Design principles of tissue organisation: How single cells coordinate across scales

Integration of luminal pressure and signalling in tissue self-organization

(2020) Chii J. Chan et al.   DEVELOPMENT

Phenotypic landscape of intestinal organoid regeneration

(2020) Ilya Lukonin et al.   NATURE

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Exploring single cells in space and time during tissue development, homeostasis and regeneration

(2019) Urs Mayr et al.   DEVELOPMENT

Communication codes in developmental signaling pathways

(2019) Pulin Li et al.   DEVELOPMENT

The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation

(2019) Jaline Gerardin et al.   Cell Systems

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

(2019) Cornelia Schwayer et al.   CELL

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo

(2019) Yuki Akieda et al.   Nature Communications

Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1

(2019) Aya Miyazaki et al.   Scientific Reports

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

(2019) Sapna Chhabra et al.   PLOS BIOLOGY

Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation

(2019) Allyson Quinn Ryan et al.   DEVELOPMENTAL CELL

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

(2018) Katharina F. Sonnen et al.   CELL

Chemical waves in cell and developmental biology

(2018) Victoria E. Deneke et al.   JOURNAL OF CELL BIOLOGY

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

(2018) Pulin Li et al.   SCIENCE

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Coordination of Cell Polarity, Mechanics and Fate in Tissue Self-organization

(2018) Esther Jeong Yoon Kim et al.   TRENDS IN CELL BIOLOGY

Symmetry Breaking in the Mammalian Embryo

(2018) Hui Ting Zhang et al.   Annual Review of Cell and Developmental Biology

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Multiplexed protein maps link subcellular organization to cellular states

(2018) Gabriele Gut et al.   SCIENCE

Programmable protein circuits in living cells

(2018) Xiaojing J. Gao et al.   SCIENCE

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Decoding of position in the developing neural tube from antiparallel morphogen gradients

(2017) Marcin Zagorski et al.   SCIENCE

Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns

(2016) Charisios D. Tsiairis et al.   CELL

Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo

(2016) Melanie D. White et al.   CELL

Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos

(2016) Victoria E. Deneke et al.   DEVELOPMENTAL CELL

Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

(2016) Eva Kutejova et al.   DEVELOPMENTAL CELL

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

(2016) Alexis B Webb et al.   eLife

Polarized Protein Transport and Lumen Formation During Epithelial Tissue Morphogenesis

(2015) Alex J. Blasky et al.   Annual Review of Cell and Developmental Biology

Organoids and the genetically encoded self-assembly of embryonic stem cells

(2015) David A. Turner et al.   BIOESSAYS

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

(2015) Giorgia Guglielmi et al.   DEVELOPMENTAL CELL

Inversion of Sonic hedgehog action on its canonical pathway by electrical activity

(2015) Yesser H. Belgacem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β

(2014) Lindsay B. Alcaraz et al.   JOURNAL OF CELL BIOLOGY

Spatial trigger waves: positive feedback gets you a long way

(2014) Lendert Gelens et al.   MOLECULAR BIOLOGY OF THE CELL

Luminal signalling links cell communication to tissue architecture during organogenesis

(2014) Sevi Durdu et al.   NATURE

The Role of Endocytosis during Morphogenetic Signaling

(2014) M. Gonzalez-Gaitan et al.   Cold Spring Harbor Perspectives in Biology

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Morphogen transport

(2013) P. Muller et al.   DEVELOPMENT

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

Directional tissue migration through a self-generated chemokine gradient

(2013) Erika Donà et al.   NATURE

Image-based transcriptomics in thousands of single human cells at single-molecule resolution

(2013) Nico Battich et al.   NATURE METHODS

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma

(2012) Joanna J. Phillips et al.   JOURNAL OF CLINICAL INVESTIGATION

The Onset of Collective Behavior in Social Amoebae

(2010) T. Gregor et al.   SCIENCE

Non-genetic heterogeneity of cells in development: more than just noise

(2009) S. Huang   DEVELOPMENT