mTOR-dependent translation amplifies microglia priming in aging mice
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Title
mTOR-dependent translation amplifies microglia priming in aging mice
Authors
Keywords
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Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 131, Issue 1, Pages -
Publisher
American Society for Clinical Investigation
Online
2020-10-28
DOI
10.1172/jci132727
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Note: Only part of the references are listed.- Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells
- (2018) Hui Peng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TORC1 inhibition enhances immune function and reduces infections in the elderly
- (2018) Joan B. Mannick et al. Science Translational Medicine
- Therapeutic Opportunities in Eukaryotic Translation
- (2018) Jennifer Chu et al. Cold Spring Harbor Perspectives in Biology
- A transcriptomic atlas of aged human microglia
- (2018) Marta Olah et al. Nature Communications
- Innate immune memory in the brain shapes neurological disease hallmarks
- (2018) Ann-Christin Wendeln et al. NATURE
- Microglia in neurodegeneration
- (2018) Suzanne Hickman et al. NATURE NEUROSCIENCE
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- GENCODE reference annotation for the human and mouse genomes
- (2018) Adam Frankish et al. NUCLEIC ACIDS RESEARCH
- Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
- (2018) Sara Bachiller et al. Frontiers in Cellular Neuroscience
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
- (2017) Elvira Mass et al. NATURE
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
- (2017) Kathrin Leppek et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice
- (2017) Hong-Mei Zhang et al. Scientific Reports
- 4E-BP1, a multifactor regulated multifunctional protein
- (2016) Xiaoyu Qin et al. CELL CYCLE
- Microglial brain region−dependent diversity and selective regional sensitivities to aging
- (2016) Kathleen Grabert et al. NATURE NEUROSCIENCE
- Microglia Priming with Aging and Stress
- (2016) Anzela Niraula et al. NEUROPSYCHOPHARMACOLOGY
- Translational control by 5'-untranslated regions of eukaryotic mRNAs
- (2016) A. G. Hinnebusch et al. SCIENCE
- Differential Requirements for eIF4E Dose in Normal Development and Cancer
- (2015) Morgan L. Truitt et al. CELL
- The mammalian target of rapamycin modulates the immunoproteasome system in the heart
- (2015) Hong-Mei Zhang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- Targeting the translation machinery in cancer
- (2015) Mamatha Bhat et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1
- (2015) Naotaka Sekiyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade
- (2015) Richa Tyagi et al. Cell Reports
- Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
- (2015) Inge R Holtman et al. Acta Neuropathologica Communications
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Priming of microglia in a DNA-repair deficient model of accelerated aging
- (2014) Divya D.A. Raj et al. NEUROBIOLOGY OF AGING
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status
- (2013) Su Melser et al. Cell Metabolism
- Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period
- (2013) Takahito Tamai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin extends murine lifespan but has limited effects on aging
- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- The microglial sensome revealed by direct RNA sequencing
- (2013) Suzanne E Hickman et al. NATURE NEUROSCIENCE
- The GH/IGF-1 axis in ageing and longevity
- (2013) Riia K. Junnila et al. Nature Reviews Endocrinology
- Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice
- (2013) Marie Orre et al. NEUROBIOLOGY OF AGING
- Microglia during development and aging
- (2013) G. Jean Harry PHARMACOLOGY & THERAPEUTICS
- Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
- (2013) V. Hugh Perry et al. Seminars in Immunopathology
- The TSC-mTOR pathway regulates macrophage polarization
- (2013) Vanessa Byles et al. Nature Communications
- Software for Computing and Annotating Genomic Ranges
- (2013) Michael Lawrence et al. PLoS Computational Biology
- Regulation of Immune Responses by mTOR
- (2012) Jonathan D. Powell et al. Annual Review of Immunology
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis
- (2012) Bárbara González-Terán et al. JOURNAL OF CLINICAL INVESTIGATION
- Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex
- (2012) M. Hoshiko et al. JOURNAL OF NEUROSCIENCE
- Autism-related deficits via dysregulated eIF4E-dependent translational control
- (2012) Christos G. Gkogkas et al. NATURE
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
- (2012) Barbara Herdy et al. NATURE IMMUNOLOGY
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development
- (2011) Jia Zou et al. DEVELOPMENTAL CELL
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- (2011) Greg M Delgoffe et al. NATURE IMMUNOLOGY
- Physiology of Microglia
- (2011) Helmut Kettenmann et al. PHYSIOLOGICAL REVIEWS
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Rapamycin Activates Autophagy and Improves Myelination in Explant Cultures from Neuropathic Mice
- (2010) S. Rangaraju et al. JOURNAL OF NEUROSCIENCE
- Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction
- (2010) M. Shveygert et al. MOLECULAR AND CELLULAR BIOLOGY
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin
- (2009) S. Assouline et al. BLOOD
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
- (2009) Morris E Feldman et al. PLOS BIOLOGY
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- Translational control of the innate immune response through IRF-7
- (2008) Rodney Colina et al. NATURE
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- (2008) A. Y. Choo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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