseudouridine: Still mysterious, but never a fake (uridine)!
- (2015) Felix Spenkuch et al. RNA Biology
- Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
- (2014) Schraga Schwartz et al. CELL
- Pseudouridine in a new era of RNA modifications
- (2014) Boxuan Simen Zhao et al. CELL RESEARCH
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition
- (2014) Fudong Li et al. CELL RESEARCH
- Role of RNA methyltransferases in tissue renewal and pathology
- (2014) Sandra Blanco et al. CURRENT OPINION IN CELL BIOLOGY
- Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
- (2014) S. Blanco et al. EMBO JOURNAL
- Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity
- (2014) M. Y. Zhang et al. HAEMATOLOGICA
- Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA
- (2014) Lijuan Fu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview
- (2014) Marta Elena Hernández-Caballero et al. MOLECULAR BIOLOGY REPORTS
- Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
- (2014) Thomas M. Carlile et al. NATURE
- Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
- (2014) Chao Xu et al. Nature Chemical Biology
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- Inhibition of Human Dyskerin as a New Approach to Target Ribosome Biogenesis
- (2014) Laura Rocchi et al. PLoS One
- Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae
- (2014) Alexander F. Lovejoy et al. PLoS One
- G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments
- (2014) Pavel Ivanov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex
- (2014) Hiroki Takai et al. Cell Reports
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells
- (2014) Mayumi Okamoto et al. PLoS Genetics
- NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
- (2014) Metodi Dimitrov Metodiev et al. PLoS Genetics
- A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α
- (2013) Ulrike Begley et al. EMBO Molecular Medicine
- Slow growth and unstable ribosomal RNA lacking pseudouridine in mouse embryonic fibroblast cells expressing catalytically inactive dyskerin
- (2013) Bai-Wei Gu et al. FEBS LETTERS
- Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle
- (2013) Keiko Horiuchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation
- (2013) S. Hussain et al. MOLECULAR AND CELLULAR BIOLOGY
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- Identification of direct targets and modified bases of RNA cytosine methyltransferases
- (2013) Vahid Khoddami et al. NATURE BIOTECHNOLOGY
- A variant in FTO shows association with melanoma risk not due to BMI
- (2013) Mark M Iles et al. NATURE GENETICS
- Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively
- (2013) Sunny Sharma et al. NUCLEIC ACIDS RESEARCH
- Dyskerin depletion increases VEGF mRNA internal ribosome entry site-mediated translation
- (2013) Laura Rocchi et al. NUCLEIC ACIDS RESEARCH
- Long non-coding RNAs as targets for cytosine methylation
- (2013) Thomas Amort et al. RNA Biology
- NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs
- (2013) Shobbir Hussain et al. Cell Reports
- Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription
- (2013) Igor D Vilfan et al. JOURNAL OF NANOBIOTECHNOLOGY
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- ALY as a potential contributor to metastasis in human oral squamous cell carcinoma
- (2012) Yasuhiro Saito et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The Role of RNA Structure in Posttranscriptional Regulation of Gene Expression
- (2012) Elina Jacobs et al. Journal of Genetics and Genomics
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
- (2012) Francesca Tuorto et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
- (2012) Jeffrey E. Squires et al. NUCLEIC ACIDS RESEARCH
- Dyskerin Overexpression in Human Hepatocellular Carcinoma Is Associated with Advanced Clinical Stage and Poor Patient Prognosis
- (2012) Bei Liu et al. PLoS One
- The expression pattern of small nucleolar and small Cajal body-specific RNAs characterizes distinct molecular subtypes of multiple myeloma
- (2012) D Ronchetti et al. Blood Cancer Journal
- The birth of the Epitranscriptome: deciphering the function of RNA modifications
- (2012) Yogesh Saletore et al. GENOME BIOLOGY
- Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
- (2011) María S Domínguez-Sánchez et al. BMC CANCER
- Inhibition of 2-oxoglutarate dependent oxygenases
- (2011) Nathan R. Rose et al. CHEMICAL SOCIETY REVIEWS
- Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers
- (2011) Mayumi Okamoto et al. DNA AND CELL BIOLOGY
- Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
- (2011) B. P. Alter et al. HAEMATOLOGICA
- Landscape of TET2 mutations in acute myeloid leukemia
- (2011) S Weissmann et al. LEUKEMIA
- Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation
- (2011) Pavel Ivanov et al. MOLECULAR CELL
- rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells
- (2011) Karen Jack et al. MOLECULAR CELL
- Converting nonsense codons into sense codons by targeted pseudouridylation
- (2011) John Karijolich et al. NATURE
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
- (2011) Sandra Blanco et al. PLoS Genetics
- RNA nucleotide methylation
- (2011) Yuri Motorin et al. Wiley Interdisciplinary Reviews-RNA
- Loss of Function of the Tumor Suppressor DKC1 Perturbs p27 Translation Control and Contributes to Pituitary Tumorigenesis
- (2010) C. Bellodi et al. CANCER RESEARCH
- U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP
- (2010) Guowei Wu et al. EMBO JOURNAL
- Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita
- (2010) Cristian Bellodi et al. EMBO JOURNAL
- RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
- (2010) M. Schaefer et al. GENES & DEVELOPMENT
- Correlation of dyskerin expression with active proliferation independent of telomerase
- (2010) Faizan Alawi et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Genomic Aberrations in Lung Adenocarcinoma in Never Smokers
- (2010) Bastien Job et al. PLoS One
- A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress
- (2010) Clement T. Y. Chan et al. PLoS Genetics
- Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer
- (2009) Michaela Frye et al. CANCER LETTERS
- Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines
- (2009) M. Schaefer et al. CANCER RESEARCH
- The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability
- (2009) Shobbir Hussain et al. JOURNAL OF CELL BIOLOGY
- 5-methylcytosine in RNA: detection, enzymatic formation and biological functions
- (2009) Yuri Motorin et al. NUCLEIC ACIDS RESEARCH
- Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells
- (2009) Stéphane Belin et al. PLoS One
- Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing
- (2009) X.-h. Liang et al. RNA
- Real-time PCR quantification of human DKC1 expression in colorectal cancer
- (2008) Mimmo Turano et al. ACTA ONCOLOGICA
- Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications
- (2008) Paul F Agris EMBO REPORTS
- RNA Sequence and Two-dimensional Structure Features Required for Efficient Substrate Modification by theSaccharomyces cerevisiaeRNA:Ψ-Synthase Pus7p
- (2008) Alan Urban et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
- Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP
- (2008) C. Trahan et al. RNA
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