Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

Four decades of ocular renin-angiotensin and kallikrein-kinin systems (1977–2017)

(2018) Rajko Igić   EXPERIMENTAL EYE RESEARCH

Tissue kallikrein protects against ischemic stroke by suppressing TLR4/NF-κB and activating Nrf2 signaling pathway in rats

(2017) Jiawei Yang et al.   Experimental and Therapeutic Medicine

Re-evaluate the Efficacy and Safety of Human Urinary Kallidinogenase (RESK): Protocol for an Open-Label, Single-Arm, Multicenter Phase IV Trial for the Treatment of Acute Ischemic Stroke in Chinese Patients

(2017) Jun Ni et al.   Translational Stroke Research

TGF-β1/Smad3 Signaling Pathway Suppresses Cell Apoptosis in Cerebral Ischemic Stroke Rats

(2017) Haiping Zhu et al.   MEDICAL SCIENCE MONITOR

Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose deprivation-induced injury through bradykinin B2 receptor-dependent regulation of autophagy induction

(2016) Yanping Liu et al.   JOURNAL OF NEUROCHEMISTRY

Human urine kininogenase attenuates balloon-induced intimal hyperplasia in rabbit carotid artery through transforming growth factor β1/Smad2/3 signaling pathway

(2016) Wenya Lan et al.   JOURNAL OF VASCULAR SURGERY

Exogenous kallikrein protects against diabetic nephropathy

(2016) Wenjuan Liu et al.   KIDNEY INTERNATIONAL

Tissue Kallikrein Prevents Restenosis After Stenting of Severe Atherosclerotic Stenosis of the Middle Cerebral Artery

(2016) Ruifeng Shi et al.   MEDICINE

Exogenous human urinary kallidinogenase increases cerebral blood flow in patients with acute ischemic stroke

(2016) Jing Miao et al.   Neurosciences

Effect of Urinary Kallidinogenase on Transforming Growth Factor-β1 and High-Sensitivity C-Reactive Protein Expression in Rat Focal Cerebral Ischemic Injury

(2016) Ting-Fang Dong et al.   MEDICAL SCIENCE MONITOR

Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

(2015) Jingwei Li et al.   Journal of Stroke & Cerebrovascular Diseases

Urinary kallidinogenase for the treatment of cerebral arterial stenosis

(2015) Qi Wan et al.   Drug Design Development and Therapy

Human Urinary Kallidinogenase Improves Outcome of Stroke Patients by Shortening Mean Transit Time of Perfusion Magnetic Resonance Imaging

(2015) Jingwei Li et al.   Journal of Stroke & Cerebrovascular Diseases

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

(2014) Egle Cekanaviciute et al.   GLIA

Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency

(2013) Louis Potier et al.   BIOLOGICAL CHEMISTRY

Tissue Kallikrein Preventing the Restenosis after Stenting of Symptomatic MCA Atherosclerotic Stenosis (KPRASS)

(2013) Wenya Lan et al.   International Journal of Stroke

Structure of plasma and tissue kallikreins

(2013) Monika Pathak et al.   THROMBOSIS AND HAEMOSTASIS

Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c

(2012) Jingjing Su et al.   CELLULAR SIGNALLING

Discovery and therapeutic potential of kinin receptor antagonists

(2012) Eric T Whalley et al.   Expert Opinion on Drug Discovery

Biology of the apelin-APJ axis in vascular formation

(2012) H. Kidoya et al.   JOURNAL OF BIOCHEMISTRY

Plasma tissue kallikrein level is negatively associated with incident and recurrent stroke: A multicenter case-control study in China

(2011) Qin Zhang et al.   ANNALS OF NEUROLOGY

Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway

(2011) Ling Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Tissue Kallikrein Promoted Activation of the Ipsilesional Sensorimotor Cortex after Acute Cerebral Infarction

(2011) Yi-Dong Wang et al.   EUROPEAN NEUROLOGY

Urine therapy through the centuries

(2011) Vincenzo Savica et al.   JOURNAL OF NEPHROLOGY

Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway

(2009) Ling Liu et al.   EXPERIMENTAL NEUROLOGY

Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1

(2009) Ling Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats

(2008) Li Ling et al.   BRAIN RESEARCH