Neuroprotective Mechanisms of Glucagon-like Peptide-1-based Therapies in Ischaemic Stroke: A Systematic Review based on Pre-Clinical Studies

The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

(2016) Ping-Chia Li et al.   BMC NEUROSCIENCE

Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor

(2016) V. Darsalia et al.   DIABETES OBESITY & METABOLISM

Neuroprotective Effects of rhGLP-1 in Diabetic Rats with Cerebral Ischemia/Reperfusion Injury

(2016) Daoli Jiang et al.   DRUG DEVELOPMENT RESEARCH

A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat

(2016) Ling Han et al.   NEUROREPORT

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

(2016) Takuma Kuroki et al.   STROKE

An Orally Active Allosteric GLP-1 Receptor Agonist Is Neuroprotective in Cellular and Rodent Models of Stroke

(2016) Huinan Zhang et al.   PLoS One

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

(2016) Huili Zhu et al.   Scientific Reports

Intranasal Delivery of Exendin-4 Confers Neuroprotective Effect Against Cerebral Ischemia in Mice

(2015) Huinan Zhang et al.   AAPS Journal

Protective effect of rhGLP-1 (7–36) on brain ischemia/reperfusion damage in diabetic rats

(2015) Libo Zhao et al.   BRAIN RESEARCH

DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

(2015) MingJie Ma et al.   Cardiovascular Diabetology

Pro-GLP-1, a Pro-drug of GLP-1, is neuroprotective in cerebral ischemia

(2015) Huinan Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Exendin-4-Loaded PLGA Microspheres Relieve Cerebral Ischemia/Reperfusion Injury and Neurologic Deficits through Long-Lasting Bioactivity-Mediated Phosphorylated Akt/eNOS Signaling in Rats

(2015) Chiang-Ting Chien et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glucagon-Like Peptide-1 Strengthens the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells Under Basal and Hyperglycemia Conditions

(2015) Shuji Fukuda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: Implication of the oxidative–inflammatory–apoptotic pathway

(2015) Ayman E. El-Sahar et al.   LIFE SCIENCES

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

(2015) Jennifer B. Green et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome

(2015) Marc A. Pfeffer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway

(2015) Yu Jia et al.   PHARMACOLOGICAL RESEARCH

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotective and anti-apoptotic effects of liraglutide in the rat brain following focal cerebral ischemia

(2014) S. Briyal et al.   NEUROSCIENCE

Exendin-4 Reduces Ischemic Brain Injury in Normal and Aged Type 2 Diabetic Mice and Promotes Microglial M2 Polarization

(2014) Vladimer Darsalia et al.   PLoS One

Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice

(2014) Vladimer Darsalia et al.   REGULATORY PEPTIDES

Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice

(2013) Dong Yang et al.   BRAIN RESEARCH

Neuroprotective Effects of Liraglutide for Stroke Model of Rats

(2013) Kenichiro Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Hyperglycemia in stroke and possible treatments

(2013) William A Li et al.   NEUROLOGICAL RESEARCH

Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes

(2013) William B. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

(2013) Benjamin M. Scirica et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride

(2012) V. Darsalia et al.   DIABETES

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic MaleApoE−/−Mice

(2012) Naim Panjwani et al.   ENDOCRINOLOGY

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia

(2012) Peter Röhnert et al.   Journal of Neuroinflammation

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

(2012) Joanna M Wardlaw et al.   LANCET

Role of the vascular endothelium and plaque in acute ischemic stroke

(2012) J. A. Madden   NEUROLOGY

Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells

(2011) Li Ding et al.   ACTA PHARMACOLOGICA SINICA

Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats

(2011) Seema Briyal et al.   BRAIN RESEARCH

Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats

(2011) Vladimer Darsalia et al.   CLINICAL SCIENCE

Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines

(2011) Carol Kilkenny et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Provides Neuroprotection in Mice Transient Focal Cerebral Ischemia

(2011) Shinichiro Teramoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia

(2011) Choong Hyun Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats

(2009) Holger Fuchs et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

(2009) Alison Hamilton et al.   NEUROREPORT

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA