Oligodendrocytes in Development, Myelin Generation and Beyond

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

(2019) Jianqin Niu et al.   NATURE NEUROSCIENCE

The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones

(2019) Laura Fontenas et al.   Cell Reports

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

(2019) Breanne L. Harty et al.   Nature Communications

The Molecular Basis for Remyelination Failure in Multiple Sclerosis

(2019) Joel Gruchot et al.   Cells

Stem cell derived oligodendrocytes to study myelin diseases

(2019) Konstantina Chanoumidou et al.   GLIA

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

(2019) Leslie Kirby et al.   Nature Communications

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

(2019) David Orduz et al.   Nature Communications

From OPC to Oligodendrocyte: An Epigenetic Journey

(2019) Assia Tiane et al.   Cells

Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice

(2018) F. Cathomas et al.   GENES BRAIN AND BEHAVIOR

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

(2018) Ethan G. Hughes et al.   NATURE NEUROSCIENCE

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination

(2018) Dennis H. Lentferink et al.   Scientific Reports

Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors

(2018) Marie Dittmer et al.   Molecular Brain

An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

(2018) Jason J Early et al.   eLife

Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes

(2018) Rafael E. Flores-Obando et al.   Jove-Journal of Visualized Experiments

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

(2018) Juan Antonio García-León et al.   Stem Cell Reports

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

The adult oligodendrocyte can participate in remyelination

(2018) Ian D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

(2017) Bernhard Josef Rüther et al.   GLIA

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury

(2017) Erik van Tilborg et al.   GLIA

Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury

(2017) Peggy Assinck et al.   JOURNAL OF NEUROSCIENCE

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Ca2+ activity signatures of myelin sheath formation and growth in vivo

(2017) Marion Baraban et al.   NATURE NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation

(2017) Hirokazu Hashimoto et al.   NEUROCHEMISTRY INTERNATIONAL

White Matter Plasticity in the Adult Brain

(2017) Cassandra Sampaio-Baptista et al.   NEURON

Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors

(2017) Marc Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination

(2016) Abbe H. Crawford et al.   AMERICAN JOURNAL OF PATHOLOGY

White matter hyperintensities and imaging patterns of brain ageing in the general population

(2016) Mohamad Habes et al.   BRAIN

Inherited and acquired disorders of myelin: The underlying myelin pathology

(2016) Ian D. Duncan et al.   EXPERIMENTAL NEUROLOGY

Activation of oligodendroglial Stat3 is required for efficient remyelination

(2016) Andrew J. Steelman et al.   NEUROBIOLOGY OF DISEASE

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

(2016) H.-H. Tsai et al.   SCIENCE

Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression

(2016) Shingo Miyata et al.   Scientific Reports

Dynamics and Mechanisms of CNS Myelination

(2015) Kathryn K. Bercury et al.   DEVELOPMENTAL CELL

Olig1 Function Is Required for Oligodendrocyte Differentiation in the Mouse Brain

(2015) J. Dai et al.   JOURNAL OF NEUROSCIENCE

Chronic Oligodendrogenesis and Remyelination after Spinal Cord Injury in Mice and Rats

(2015) Z. C. Hesp et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Schwann Cell Myelination

(2015) James L. Salzer   Cold Spring Harbor Perspectives in Biology

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Altered whole-brain white matter networks in preclinical Alzheimer's disease

(2015) Florian Udo Fischer et al.   NeuroImage-Clinical

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination

(2015) Amélie Wegener et al.   BRAIN

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

A New Model of Cuprizone-Mediated Demyelination/Remyelination

(2014) Hilary H. Sachs et al.   ASN Neuro

Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

(2014) Nicolas Snaidero et al.   CELL

Tumor necrosis factor-α impairs oligodendroglial differentiation through a mitochondria-dependent process

(2014) M Bonora et al.   CELL DEATH AND DIFFERENTIATION

Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS

(2014) Q. Zhu et al.   DEVELOPMENT

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Expression of Proteolipid Protein Gene in Spinal Cord Stem Cells and Early Oligodendrocyte Progenitor Cells Is Dispensable for Normal Cell Migration and Myelination

(2014) D. E. Harlow et al.   JOURNAL OF NEUROSCIENCE

E2F1 Coregulates Cell Cycle Genes and Chromatin Components during the Transition of Oligodendrocyte Progenitors from Proliferation to Differentiation

(2014) L. Magri et al.   JOURNAL OF NEUROSCIENCE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation

