Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis
出版年份 2021 全文链接
标题
Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 2, Pages 818
出版商
MDPI AG
发表日期
2021-01-16
DOI
10.3390/ijms22020818
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium–glucose cotransporter 2 inhibitors
- (2020) Milton Packer EUROPEAN JOURNAL OF HEART FAILURE
- Complications, morbidity and mortality of nonalcoholic fatty liver disease
- (2020) Alessandro Mantovani et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy
- (2020) Youping Zhou et al. Aging-US
- Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
- (2020) Jun Hyung Kim et al. Cardiovascular Diabetology
- Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice
- (2020) Aline David-Silva et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- A Systematic Review of Newer Antidiabetic Agents in the Treatment of Nonalcoholic Fatty Liver Disease
- (2020) John A. Dougherty et al. ANNALS OF PHARMACOTHERAPY
- MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway
- (2020) Zhiyuan Chen et al. IMMUNOLOGY LETTERS
- Metabolic liver disease in diabetes – From mechanisms to clinical trials
- (2020) Bedair Dewidar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
- (2020) Kyung-Soo Kim et al. Clinical and Molecular Hepatology
- The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection
- (2019) Hai Hu et al. Frontiers in Immunology
- Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
- (2019) Yamei Han et al. Nature Communications
- Beyond glycemic control: New guidance on cardio-renal protection
- (2019) Athanasios D. Anastasilakis et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice
- (2019) Damilola D. Adingupu et al. Cardiovascular Diabetology
- The liver as an endocrine organ - linking NAFLD and insulin resistance
- (2019) Matthew J Watt et al. ENDOCRINE REVIEWS
- Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
- (2019) Niki Katsiki et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model
- (2019) Graziella Rodrigues et al. Oxidative Medicine and Cellular Longevity
- Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
- (2019) Ryo Shibusawa et al. Scientific Reports
- Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice
- (2019) Caroline Daems et al. Journal of Diabetes Research
- Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet‐induced metabolic dysfunction and nonalcoholic fatty liver disease in mice
- (2019) Hao Chiang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial
- (2019) Sabine Kahl et al. DIABETES CARE
- Empagliflozin improves primary haemodynamic parameters and attenuates the development of atherosclerosis in high fat diet fed APOE knockout mice
- (2019) Georgios K. Dimitriadis et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress
- (2019) Marianna Holczer et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats
- (2019) Alana Aragón-Herrera et al. BIOCHEMICAL PHARMACOLOGY
- Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules
- (2019) Kohshiro Hosokawa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effects of newer antidiabetic drugs on nonalcoholic fatty liver and steatohepatitis: Think out of the box!
- (2019) Golnaz Ranjbar et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress
- (2019) Tamiris Ingrid Petito-da-Silva et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Canagliflozin exerts anti-inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells
- (2018) Chenke Xu et al. BIOCHEMICAL PHARMACOLOGY
- Endoplasmic Reticulum Stress Related Molecular Mechanisms in Nonalcoholic Fatty Liver Disease (NAFLD)
- (2018) Lifeng Wang et al. CURRENT DRUG TARGETS
- To die or not to die: death signaling in nonalcoholic fatty liver disease
- (2018) Yuko Akazawa et al. JOURNAL OF GASTROENTEROLOGY
- Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease
- (2018) Cynthia Lebeaupin et al. JOURNAL OF HEPATOLOGY
- Pharmacotherapy of type 2 diabetes: An update
- (2018) Jagriti Upadhyay et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice
- (2018) Νarjes Nasiri-Ansari et al. Cardiovascular Diabetology
- Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial
- (2018) Naveed Sattar et al. DIABETOLOGIA
- Weight loss associated with sodium-glucose cotransporter-2 inhibition: a review of evidence and underlying mechanisms
- (2018) P. C. Lee et al. Obesity Reviews
- Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery
- (2017) Shuling Song et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress
- (2017) Shuling Song et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease
- (2017) Seungwoo Lee et al. Oncotarget
- Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice
- (2017) Koki Obara et al. Oncotarget
- The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
- (2017) Sebastian Steven et al. Redox Biology
- SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
- (2017) Liang Xu et al. EBioMedicine
- The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE −/− mice fed a western diet
- (2016) Ji Hye Han et al. DIABETOLOGIA
- Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
- (2016) Manoela Mota et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes
- (2016) Teruo Jojima et al. Diabetology & Metabolic Syndrome
- The Selective SGLT2 Inhibitor Ipragliflozin Has a Therapeutic Effect on Nonalcoholic Steatohepatitis in Mice
- (2016) Yasushi Honda et al. PLoS One
- Cell death induced by endoplasmic reticulum stress
- (2015) Raffaella Iurlaro et al. FEBS Journal
- Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus
- (2015) Shirong Qiang et al. Diabetology & Metabolic Syndrome
- Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
- (2015) Robert Schierwagen et al. Scientific Reports
- Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis
- (2014) C.P. Li et al. GENETICS AND MOLECULAR RESEARCH
- Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
- (2014) Á González-Rodríguez et al. Cell Death & Disease
- Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases
- (2014) Beichu Guo et al. Frontiers in Genetics
- Mechanisms in endocrinology: Non-alcoholic fatty liver disease in common endocrine disorders
- (2013) Jonathan M Hazlehurst et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents
- (2013) Maximilian Hatting et al. HEPATOLOGY
- Relation Among the Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio, Insulin Resistance, and Associated Cardio-Metabolic Risk Factors in Men and Women
- (2012) Martin R. Salazar et al. AMERICAN JOURNAL OF CARDIOLOGY
- Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
- (2012) Jae-Seon So et al. Cell Metabolism
- Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
- (2012) Hyunsun Jo et al. HEPATOLOGY
- Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia
- (2010) Silvia Carloni et al. Autophagy
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- Could glucose be a proaging factor?
- (2008) Eva Kassi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Simvastatin activates Keap1/Nrf2 signaling in rat liver
- (2008) Ioannis G. Habeos et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury
- (2008) Silvia Carloni et al. NEUROBIOLOGY OF DISEASE
- Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
- (2008) A.-H. Lee et al. SCIENCE
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