Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53-miR-34a-c-Met Axis

(2013) C. W. Menges et al.   CANCER RESEARCH

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

(2013) M. Luo et al.   CANCER RESEARCH

Cancer Stem Cells: A Review of Potential Clinical Applications

(2012) Mark Podberezin et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells

(2012) Hiroto Yamazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus

(2012) Wei Li et al.   EMBO REPORTS

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Abstract A249: BI 853520, a potent and highly selective inhibitor of protein tyrosine kinase 2 (focal adhesion kinase), shows efficacy in multiple xenograft models of human cancer.

(2012) U. A. Hirt et al.   MOLECULAR CANCER THERAPEUTICS

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

Targeting the missing links for cancer therapy

(2011) Kornelia Polyak et al.   NATURE MEDICINE

Identification of cancer stem cell markers in human malignant mesothelioma cells

(2010) Farhana Ishrat Ghani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

Genomic Profiling Reveals Alternative Genetic Pathways of Meningioma Malignant Progression Dependent on the Underlying NF2 Status

(2010) S. Goutagny et al.   CLINICAL CANCER RESEARCH

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

(2009) M. Breuleux et al.   MOLECULAR CANCER THERAPEUTICS

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells

(2008) C. Flaiz et al.   GLIA

The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner

(2008) S. S. Houshmandi et al.   MOLECULAR AND CELLULAR BIOLOGY