Hypertonic saline mediates the NLRP3/IL‐1β signaling axis in microglia to alleviate ischemic blood‐brain barrier permeability by downregulating astrocyte‐derived VEGF in rats

Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes

(2019) Myoungsook Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke

(2019) Koutarou Nakamura et al.   JOURNAL OF BIOCHEMISTRY

Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca2+/CAMK II/ERK/NF-κB signaling pathway

(2019) Xiao-wei Ding et al.   ACTA PHARMACOLOGICA SINICA

NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

(2019) Pingping Ma et al.   Cell Communication and Signaling

Salt, inflammatory joint disease, and autoimmunity

(2018) Johanna Sigaux et al.   JOINT BONE SPINE

Hypertonic Saline Solution Reduces Microcirculatory Dysfunction and Inflammation in a Rat Model of Brain Death

(2018) Cristiano de Jesus Correia et al.   SHOCK

Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats

(2018) Jian Yin et al.   MEDICAL SCIENCE MONITOR

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

(2018) Raymond Wong et al.   BRAIN BEHAVIOR AND IMMUNITY

Hypertonic Saline for Increased Intracranial Pressure After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review

(2017) Christopher R. Pasarikovski et al.   World Neurosurgery

ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα

(2017) Dan Ting Kho et al.   PLoS One

Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes

(2016) Linqiang Huang et al.   BMC NEUROSCIENCE

Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats

(2015) Ming Fang et al.   BMC NEUROSCIENCE

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

Malignant MCA Infarction: Pathophysiology and Imaging for Early Diagnosis and Management Decisions

(2015) Wolf-Dieter Heiss   CEREBROVASCULAR DISEASES

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Hypertonic saline reduces cumulative and daily intracranial pressure burdens after severe traumatic brain injury

(2015) Halinder S. Mangat et al.   JOURNAL OF NEUROSURGERY

A Comparison of Equivolume, Equiosmolar Solutions of Hypertonic Saline and Mannitol for Brain Relaxation in Patients Undergoing Elective Intracranial Tumor Surgery

(2015) Pavel Dostal et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage

(2015) Zuraidah Abdullah et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

(2015) W. K. Eddie Ip et al.   Nature Communications

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation

(2014) Lin-Qiang Huang et al.   Journal of Neuroinflammation

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Vascular Endothelial Growth Factors Enhance the Permeability of the Mouse Blood-brain Barrier

(2014) Shize Jiang et al.   PLoS One

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Hyperosmolarity Attenuates TNF-α–Mediated Proinflammatory Activation of Human Pulmonary Microvascular Endothelial Cells

(2013) Anirban Banerjee et al.   SHOCK

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of the Beneficial Effect of Hypertonic Saline Solution in Acute Pancreatitis

(2010) Ana Maria Mendonça Coelho et al.   SHOCK

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of Ischemic Cerebral Edema: Role of Electroneutral Ion Transport

(2009) Kristopher T. Kahle et al.   PHYSIOLOGY

Hypertonic saline increases γδT cell-mediated killing of activated neutrophils

(2008) Mark I. Hirsh et al.   CRITICAL CARE MEDICINE