Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles

(2014) Jian-Guo Li et al.   ANNALS OF NEUROLOGY

Retracted: Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion

(2014) Jie Qu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Repeated intra-hippocampal injection of beta-amyloid 25–35 induces a reproducible impairment of learning and memory: Considering caspase-3 and MAPKs activity

(2014) Rasoul Ghasemi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo

(2014) A Sclip et al.   Cell Death & Disease

Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

(2013) Sam Gandy et al.   Annual Review of Medicine

Inhibition of c-Jun N-terminal kinase prevents blood–brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage

(2012) Duo Chen et al.   ACTA NEUROCHIRURGICA

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer’s disease model

(2012) Yoon Ki Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

(2012) Moshiur Rahman et al.   BRAIN RESEARCH

Inhibition of Phosphorylation of JNK Suppresses Aβ-Induced ER Stress and Upregulates Prosurvival Mitochondrial Proteins in Rat Hippocampus

(2012) Parvin Yenki et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model

(2012) Jin Chu et al.   Journal of Neuroinflammation

RETRACTED: Multiple inflammatory pathways are involved in the development and progression of cognitive deficits in APPswe/PS1dE9 mice

(2012) Wei Zhang et al.   NEUROBIOLOGY OF AGING

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

c-Jun N-terminal Kinase Regulates Soluble Aβ Oligomers and Cognitive Impairment in AD Mouse Model

(2011) Alessandra Sclip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1–42) associated with decrease of apoptotic factors

(2010) Mahmoudreza Ramin et al.   BEHAVIOURAL BRAIN RESEARCH

Targeting Tau Protein in Alzheimerʼs Disease

(2010) Cheng-Xin Gong et al.   DRUGS & AGING

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

(2009) Vanja Vukic et al.   NEUROBIOLOGY OF DISEASE

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

The JNK pathway amplifies and drives subcellular changes in tau phosphorylation

(2009) J. Vogel et al.   NEUROPHARMACOLOGY

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

(2008) Chengyong Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING