FAK inhibitors in Cancer, a patent review

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

(2017) Christina Schoenherr et al.   eLife

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency

(2016) Julie Farand et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

(2016) Gregory R. Ott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

FAK goes nuclear to control antitumor immunity—a new target in cancer immuno-therapy

(2016) Alan Serrels et al.   OncoImmunology

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Design, Synthesis, and Evaluation of Novel Imidazo[1,2-a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity

(2014) Pascal Dao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based discovery of cellular-active allosteric inhibitors of FAK

(2013) Naoki Tomita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scaffold mining of kinase hinge binders in crystal structure database

(2013) Li Xing et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The role of FAK in tumor metabolism and therapy

(2013) Jianliang Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Development of Focal Adhesion Kinase Inhibitors in Cancer Therapy

(2012) Wen Wee Ma   Anti-Cancer Agents in Medicinal Chemistry

Discovery and characterization of novel allosteric FAK inhibitors

(2012) Misa Iwatani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

(2012) Ssang-Taek Lim et al.   JOURNAL OF CELL BIOLOGY

Focal Adhesion Kinase as a Cancer Therapy Target

(2011) Vita M. Golubovskaya   Anti-Cancer Agents in Medicinal Chemistry

Focal adhesion kinase and tumour angiogenesis

(2011) Tanguy Lechertier et al.   JOURNAL OF PATHOLOGY

Focal adhesion kinase inhibitors are potent anti-angiogenic agents

(2011) Miguel A. Cabrita et al.   Molecular Oncology

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

(2009) Daniel P. Walker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Targeting focal adhesion kinase signaling in tumor growth and metastasis

(2009) Joerg Schwock et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

(2009) Alexander Schultze et al.   INVESTIGATIONAL NEW DRUGS

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

(2009) Seungil Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

(2008) Daniel P. Walker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH