L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia

(2018) Ying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-inflammatory effects of anisalcohol on lipopolysaccharide-stimulated BV2 microglia via selective modulation of microglia polarization and down-regulation of NF-κB p65 and JNK activation

(2018) Bin Xiang et al.   MOLECULAR IMMUNOLOGY

DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats

(2018) Qianqian Qi et al.   NEUROSCIENCE LETTERS

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2018) William J. Powers et al.   STROKE

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

(2017) Masato Kanazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

l-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia–Reperfusion Injury

(2017) Jing Xu et al.   NEUROCHEMICAL RESEARCH

Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1–Dependent M1 Microglial Polarization

(2017) Jue Wang et al.   STROKE

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

(2017) Zongjian Liu et al.   Frontiers in Aging Neuroscience

N -Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway

(2016) Ping Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK–Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats

(2016) Xiang-Ru Wen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease

(2016) Yu Zhang et al.   CNS Neuroscience & Therapeutics

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type

(2016) Daojing Li et al.   FASEB JOURNAL

Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling

(2016) Yating He et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury

(2016) Carlo Perego et al.   NEUROBIOLOGY OF DISEASE

Efficacy and safety comparison of DL-3-n-butylphthalide and Cerebrolysin: Effects on neurological and behavioral outcomes in acute ischemic stroke

(2016) LI-XIA XUE et al.   Experimental and Therapeutic Medicine

MicroRNA-181c Exacerbates Brain Injury in Acute Ischemic Stroke

(2016) Qingfeng Ma et al.   Aging and Disease

L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats

(2015) Li-Chao Yang et al.   CNS Neuroscience & Therapeutics

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

(2015) Jun Suenaga et al.   EXPERIMENTAL NEUROLOGY

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Treatment of acute stroke: an update

(2015) R. Mikulik et al.   JOURNAL OF INTERNAL MEDICINE

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Butylphthalide on the Brain Edema, Blood–Brain Barrier of Rats After Focal Cerebral Infarction and the Expression of Rho A

(2014) Jinyang Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia

(2014) Hanqin Wang et al.   Neural Regeneration Research

3-N-Butylphthalide (NBP) Attenuates the Amyloid-�-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway

(2013) Hong-Mei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DL-3-n-Butylphthalide, an Anti-Oxidant Agent, Prevents Neurological Deficits and Cerebral Injury Following Stroke per Functional Analysis, Magnetic Resonance Imaging and Histological Assessment

(2012) Lihong Zhang et al.   CURRENT NEUROVASCULAR RESEARCH

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics