Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis

Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium–glucose cotransporter 2 inhibitors

(2020) Milton Packer   EUROPEAN JOURNAL OF HEART FAILURE

Complications, morbidity and mortality of nonalcoholic fatty liver disease

(2020) Alessandro Mantovani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy

(2020) Youping Zhou et al.   Aging-US

Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study

(2020) Jun Hyung Kim et al.   Cardiovascular Diabetology

Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice

(2020) Aline David-Silva et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

A Systematic Review of Newer Antidiabetic Agents in the Treatment of Nonalcoholic Fatty Liver Disease

(2020) John A. Dougherty et al.   ANNALS OF PHARMACOTHERAPY

MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway

(2020) Zhiyuan Chen et al.   IMMUNOLOGY LETTERS

Metabolic liver disease in diabetes – From mechanisms to clinical trials

(2020) Bedair Dewidar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease

(2020) Kyung-Soo Kim et al.   Clinical and Molecular Hepatology

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

(2019) Yamei Han et al.   Nature Communications

Beyond glycemic control: New guidance on cardio-renal protection

(2019) Athanasios D. Anastasilakis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice

(2019) Damilola D. Adingupu et al.   Cardiovascular Diabetology

The liver as an endocrine organ - linking NAFLD and insulin resistance

(2019) Matthew J Watt et al.   ENDOCRINE REVIEWS

Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?

(2019) Niki Katsiki et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

(2019) Graziella Rodrigues et al.   Oxidative Medicine and Cellular Longevity

Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death

(2019) Ryo Shibusawa et al.   Scientific Reports

Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice

(2019) Caroline Daems et al.   Journal of Diabetes Research

Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet‐induced metabolic dysfunction and nonalcoholic fatty liver disease in mice

(2019) Hao Chiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial

(2019) Sabine Kahl et al.   DIABETES CARE

Empagliflozin improves primary haemodynamic parameters and attenuates the development of atherosclerosis in high fat diet fed APOE knockout mice

(2019) Georgios K. Dimitriadis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress

(2019) Marianna Holczer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats

(2019) Alana Aragón-Herrera et al.   BIOCHEMICAL PHARMACOLOGY

Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules

(2019) Kohshiro Hosokawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of newer antidiabetic drugs on nonalcoholic fatty liver and steatohepatitis: Think out of the box!

(2019) Golnaz Ranjbar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress

(2019) Tamiris Ingrid Petito-da-Silva et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells

(2018) Chenke Xu et al.   BIOCHEMICAL PHARMACOLOGY

Endoplasmic Reticulum Stress Related Molecular Mechanisms in Nonalcoholic Fatty Liver Disease (NAFLD)

(2018) Lifeng Wang et al.   CURRENT DRUG TARGETS

To die or not to die: death signaling in nonalcoholic fatty liver disease

(2018) Yuko Akazawa et al.   JOURNAL OF GASTROENTEROLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Pharmacotherapy of type 2 diabetes: An update

(2018) Jagriti Upadhyay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice

(2018) Νarjes Nasiri-Ansari et al.   Cardiovascular Diabetology

Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial

(2018) Naveed Sattar et al.   DIABETOLOGIA

Weight loss associated with sodium-glucose cotransporter-2 inhibition: a review of evidence and underlying mechanisms

(2018) P. C. Lee et al.   Obesity Reviews

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease

(2017) Seungwoo Lee et al.   Oncotarget

Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice

(2017) Koki Obara et al.   Oncotarget

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats

(2017) Sebastian Steven et al.   Redox Biology

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

(2017) Liang Xu et al.   EBioMedicine

The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE −/− mice fed a western diet

(2016) Ji Hye Han et al.   DIABETOLOGIA

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes

(2016) Teruo Jojima et al.   Diabetology & Metabolic Syndrome

The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice

(2016) Yasushi Honda et al.   PLoS One

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus

(2015) Shirong Qiang et al.   Diabetology & Metabolic Syndrome

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis

(2014) C.P. Li et al.   GENETICS AND MOLECULAR RESEARCH

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases

(2014) Beichu Guo et al.   Frontiers in Genetics

Mechanisms in endocrinology: Non-alcoholic fatty liver disease in common endocrine disorders

(2013) Jonathan M Hazlehurst et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Relation Among the Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio, Insulin Resistance, and Associated Cardio-Metabolic Risk Factors in Men and Women

(2012) Martin R. Salazar et al.   AMERICAN JOURNAL OF CARDIOLOGY

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Could glucose be a proaging factor?

(2008) Eva Kassi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Simvastatin activates Keap1/Nrf2 signaling in rat liver

(2008) Ioannis G. Habeos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE