Is RAGE still a therapeutic target for Alzheimer’s disease?

RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-β-Induced Cellular Perturbation?

(2017) Shi Du Yan et al.   JOURNAL OF ALZHEIMERS DISEASE

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Binding studies of truncated variants of the Aβ peptide to the V-domain of the RAGE receptor reveal Aβ residues responsible for binding

(2011) Emilia Gospodarska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

Solution Structure of the Soluble Receptor for Advanced Glycation End Products (sRAGE)

(2011) Zsuzsa Sárkány et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

(2011) Y. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Pattern Recognition with a Fibril-Specific Antibody Fragment Reveals the Surface Variability of Natural Amyloid Fibrils

(2011) Christian Haupt et al.   JOURNAL OF MOLECULAR BIOLOGY

S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling

(2011) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Advanced Glycation End Product Recognition by the Receptor for AGEs

(2011) Jing Xue et al.   STRUCTURE

RAGE: a single receptor fits multiple ligands

(2011) Günter Fritz   TRENDS IN BIOCHEMICAL SCIENCES

Advanced glycation endproducts: from precursors to RAGE: round and round we go

(2010) Ravichandran Ramasamy et al.   AMINO ACIDS

Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging

(2010) Shi Fang Yan et al.   BIOCHEMICAL PHARMACOLOGY

The RAGE Axis

(2010) Shi Fang Yan et al.   CIRCULATION RESEARCH

The 1.5 Å Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) Ectodomains Reveals Unique Features Determining Ligand Binding

(2010) HaJeung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Basis for Ligand Recognition and Activation of RAGE

(2010) Michael Koch et al.   STRUCTURE

Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene

(2009) Anastasia Z. Kalea et al.   FASEB JOURNAL

Tumor Necrosis Factor-α-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter

(2009) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts

(2009) Ravichandran Ramasamy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

(2009) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease

(2009) Sho-ichi Yamagishi et al.   PHARMACOLOGICAL RESEARCH

Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice

(2009) Seiichi Sakatani et al.   PLoS One

Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice

(2009) Li Ping Liu et al.   SYNAPSE

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

(2008) Angela Raucci et al.   FASEB JOURNAL

Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)

(2008) Jingjing Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Blockade of RAGE-Vd Prevents Amyloid-  Oligomer Neurotoxicity

(2008) E. Sturchler et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

V domain of RAGE interacts with AGEs on prostate carcinoma cells

(2008) Edith Uetz-von Allmen et al.   PROSTATE

Identification, classification, and expression of RAGE gene splice variants

(2007) Barry I. Hudson et al.   FASEB JOURNAL