Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse

Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse

(2016) Domenic A. LaRosa et al.   PEDIATRIC RESEARCH

Renal dysfunction in early adulthood following birth asphyxia in male spiny mice and its amelioration by maternal creatine supplementation during pregnancy

(2016) Stacey J. Ellery et al.   PEDIATRIC RESEARCH

Activated protein C promotes neuroprotection: mechanisms and translation to the clinic

(2016) John H. Griffin et al.   THROMBOSIS RESEARCH

Maternal Creatine Supplementation during Pregnancy Prevents Long-Term Changes in Diaphragm Muscle Structure and Function after Birth Asphyxia

(2016) Domenic A. LaRosa et al.   PLoS One

Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo

(2015) H. O. Eliwan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

(2014) Patrick Lyden et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Vitamin C Prevents Intrauterine Programming of in vivo Cardiovascular Dysfunction in the Rat

(2013) Andrew D. Kane et al.   CIRCULATION JOURNAL

Activated protein C accelerates venous thrombus resolution through heme oxygenase-1 induction

(2013) J. Gabre et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Apoptosis-related proteins are potential markers of neonatal hypoxic–ischemic encephalopathy (HIE) injury

(2013) Macarena Hernández-Jiménez et al.   NEUROSCIENCE LETTERS

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

STAT3-Mediated astrogliosis protects myelin development in neonatal brain injury

(2012) Hiroko Nobuta et al.   ANNALS OF NEUROLOGY

Neonatal encephalopathy: An inadequate term for hypoxic-ischemic encephalopathy

(2012) Joseph J. Volpe   ANNALS OF NEUROLOGY

Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke

(2012) Patricia D. Williams et al.   CURRENT PHARMACEUTICAL DESIGN

Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

(2012) Stacey J. Ellery et al.   PEDIATRIC RESEARCH

Developmental Programming of Cardiovascular Dysfunction by Prenatal Hypoxia and Oxidative Stress

(2012) Dino A. Giussani et al.   PLoS One

A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia

(2011) Z. Ireland et al.   NEUROSCIENCE

Cytoprotective protein C pathways and implications for stroke and neurological disorders

(2011) Berislav V. Zlokovic et al.   TRENDS IN NEUROSCIENCES

Antioxidant Treatment Alters Peripheral Vascular Dysfunction Induced by Postnatal Glucocorticoid Therapy in Rats

(2010) Emilio A. Herrera et al.   PLoS One

Neuroprotective Properties of Melatonin in a Model of Birth Asphyxia in the Spiny Mouse (Acomys cahirinus)

(2009) Lisa C. Hutton et al.   DEVELOPMENTAL NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Effects of activated protein C on neonatal hypoxic ischemic brain injury

(2008) Didem Cemile Yesilirmak et al.   BRAIN RESEARCH

Differential Neuroprotection and Risk for Bleeding From Activated Protein C With Varying Degrees of Anticoagulant Activity

(2008) Yaoming Wang et al.   STROKE

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL