Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

(2020) Yao Sun et al.   Journal of Neuroinflammation

Progression of Alzheimer's disease and effect of scFv‐h3D6 immunotherapy in the 3xTg‐AD mouse model: An in vivo longitudinal study using Magnetic Resonance Imaging and Spectroscopy

(2020) J. Güell‐Bosch et al.   NMR IN BIOMEDICINE

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

(2020) Matthias Arnold et al.   Nature Communications

Novel monoclonal antibody 3B8 specifically recognizes pyroglutamate-modified amyloid β 3-42 peptide in brain of AD patients and 3xTg-AD transgenic mice

(2020) Gonzalo Acero et al.   NEUROSCIENCE LETTERS

Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers

(2020) Julien Dufort-Gervais et al.   Scientific Reports

Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice

(2020) Alejandro R. Roda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dissociable cognitive impairments in two strains of transgenic Alzheimer’s disease mice revealed by a battery of object-based tests

(2019) Samantha D. Creighton et al.   Scientific Reports

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2019) Alina C. Stimmell et al.   Scientific Reports

Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases

(2019) Pedram Honarpisheh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sex-Gender Variable: Methodological Recommendations for Increasing Scientific Value of Clinical Studies

(2019) Franconi et al.   Cells

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden

(2019) Gisela Esquerda-Canals et al.   JOURNAL OF ALZHEIMERS DISEASE

Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb–Williams maze

(2019) Emre Fertan et al.   BEHAVIOURAL BRAIN RESEARCH

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Friend, Foe or Both? Immune Activity in Alzheimer’s Disease

(2019) Georgia R. Frost et al.   Frontiers in Aging Neuroscience

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

(2018) Rachel F. Buckley et al.   Alzheimers & Dementia

Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice

(2018) Laia Montoliu-Gaya et al.   BIOCHEMICAL PHARMACOLOGY

Sex and Gender Differences in the Brain Cholinergic System and in the Response to Therapy of Alzheimer Disease with Cholinesterase Inhibitors

(2018) Giacobini Ezio et al.   Current Alzheimer Research

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice

(2018) Minesh Kapadia et al.   JOURNAL OF ALZHEIMERS DISEASE

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Sexual dimorphism in predisposition to Alzheimer's disease

(2018) Daniel W. Fisher et al.   NEUROBIOLOGY OF AGING

Sex Differences in Hippocampal Memory and Kynurenic Acid Formation Following Acute Sleep Deprivation in Rats

(2018) Annalisa M. Baratta et al.   Scientific Reports

Immunotherapy to improve cognition and reduce pathological species in an Alzheimer’s disease mouse model

(2018) Krystal Herline et al.   Alzheimers Research & Therapy

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2018) Alice E. Kane et al.   Frontiers in Aging Neuroscience

Effect of Environmental Enrichment on the Immunoendocrine Aging of Male and Female Triple-Transgenic 3xTg-AD Mice for Alzheimer's Disease

(2018) Lorena Arranz et al.   JOURNAL OF ALZHEIMERS DISEASE

3xTg-AD Mice Exhibit an Activated Central Stress Axis During Early-Stage Pathology

(2018) Elaine K. Hebda-Bauer et al.   JOURNAL OF ALZHEIMERS DISEASE

The search for better animal models of Alzheimer’s disease

(2018) Anthony King   NATURE

Rodent models for Alzheimer disease

(2018) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer’s Disease

(2018) Jun-Ting Yang et al.   Neuroscience Bulletin

Sex differences in Alzheimer’s disease and common neuropathologies of aging

(2018) Shahram Oveisgharan et al.   ACTA NEUROPATHOLOGICA

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

Gender, GABAergic dysfunction and AD

(2018) A. Alia et al.   Aging-US

Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology

(2018) Roger N. Rosenberg et al.   Alzheimers Research & Therapy

Cognitive decline in Tg2576 mice shows sex-specific differences and correlates with cerebral amyloid-beta

(2018) Sebastian Schmid et al.   BEHAVIOURAL BRAIN RESEARCH

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy

(2017) Lucia Buccarello et al.   JOURNAL OF ALZHEIMERS DISEASE

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Sex differences in Alzheimer risk

(2017) Lisa Mosconi et al.   NEUROLOGY

Sex and gender differences in the treatment of Alzheimer’s disease: A systematic review of randomized controlled trials

(2017) Marco Canevelli et al.   PHARMACOLOGICAL RESEARCH

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

(2017) Syed F. Kazim et al.   Frontiers in Aging Neuroscience

To Group or Not to Group? Good Practice for Housing Male Laboratory Mice

(2017) Sarah Kappel et al.   Animals

Production of an anti-Aβ antibody fragment in Pichia pastoris and in vitro and in vivo validation of its therapeutic effect

(2017) Laia Montoliu-Gaya et al.   PLoS One

A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve

(2016) Matthew W. Granger et al.   JOURNAL OF ALZHEIMERS DISEASE

AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging

(2016) Lara Ordoñez-Gutierrez et al.   JOURNAL OF ALZHEIMERS DISEASE

Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice

(2016) Darrell Sawmiller et al.   JOURNAL OF NEUROIMMUNOLOGY

Age, APOE and sex: Triad of risk of Alzheimer’s disease

(2016) Brandalyn C. Riedel et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sex differences in Alzheimer's disease and other dementias

(2016) Carolyn M Mazure et al.   LANCET NEUROLOGY

Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease

(2016) Chiori Omori et al.   NUTRITIONAL NEUROSCIENCE

Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: Effects of neonatal handling stimulation and sexual dimorphism

(2015) T. Cañete et al.   BEHAVIOURAL BRAIN RESEARCH

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease

(2015) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

The problem of genotype and sex differences in life expectancy in transgenic AD mice

(2015) Eric A. Rae et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sex Dimorphism Profile of Alzheimer’s Disease-Type Pathologies in an APP/PS1 Mouse Model

(2015) Shu-Sheng Jiao et al.   NEUROTOXICITY RESEARCH

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Cognitive and emotional profiles of aged Alzheimer's disease (3×TgAD) mice: Effects of environmental enrichment and sexual dimorphism

(2014) Gloria Blázquez et al.   BEHAVIOURAL BRAIN RESEARCH

Olfactory delayed matching to sample performance in mice: Sex differences in the 5XFAD mouse model of Alzheimer's disease

(2014) Kyle M. Roddick et al.   BEHAVIOURAL BRAIN RESEARCH

The Mini Mental State Examination at the Time of Alzheimer's Disease and Related Disorders Diagnosis, According to Age, Education, Gender and Place of Residence: A Cross-Sectional Study among the French National Alzheimer Database

(2014) Christian Pradier et al.   PLoS One

Chronic stress as a risk factor for Alzheimer’s disease

(2014) Alberto Machado et al.   REVIEWS IN THE NEUROSCIENCES

Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences

(2014) Michelle Mielke et al.   Clinical Epidemiology

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

(2013) Leo Ungar et al.   Brain Imaging and Behavior

Sex and ESR1 genotype may influence the response to treatment with donepezil and rivastigmine in patients with Alzheimer's disease

(2013) Renato Scacchi et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice

(2013) Suhail Rasool et al.   JOURNAL OF NEUROCHEMISTRY

Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

(2013) Gisela Esquerda-Canals et al.   mAbs

Nonhuman Amyloid Oligomer Epitope Reduces Alzheimer’s-Like Neuropathology in 3xTg-AD Transgenic Mice

(2013) Suhail Rasool et al.   MOLECULAR NEUROBIOLOGY

Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice

(2012) Emily R. Rosario et al.   BRAIN RESEARCH

Sex-Dependent Alterations in Social Behaviour and Cortical Synaptic Activity Coincide at Different Ages in a Model of Alzheimer’s Disease

(2012) Cyril Bories et al.   PLoS One

Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways

(2010) Emily R. Rosario et al.   BRAIN RESEARCH

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

(2010) Roxanne Sterniczuk et al.   BRAIN RESEARCH

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Continuous and Cyclic Progesterone Differentially Interact with Estradiol in the Regulation of Alzheimer-Like Pathology in Female 3×Transgenic-Alzheimer’s Disease Mice

(2010) Jenna C. Carroll et al.   ENDOCRINOLOGY

Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice

(2010) Sylvia E. Perez et al.   NEUROBIOLOGY OF DISEASE

Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease?

(2010) Martin R Farlow   Alzheimers Research & Therapy

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

(2010) Latha Devi et al.   Molecular Brain

The Epigenetics of Sex Differences in the Brain

(2009) M. M. McCarthy et al.   JOURNAL OF NEUROSCIENCE

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Sex Differences in Autoimmune Disease from a Pathological Perspective

(2008) DeLisa Fairweather et al.   AMERICAN JOURNAL OF PATHOLOGY

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Selective Estrogen Receptor Modulators Differentially Regulate Alzheimer-Like Changes in Female 3xTg-AD Mice

(2008) Jenna C. Carroll et al.   ENDOCRINOLOGY

Gender-Specific Neuroimmunoendocrine Aging in a Triple-Transgenic 3×Tg-AD Mouse Model for Alzheimer’s Disease and Its Relation with Longevity

(2008) Lydia Giménez-Llort et al.   NEUROIMMUNOMODULATION

Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease

(2008) P.J. Pistell et al.   NEUROSCIENCE

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease

(2008) José J. Rodríguez et al.   PLoS One

Sexual dimorphism of humoral immunity with human vaccines

(2008) Ian Francis Cook   VACCINE