Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
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Title
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
Authors
Keywords
Blood-brain barrier dysfunction, Clinical trials, Comorbidities, Excitotoxicity, Ischemic stroke, Neuroinflammation, Neuroprotection, Neuroprotective agents, Oxidative stress, Preclinical studies
Journal
EXPERIMENTAL NEUROLOGY
Volume 335, Issue -, Pages 113518
Publisher
Elsevier BV
Online
2020-11-02
DOI
10.1016/j.expneurol.2020.113518
References
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- Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population
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- Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2
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- MicroRNA-223 is neuroprotective by targeting glutamate receptors
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- Remote Ischemic Perconditioning Is Effective Alone and in Combination With Intravenous Tissue-Type Plasminogen Activator in Murine Model of Embolic Stroke
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- The 2012 Feinberg Lecture
- (2012) Jeffrey L. Saver STROKE
- Adapting clinical guidelines to take account of multimorbidity
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- Glibenclamide—10-h Treatment Window in a Clinically Relevant Model of Stroke
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- Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
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- Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury
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- Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats
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- miR-99 Family of MicroRNAs Suppresses the Expression of Prostate-Specific Antigen and Prostate Cancer Cell Proliferation
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- Forecasting the Future of Cardiovascular Disease in the United States
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- Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
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- Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Provides Neuroprotection in Mice Transient Focal Cerebral Ischemia
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- Multipotent Adult Progenitor Cells Prevent Macrophage-Mediated Axonal Dieback and Promote Regrowth after Spinal Cord Injury
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- Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies
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- Neuroprotection by Freezing Ischemic Penumbra Evolution Without Cerebral Blood Flow Augmentation With a Postsynaptic Density-95 Protein Inhibitor
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- The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia
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- Adropin Is a Novel Regulator of Endothelial Function
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- Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways
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- NR2B-NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death
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- High-Dose Intra-arterial Verapamil for the Treatment of Cerebral Vasospasm After Subarachnoid Hemorrhage
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- Vinpocetine inhibits NF- B-dependent inflammation via an IKK-dependent but PDE-independent mechanism
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- Glibenclamide Is Superior to Decompressive Craniectomy in a Rat Model of Malignant Stroke
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- Limb remote ischemic postconditioning protects against focal ischemia in rats
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- Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro
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- Edaravone (Radical Scavenger) versus Sodium Ozagrel (Antiplatelet Agent) in Acute Noncardioembolic Ischemic Stroke (EDO Trial)
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- Classification of Stroke Subtypes
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- Statins and Cardiovascular Diseases: From Cholesterol Lowering to Pleiotropy
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- Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity
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- Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor
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- Sulfonylurea receptors and mechanism of sulfonylurea action
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- Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway
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- Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke
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- Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress
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- The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons
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- NADPH Oxidase Isoforms and Anti-hypertensive Effects of Atorvastatin Demonstrated in Two Animal Models
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- Inflammatory mechanisms in ischemic stroke: therapeutic approaches
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- Incretin-based therapies for type 2 diabetes mellitus
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- Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
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- Expression Profile of MicroRNAs in Young Stroke Patients
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- GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
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- Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator
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- Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse
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- Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism
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- Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone
- (2008) Akira Hishida Clinical and Experimental Nephrology
- S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress
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- The Neuroprotection with Statin Therapy for Acute Recovery Trial (Neustart): An Adaptive Design Phase I Dose-Escalation Study of High-Dose Lovastatin in Acute Ischemic Stroke
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- Acute Treatment with Rosuvastatin Protects Insulin Resistant (C57BL/6J ob/ob) Mice against Transient Cerebral Ischemia
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- Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand
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- High-dose intraarterial verapamil in the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
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- Global burden of blood-pressure-related disease, 2001
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- Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
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- Neuroprotection for ischemic stroke: Past, present and future
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- MiR-15a and miR-16-1 cluster functions in human leukemia
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- Is It Time to Definitely Abandon Neuroprotection in Acute Ischemic Stroke?
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- Mechanical Thrombectomy for Acute Ischemic Stroke
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- Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat
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- Differential Neuroprotection and Risk for Bleeding From Activated Protein C With Varying Degrees of Anticoagulant Activity
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- Protective Effect of Delayed Treatment With Low-Dose Glibenclamide in Three Models of Ischemic Stroke
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- Edaravone, a Free Radical Scavenger, Inhibits MMP-9–Related Brain Hemorrhage in Rats Treated With Tissue Plasminogen Activator
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- Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage
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- Early disruptions of the blood–brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
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