The Crosstalk between FAK and Wnt Signaling Pathways in Cancer and Its Therapeutic Implication

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes

(2020) Taybor W. Parker et al.   Scientific Reports

FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials

(2020) Atish Mohanty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

(2020) Je-Hwan Lee et al.   Blood Advances

Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer

(2020) Jennifer R. Diamond et al.   BREAST CANCER RESEARCH AND TREATMENT

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

(2019) Jerry Harb et al.   Current Oncology Reports

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies

(2019) Maja J. A. de Jonge et al.   Targeted Oncology

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

(2019) Gabriel Mak et al.   BRITISH JOURNAL OF CANCER

PTK2 promotes cancer stem cell traits in hepatocellular carcinoma by activating Wnt/β-catenin signaling

(2019) Zhongyi Fan et al.   CANCER LETTERS

FAK and β‐Catenin Cooperate to Induce Hepatocellular Carcinoma

(2019) Shang Na et al.   HEPATOLOGY

Golgi Phosphoprotein 3 Promotes Malignant Phenotypes via FAK/Raf/MEK and Wnt/β-Catenin Signaling Pathways in Human Renal Cell Carcinoma

(2019) Meifang He et al.   Journal of Biomedical Nanotechnology

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

(2019) Jin Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FAK mediates BMP9-induced osteogenic differentiation via Wnt and MAPK signaling pathway in synovial mesenchymal stem cells

(2019) Weiwei Zheng et al.   Artificial Cells Nanomedicine and Biotechnology

The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

(2019) Betty Y. Tam et al.   CANCER LETTERS

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

(2019) Carlos J Diaz Osterman et al.   eLife

Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin

(2019) Wörthmüller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer

(2019) David E. Gerber et al.   LUNG CANCER

WNT Signaling in Tumors: The Way to Evade Drugs and Immunity

(2019) Elena Martin-Orozco et al.   Frontiers in Immunology

ITGBL1 promotes migration, invasion and predicts a poor prognosis in colorectal cancer

(2018) Xiao Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

FAK and BMP-9 synergistically trigger osteogenic differentiation and bone formation of adipose derived stem cells through enhancing Wnt-β-catenin signaling

(2018) Cheng Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

VE-cadherin promotes vasculogenic mimicry by modulating kaiso-dependent gene expression

(2018) Daniel Delgado-Bellido et al.   CELL DEATH AND DIFFERENTIATION

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

Dramatic dysbalancing of the Wnt pathway in breast cancers

(2018) Alexey Koval et al.   Scientific Reports

Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis

(2018) Hiroko Oshima et al.   FASEB JOURNAL

Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway

(2018) Janine Wörthmüller et al.   Oncotarget

FAK inhibitors in Cancer, a patent review

(2017) Peng-Cheng Lv et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells

(2017) Ding Wu et al.   JOURNAL OF BIOSCIENCES

Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer

(2017) Guangming Chen et al.   MOLECULAR CANCER THERAPEUTICS

Crosstalk and the evolvability of intracellular communication

(2017) Michael A. Rowland et al.   Nature Communications

Inhibition of FAK kinase activity preferentially targets cancer stem cells

(2017) Vihren N. Kolev et al.   Oncotarget

WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

(2017) Marcus M. Fischer et al.   Science Advances

New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway

(2017) Roberta Alfieri et al.   Frontiers in Oncology

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

(2016) J. C. Soria et al.   ANNALS OF ONCOLOGY

Extracellular matrix protein ITGBL1 promotes ovarian cancer cell migration and adhesion through Wnt/PCP signaling and FAK/SRC pathway

(2016) Li Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

A first-in-Asian phase 1 study to evaluate safety, pharmacokinetics and clinical activity of VS-6063, a focal adhesion kinase (FAK) inhibitor in Japanese patients with advanced solid tumors

(2016) Toshio Shimizu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer

(2016) Samira Jaeger et al.   CANCER RESEARCH

Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment

(2016) M. Roy-Luzarraga et al.   CLINICAL CANCER RESEARCH

The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

(2016) Giuseppe Bronte et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Two is better than one; toward a rational design of combinatorial therapy

(2016) Sheng-hong Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network

(2016) Jiajia Yang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling

(2016) Chunhui Sun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia

(2016) Pei-Jie Shi et al.   Journal of Hematology & Oncology

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination

(2016) Xiaoqiang Sun et al.   Oncotarget

ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGF  Signaling Pathway

(2015) X.-Q. Li et al.   CANCER RESEARCH

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

(2015) Suzanne F. Jones et al.   INVESTIGATIONAL NEW DRUGS

Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK–ERK–β-catenin pathway

(2015) Min Jung Ku et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Glycogen Synthase Kinase 3β Is Positively Regulated by Protein Kinase Cζ-Mediated Phosphorylation Induced by Wnt Agonists

(2015) Nydia Tejeda-Muñoz et al.   MOLECULAR AND CELLULAR BIOLOGY

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy

(2015) Kathryn E. Williams et al.   STEM CELLS

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β

(2015) Chenxi Gao et al.   eLife

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

(2015) Huai-Ching Tai et al.   Oncotarget

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

The potential of targeting Wnt/β-catenin in colon cancer

(2014) Ana Sebio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting FAK in human cancer: from finding to first clinical trials

(2014) Vita Golubovskaya   Frontiers in Bioscience-Landmark

FAK Is required for c-Met/β-catenin-driven hepatocarcinogenesis

(2014) Na Shang et al.   HEPATOLOGY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

(2014) I. M. Shapiro et al.   Science Translational Medicine

FAK and HAS Inhibition Synergistically Decrease Colon Cancer Cell Viability and Affect Expression of Critical Genes

(2013) Melissa Heffler et al.   Anti-Cancer Agents in Medicinal Chemistry

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

Target Inhibition Networks: Predicting Selective Combinations of Druggable Targets to Block Cancer Survival Pathways

(2013) Jing Tang et al.   PLoS Computational Biology

Focal Adhesion Kinase: A Key Mediator of Transforming Growth Factor Beta Signaling in Fibroblasts

(2013) Andrew Leask   Advances in Wound Care

A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation

(2012) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

FAK and WNT Signaling: The Meeting of Two Pathways in Cancer and Development

(2012) Yuri Fonar et al.   Anti-Cancer Agents in Medicinal Chemistry

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells

(2012) Rachel A. Ridgway et al.   CARCINOGENESIS

A Missing Link in Genotype-Directed Cancer Therapy

(2012) René Bernards   CELL

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Antimigratory Effects of the Methanol Extract fromMomordica charantiaon Human Lung Adenocarcinoma CL1 Cells

(2012) Hsue-Yin Hsu et al.   Evidence-based Complementary and Alternative Medicine

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal Adhesion Kinase Splice Variants Maintain Primitive Acute Myeloid Leukemia Cells Through Altered Wnt Signaling

(2012) Mathieu Despeaux et al.   STEM CELLS

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

Wnt Signaling in Skin Development, Homeostasis, and Disease

(2012) X. Lim et al.   Cold Spring Harbor Perspectives in Biology

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis

(2011) Jennifer P. Morton et al.   CELL CYCLE

Crosstalk in Cellular Signaling: Background Noise or the Real Thing?

(2011) Grégory Vert et al.   DEVELOPMENTAL CELL

Protein kinase C in Wnt signaling: Implications in cancer initiation and progression

(2011) Luis Bernardo Luna-Ulloa et al.   IUBMB LIFE

Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate

(2011) Yuri Fonar et al.   MOLECULAR BIOLOGY OF THE CELL

HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression

(2011) Y Li et al.   ONCOGENE

Apc Mutation Enhances PyMT-Induced Mammary Tumorigenesis

(2011) Jenifer R. Prosperi et al.   PLoS One

Blockade of the Wnt/β-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

(2011) Tae Hyung Kim et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer

(2010) Cha Kyong Yom et al.   BREAST CANCER RESEARCH AND TREATMENT

Hyperactivity and Enhanced Curiosity of Mice Expressing PKB/SGK-resistant Glycogen Synthase Kinase-3 (GSK-3)

(2010) Teresa F. Ackermann et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting Multiple Kinase Pathways: A Change In Paradigm

(2010) L. Gossage et al.   CLINICAL CANCER RESEARCH

A Wnt-ow of Opportunity: Targeting the Wnt/β-Catenin Pathway in Breast Cancer

(2010) Jenifer R. Prosperi et al.   CURRENT DRUG TARGETS

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Integration of the β-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2

(2009) Steve P. Crampton et al.   PLoS One

Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

(2009) A. J. Chien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

Mesothelioma Epidemiology, Carcinogenesis, and Pathogenesis

(2008) Haining Yang et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL