Article
Cell Biology
Yongkun Wei, Huiling Ma, Haiqing Zhou, Hanrong Yin, Jie Yang, Yongcai Song, Binhui Yang
Summary: Research indicates that overexpression of miR-424-5p in BMSCs-derived exosomes can regulate osteogenic differentiation of osteoblasts through the WIF1/Wnt/beta-catenin pathway, suggesting miR-424-5p as a potential new biomarker for the treatment of osteoporosis.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
Yibo Wang, Kai Hang, Li Ying, Jiaqi Wu, Xiaoyong Wu, Weijun Zhang, Lijun Li, Zhongxiang Wang, Jinwu Bai, Xiang Gao, Deting Xue, Zhijun Pan
Summary: Chaperone-mediated autophagy (CMA) protein LAMP2A plays a crucial role in regulating the adipo-osteogenesis process of MSCs. Co-expression analyses revealed the relationships between LAMP2A and other relevant genes. In vitro and in vivo experiments demonstrated that LAMP2A positively regulates mMSC osteogenesis, suppresses adipo-osteogenesis, and promotes fracture healing in a mouse model.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
Cuidi Xu, Hongli Shi, Xin Jiang, Yongqian Fan, Donghui Huang, Xinming Qi, Qun Cheng
Summary: ZEB1 is a key transcription factor in BMSC differentiation, playing a crucial role in maintaining bone health. Silencing ZEB1 can enhance osteogenesis and inhibit bone loss.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jianlian Xie, Jun Zhou, Jiliang Xia, Ying Zeng, Guo Huang, Weihong Zeng, Tingyu Fan, Lili Li, Xi Zeng, Qian Tao
Summary: PLCD1 is frequently downregulated in renal cell carcinoma (RCC) due to promoter CpG methylation. Restoring PLCD1 expression inhibits RCC cell viability and migration, causes cell cycle arrest and apoptosis. Additionally, PLCD1 suppresses WNT/beta-catenin and EGFR-FAK-ERK signaling and the EMT program in RCC cells.
CLINICAL EPIGENETICS
(2023)
Article
Pharmacology & Pharmacy
Lingli Ding, Song Gu, Bingyu Zhou, Min Wang, Yage Zhang, Siluo Wu, Hong Zou, Guoping Zhao, Zhao Gao, Liangliang Xu
Summary: Fractures have a negative impact on an individual's quality of life, but Ginsenoside Compound K (CK) found in Ginseng has shown potential for promoting bone regeneration and angiogenesis. This study found that CK can promote osteogenic differentiation of rat bone marrow mesenchymal stem cells and increase tube formation capacity in human umbilical vein endothelial cells. In a rat open femoral fracture model, CK was found to improve fracture repair and increase the formation of H type vessel in the fracture callus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jian Song, Nan Jiang, Xueqi Gan, Wei Zhi, Zhuoli Zhu
Summary: The study demonstrated that the local injection of argatroban can rescue bone loss in periodontal disease, while inducing osteogenic differentiation through activating the canonical Wnt signaling pathway. Therefore, argatroban has potential applications in promoting alveolar bone regeneration and remodeling based on BMSCs.
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Biochemistry & Molecular Biology
Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang, Minghai Wang
Summary: This study found that MFAP5 regulates osteogenesis in BMSCs through the Wnt/beta-catenin and AMPK signaling pathways, and may serve as a therapeutic target for patients with osteoporosis.
MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
German Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Summary: RNF43/ZNRF3 alterations contribute to liver disease and liver cancer by affecting differentiation and lipid metabolism of hepatocytes. The loss of these genes leads to steatohepatitis and an increase in unsaturated lipids. Deletion of Rnf43/Znrf3 results in defective hepatocyte regeneration and liver cancer, causing an imbalance between differentiation and proliferation. Interestingly, ZNRF3 mutant liver cancer patients have a poorer prognosis and exhibit altered hepatic lipid metabolism and steatohepatitis/NASH signatures.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Toxicology
Lu-lu Ren, Jia-yi Zhou, Shao-jie Liang, Xiu-qi Wang
Summary: This review discusses the impact of ETEC-induced diarrhea pathways and Wnt/β-catenin signaling pathway on the fate of intestinal stem cells, and highlights the current deficits in understanding the relationship between enterotoxins and intestinal epithelial cell activity.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Zhengmeng Yang, Lu Feng, Haixing Wang, Yucong Li, Jessica Hiu Tung Lo, Xiaoting Zhang, Xuan Lu, Yaofeng Wang, Sien Lin, Micky D. Tortorella, Gang Li
Summary: Osteoporosis is a common disease caused by an imbalance of bone formation and bone resorption. Sesamin, derived from the seed of Sesamum Indicum, has been shown to have dual-regulating functions on osteogenesis and osteoclastogenesis, potentially making it a therapeutic medication for osteoporosis treatment.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)