Protective Effect of Lupeol Against Lipopolysaccharide-Induced Neuroinflammation via the p38/c-Jun N-Terminal Kinase Pathway in the Adult Mouse Brain

Mitochondria and the Link Between Neuroinflammation and Neurodegeneration

(2017) Massimiliano Di Filippo et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex

(2014) Haroon Badshah et al.   NEUROCHEMISTRY INTERNATIONAL

Correction: mtDNA T8993G Mutation-Induced F1F0-ATP Synthase Defect Augments Mitochondrial Dysfunction Associated with hypoxia/reoxygenation: The Protective Role of Melatonin

(2014) Wen-Yi Huang et al.   PLoS One

Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain

(2014) S A Shah et al.   Cell Death & Disease

Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus

(2013) Haroon Badshah et al.   NEUROPEPTIDES

Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes

(2012) Archana Kumari et al.   FOOD AND CHEMICAL TOXICOLOGY

Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

(2012) James M. Brimson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

JNK signaling is the shared pathway linking neuroinflammation, blood–brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain

(2012) Lan-Wan Wang et al.   Journal of Neuroinflammation

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

(2012) Bijay Parajuli et al.   Journal of Neuroinflammation

Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade

(2012) Archana Kumari et al.   LIFE SCIENCES

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Growth Inhibition and Apoptosis Induced by Lupeol, a Dietary Triterpene, in Human Hepatocellular Carcinoma Cells

(2011) Yan He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

(2011) Bin Xing et al.   Molecular Neurodegeneration

Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia

(2011) Rajnish Gupta et al.   NATURAL PRODUCT RESEARCH

Insights Into Sepsis Therapeutic Design Based on the Apoptotic Death Pathway

(2010) Yuichi Hattori et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Beneficial health effects of lupeol triterpene: A review of preclinical studies

(2010) Hifzur Rahman Siddique et al.   LIFE SCIENCES

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris

(2009) Yan Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity

(2009) K. Papi Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroinflammation in Parkinson’s Disease

(2009) Jae-Kyung Lee et al.   Journal of Neuroimmune Pharmacology

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Harnessing Immune Alterations in Neurodegenerative Diseases

(2009) Maria Björkqvist et al.   NEURON

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY