Article
Biotechnology & Applied Microbiology
Ting Liu, Qianqian Ma, Wenjie Li, Yan Hu, Jun Yang, Qi Yao
Summary: Non-small cell lung cancer (NSCLC) cancer stem cells (CSCs) suppress reductive redox states and ROS levels in non-adherent spheres, while UBQLN1 protein level is positively correlated with patient's survival of lung adenocarcinoma.
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Biochemistry & Molecular Biology
Wasita Witayateeraporn, Hien Minh Nguyen, Duc Viet Ho, Hoai Thi Nguyen, Pithi Chanvorachote, Chanida Vinayanuwattikun, Varisa Pongrakhananon
Summary: This study identified the potential mechanism by which aspiletrein A (AA) induces apoptosis in lung cancer cells through the ROS/AMPK/mTOR axis, and it also demonstrated the inhibitory effect of AA on in vitro tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juhyeon Son, Okkeun Jung, Jong Heon Kim, Kyu Sang Park, Hee-Seok Kweon, Nhung Thi Nguyen, Yu Jin Lee, Hansol Cha, Yejin Lee, Quangdon Tran, Yoona Seo, Jongsun Park, Jungwon Choi, Heesun Cheong, Sang Yeol Lee
Summary: Mitochondrial methionyl-tRNA synthetase (MARS2) interacts with mitochondrial calcium uniporter (MCU) to stimulate mitochondrial Ca2+ influx. This interaction regulates cancer cell metabolism and inhibits epithelial-mesenchymal transition (EMT) through Ca2+-dependent signaling pathways. The expression of MARS2 is regulated by the ZEB1 transcription factor in response to Wnt signaling.
Article
Food Science & Technology
Moloya Gogoi, Jyoti L. Hati Boruah, Pranjit Kumar Bora, Deep Jyoti Das, Vanlalhruaii Famhawite, Anupam Biswas, Nusalu Puro, Jatin Kalita, Saikat Haldar, Rinku Baishya
Summary: The study demonstrated the inhibitory effect of Citrus macroptera peel extract on human non-small cell lung cancer cells through prooxidant induced apoptosis. CPEA was found to induce oxidative stress and mitochondrial membrane potential damage in A549 cells, resulting in cell death through apoptosis pathways.
Article
Cell Biology
Yang Li, Lan Yang
Summary: Cyclophilin A (cypA) is overexpressed in non-small-cell lung cancer (NSCLC) and is associated with hypoxia. It exerts its oncogenic effect by interacting with TXNIP.
Review
Oncology
Sarah Sayed Hassanein, Ahmed Lotfy Abdel-Mawgood, Sherif Abdelaziz Ibrahim
Summary: Lung cancer, divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), is mainly influenced by driver mutations and extracellular matrix (ECM) interactions with signaling molecules like epidermal growth factor receptor (EGFR). Understanding the crosstalk between EGFR and ECM in NSCLC can provide insights into disease pathobiology and therapeutic strategies, especially in developing resistance to EGFR inhibition.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Wu Chen, Danlei Yu, Shi-Yong Sun, Feng Li
Summary: This study developed nanoparticles to co-deliver osimertinib (OSI) and selumetinib (SEL) in order to effectively treat OSI-resistant non-small cell lung cancer. The nanoparticles, formed through a ROS-responsive PEG-SEL conjugate, demonstrated potential by inhibiting OSI-resistant tumors in vivo.
ACTA BIOMATERIALIA
(2021)
Article
Biology
Richard J. Lobb, Kekoolani S. Visan, Li-Ying Wu, Emma L. Norris, Marcus L. Hastie, Sarah Everitt, Ian A. Yang, Rayleen V. Bowman, Shankar Siva, Jill E. Larsen, Jeffrey J. Gorman, Michael MacManus, Antoine Leimgruber, Kwun M. Fong, Andreas Moller
Summary: Despite advancements in therapy, lung cancer remains a leading cause of cancer-related death globally. Non-small cell lung cancer (NSCLC) patients have a low five-year survival rate and current staging methods may not accurately predict outcomes. Epithelial-to-mesenchymal transition (EMT) and associated protein changes in extracellular vesicles may serve as prognostic markers in NSCLC patients, enabling personalized treatment decisions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Zhe Liu, Liang Ma, Yiming Sun, Wenying Yu, Xue Wang
Summary: The study demonstrated that the STAT3/ZEB1 axis is critical in gefitinib resistance in lung cancer, and a new potential therapeutic strategy targeting STAT3 has been identified with the inhibitor LL1. LL1 was shown to sensitize resistant cells to gefitinib by depleting STAT3 activity and blocking its signaling pathways, with little observed toxicity in animal models, indicating it could be a chemotherapeutic adjuvant for gefitinib resistance in NSCLC.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Leylah M. Drusbosky, Richa Dawar, Estelamari Rodriguez, Chukwuemeka Ikpeazu
Summary: The MET exon 14 skipping mutation is present in a small percentage of lung cancer patients, but targeted inhibitors like capmatinib and tepotinib show promising clinical activity with tolerable toxicity profiles. Ongoing research aims to overcome acquired resistance and enhance the effectiveness of these agents.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Boback Kaghazchi, In Hwa Um, Mustafa Elshani, Oliver J. Read, David J. Harrison
Summary: This study found that NQO1 protein expression is high in normal and tumor-adjacent tissue in non-small cell lung cancer (NSCLC), and it varies depending on the cell type. NQO1 is independent of NRF1 and NRF2 in tumors. Additionally, double-positive expression of NRF1 and NRF2 in cancer cells is associated with improved overall survival.
Article
Engineering, Chemical
El-Sayed Khafagy, Ahmed Al Saqr, Hadil Faris Alotaibi, Amr Selim Abu Lila
Summary: Rubus chingii ethanolic leaf extract (RcL-EtOH) exhibits significant anticancer potential against non-small cell lung cancer A549 cells by inducing cell apoptosis, regulating apoptotic gene expression, and showing minimal toxicity to normal cells. RcL-EtOH may serve as a promising therapeutic option for lung cancer management.
Article
Medicine, Research & Experimental
Jacek Pietrzak, Dagmara Szmajda-Krygier, Agnieszka Wosiak, Rafal Swiechowski, Katarzyna Michalska, Marek Mirowski, Marta Zebrowska-Nawrocka, Mariusz Lochowski, Ewa Balcerczak
Summary: The study examined the expression of membrane type matrix metalloproteinases genes in blood and tissue of NSCLC patients. The results showed that gene expression can be normalized after effective treatment, and lower expression of MMP15 in the blood was observed in patients with more advanced cancer. Additionally, higher expression of MMP14 and MMP15 in the tissue is associated with more advanced stage of disease development.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Okkeun Jung, Jongsung Lee, Yu Jin Lee, Jung-Mi Yun, Young-Jin Son, Jae Youl Cho, Chongsuk Ryou, Sang Yeol Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Food Science & Technology
Sang Yeol Lee, See-Hyoung Park, Mi Ok Kim, Inhwan Lim, Mingyeong Kang, Sae Woong Oh, Kwangseon Jung, Dong Gyu Jo, Il-Hoon Cho, Jongsung Lee
FOOD AND CHEMICAL TOXICOLOGY
(2016)
Article
Dermatology
Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee
EXPERIMENTAL DERMATOLOGY
(2017)
Article
Plant Sciences
Woo Seok Yang, Young-Su Yi, Donghyun Kim, Min Ho Kim, Jae Gwang Park, Eunji Kim, Sang Yeol Lee, Keejung Yoon, Jong-Hoon Kim, Junseong Park, Jae Youl Cho
JOURNAL OF GINSENG RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
See-Hyoung Park, Jae Youl Cho, Sae Woong Oh, Mingyeong Kang, Seung Eun Lee, Ju Ah Yoo, Kwangseon Jung, Jienny Lee, Sang Yeol Lee, Jongsung Lee
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Plant Sciences
Okkeun Jung, Sang Yeol Lee
JOURNAL OF GINSENG RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Juhyeon Son, Sang Yeol Lee
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Integrative & Complementary Medicine
Sang Yeol Lee
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Sang Yeol Lee
Summary: Matrix metalloproteinases (MMPs) play crucial roles in cancer metastasis and chronic inflammatory diseases, while ginsenosides have therapeutic potentials. Ginsenosides exhibit anti-metastatic and anti-inflammatory activities by suppressing MMPs through regulation of various signaling pathways.
Article
Biochemistry & Molecular Biology
Yu Jin Lee, Sang Yeol Lee
Summary: Maclurin, a natural compound extracted from white mulberry and purple mangosteen, demonstrates anticancer effects on human osteosarcoma cells by inducing prooxidative apoptosis and inhibiting cell migration. It modulates key signaling pathways related to cancer metastasis and shows potential as a candidate molecule for anti-osteosarcoma treatment.
Article
Biochemistry & Molecular Biology
Juhyeon Son, Okkeun Jung, Jong Heon Kim, Kyu Sang Park, Hee-Seok Kweon, Nhung Thi Nguyen, Yu Jin Lee, Hansol Cha, Yejin Lee, Quangdon Tran, Yoona Seo, Jongsun Park, Jungwon Choi, Heesun Cheong, Sang Yeol Lee
Summary: Mitochondrial methionyl-tRNA synthetase (MARS2) interacts with mitochondrial calcium uniporter (MCU) to stimulate mitochondrial Ca2+ influx. This interaction regulates cancer cell metabolism and inhibits epithelial-mesenchymal transition (EMT) through Ca2+-dependent signaling pathways. The expression of MARS2 is regulated by the ZEB1 transcription factor in response to Wnt signaling.
Article
Biochemistry & Molecular Biology
Juhyeon Son, Hansol Cha, Sungeun Lee, Yongwoong Bae, Chongsuk Ryou, Sang Yeol Lee
Summary: The phytochemical UNA was found to inhibit the proliferation, migration, and invasion abilities of MG63 cells by targeting the ERK and p38 signaling pathways as well as reducing MMP-2 expression. These findings suggest that UNA has the potential to be used as an anti-metastatic drug in the treatment of osteosarcoma.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Juhyeon Son, Sang Yeol Lee
Article
Biotechnology & Applied Microbiology
Muhammad Waqas, Huyen Trang Trinh, Sungeun Lee, Dae-Hwan Kim, Sang Yeol Lee, Kevin K. Choe, Chongsuk Ryou
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Soonchan Park, Jongsung Lee, Sang Yeol Lee
CELL BIOCHEMISTRY AND BIOPHYSICS
(2018)