(2014) L. Magri et al.   NEUROSCIENCE

Pelizaeus-Merzbacher disease: Cellular pathogenesis and pharmacologic therapy

(2014) Tomohiro Torii et al.   PEDIATRICS INTERNATIONAL

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Contact-Mediated Inhibition Between Oligodendrocyte Progenitor Cells and Motor Exit Point Glia Establishes the Spinal Cord Transition Zone

(2014) Cody J. Smith et al.   PLOS BIOLOGY

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles

(2013) Silvia Ravera et al.   BIOCHIMIE

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

Molecular evolution of myelin basic protein, an abundant structural myelin component

(2013) Schanila Nawaz et al.   GLIA

NG2 Cells in White Matter But Not Gray Matter Proliferate in Response to PDGF

(2013) R. A. Hill et al.   JOURNAL OF NEUROSCIENCE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

Regulation of conduction time along axons

(2013) A.H. Seidl   NEUROSCIENCE

Protocol to Isolate a Large Amount of Functional Oligodendrocyte Precursor Cells from the Cerebral Cortex of Adult Mice and Humans

(2013) Eva María Medina-Rodríguez et al.   PLoS One

Neuron-oligodendrocyte myelination co-culture derived from embryonic rat spinal cord and cerebral cortex

(2013) Yi Pang et al.   Brain and Behavior

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

(2012) Gwendolyn Behrendt et al.   GLIA

Isolation of cortical mouse oligodendrocyte precursor cells

(2012) Toros A. Dincman et al.   JOURNAL OF NEUROSCIENCE METHODS

The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration

(2012) Jason C. Dugas et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

A culture system to study oligodendrocyte myelination processes using engineered nanofibers

(2012) Seonok Lee et al.   NATURE METHODS

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

A putative functional role for oligodendrocytes in mood regulation

(2012) N Edgar et al.   Translational Psychiatry

Individual axons regulate the myelinating potential of single oligodendrocytes in vivo

(2011) R. G. Almeida et al.   DEVELOPMENT

Age-dependent fate and lineage restriction of single NG2 cells

(2011) X. Zhu et al.   DEVELOPMENT

CNS live imaging reveals a new mechanism of myelination: The liquid croissant model

(2011) Bettina Sobottka et al.   GLIA

Dorsally and Ventrally Derived Oligodendrocytes Have Similar Electrical Properties but Myelinate Preferred Tracts

(2011) R. B. Tripathi et al.   JOURNAL OF NEUROSCIENCE

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

The Proteolipid Protein Promoter Drives Expression outside of the Oligodendrocyte Lineage during Embryonic and Early Postnatal Development

(2011) John-Paul Michalski et al.   PLoS One

Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination

(2011) Mangala M. Soundarapandian et al.   Scientific Reports

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

(2010) Maya K. Desai et al.   AMERICAN JOURNAL OF PATHOLOGY

Mouse models for multiple sclerosis: Historical facts and future implications

(2010) Andrew L. Croxford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

(2010) Fanie Barnabé-Heider et al.   Cell Stem Cell

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

(2010) Shin H. Kang et al.   NEURON

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

(2010) C. D. Pozniak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes

(2010) Shinsuke Shibata et al.   Molecular Brain

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Live imaging of remyelination after antibody-mediated demyelination in an ex-vivo model for immune mediated CNS damage

(2009) Melanie D. Harrer et al.   EXPERIMENTAL NEUROLOGY

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

(2009) K. Arai et al.   JOURNAL OF NEUROSCIENCE

A Selective Glial Barrier at Motor Axon Exit Points Prevents Oligodendrocyte Migration from the Spinal Cord

(2009) S. Kucenas et al.   JOURNAL OF NEUROSCIENCE

Extensive remyelination of the CNS leads to functional recovery

(2009) I. D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat

(2009) F. Bandeira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte development and the onset of myelination in the human fetal brain

(2009) Igor Jakovcevski   Frontiers in Neuroanatomy

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease

(2008) B D Butts et al.   CELL DEATH AND DIFFERENTIATION

Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

(2008) Ashwin Woodhoo et al.   GLIA

The life, death, and replacement of oligodendrocytes in the adult CNS

(2008) Dana M. McTigue et al.   JOURNAL OF NEUROCHEMISTRY

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

(2008) Leanne E Rivers et al.   NATURE NEUROSCIENCE

Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone

(2008) D. Inta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES