Targeting pyroptosis to regulate ischemic stroke injury: Molecular mechanisms and preclinical evidences

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis

(2020) Yiyi Li et al.   EXPERIMENTAL CELL RESEARCH

NLRP6 expressed in astrocytes aggravates neurons injury after OGD/R through activating the inflammasome and inducing pyroptosis

(2020) Jinyan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma

(2020) Jian Zhuang et al.   BIOMEDICINE & PHARMACOTHERAPY

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

Caspase‐1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia

(2020) Jia Li et al.   CNS Neuroscience & Therapeutics

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

(2020) Qian Li et al.   EMBO Molecular Medicine

Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells

(2020) Xiaorui Yang et al.   Cell Death & Disease

Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice

(2020) Weijie Yan et al.   Neuroscience Bulletin

Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats

(2020) Feng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

(2020) Nathalia Moraes de Vasconcelos et al.   Cell Reports

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

(2019) Bozhi Ye et al.   Drug Design Development and Therapy

Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways

(2019) Shu Zhu et al.   NEUROCHEMISTRY INTERNATIONAL

BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats

(2019) Jianle Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interleukin-18 in Health and Disease

(2019) Koubun Yasuda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-1 Inhibition Attenuates Hyperoxia-Induced Lung and Brain Injury in Neonatal Mice

(2019) Fredrick Dapaah-Siakwan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

(2019) Congqing Wu et al.   IMMUNITY

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

(2019) Victor S. Tapia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes

(2019) Jianzhao Liao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats

(2019) Changchang Meng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Maigeng Zhou et al.   LANCET

Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved caspase-1 and IL-1β

(2019) Xiao-Qian Li et al.   NEUROPHARMACOLOGY

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

(2019) Lei Wang et al.   SCIENCE

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

(2019) Pengfei Xu et al.   Cell Death & Disease

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

(2019) Augusto V. Gonçalves et al.   PLoS Pathogens

The neuroprotection of progesterone against Aβ-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes

(2019) Yang Hong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gastrodin ameliorates microvascular reperfusion injury–induced pyroptosis by regulating the NLRP3/caspase-1 pathway

(2019) Wenjing Sun et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis

(2019) Pengpeng An et al.   LIFE SCIENCES

Inflammasome as a promising therapeutic target for cancer

(2019) Chaelin Lee et al.   LIFE SCIENCES

BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis

(2019) Yi Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

(2019) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of microglia mediated pyroptosis in neonatal hypoxic-ischemic brain damage

(2019) Yuan Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

(2019) Yang Long et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis

(2019) Junling Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats

(2019) Yan She et al.   JOURNAL OF ETHNOPHARMACOLOGY

Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

(2019) Mamunur Rashid Mahib et al.   MICROBIOLOGY AND IMMUNOLOGY

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Exosomes Mediate Hippocampal and Cortical Neuronal Injury Induced by Hepatic Ischemia-Reperfusion Injury through Activating Pyroptosis in Rats

(2019) Limei Zhang et al.   Oxidative Medicine and Cellular Longevity

Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases

(2019) Xiangna Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

(2019) Ji Liang et al.   EXPERIMENTAL NEUROLOGY

Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension

(2019) Min Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

(2018) Jonathon P. Audia et al.   BASIC RESEARCH IN CARDIOLOGY

Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats

(2018) Lubin Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis

(2018) Sherif Rashad et al.   BRAIN RESEARCH

Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ

(2018) Pingping Xia et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

NLRP6 Induces Pyroptosis by Activation of Caspase-1 in Gingival Fibroblasts

(2018) W. Liu et al.   JOURNAL OF DENTAL RESEARCH

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hispidulin Protects Against Focal Cerebral Ischemia Reperfusion Injury in Rats

(2018) Pengpeng An et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia

(2018) Schuichi Koizumi et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

(2018) Jie Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition

(2018) Zhonghua Liu et al.   STRUCTURE

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy

(2018) Yam Nath Paudel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

(2018) Joseph Flores et al.   Nature Communications

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

(2018) Qun Fu et al.   INFLAMMATION

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

(2018) Yunxia Fan et al.   Frontiers in Cellular Neuroscience

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

(2018) Claudia Semino et al.   Cell Death & Disease

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

(2018) Jaye M. Platnich et al.   Cell Reports

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

(2017) Revathy Guruswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function

(2017) Neil R. Sims et al.   NEUROCHEMISTRY INTERNATIONAL

Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment

(2017) M S Nandhu et al.   ONCOGENE

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

NLRP6 Inflammasome Ameliorates Brain Injury after Intracerebral Hemorrhage

(2017) Peng-Fei Wang et al.   Frontiers in Cellular Neuroscience

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

(2017) Danielle P. A. Mascarenhas et al.   PLoS Pathogens

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation

(2017) Andrea C. Lei-Leston et al.   Frontiers in Immunology

Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release

(2016) Nicolas J. Pillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

(2016) Adeeb Derakhshan et al.   CLINICAL CANCER RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Reactive astrocytes and therapeutic potential in focal ischemic stroke

(2016) Gourav Roy Choudhury et al.   NEUROBIOLOGY OF DISEASE

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway

(2016) Qiu-Ru Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment

(2015) Samira Goldar et al.   Asian Pacific Journal of Cancer Prevention

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

(2015) V Kaushal et al.   CELL DEATH AND DIFFERENTIATION

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

(2015) Jieling Yang et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanisms of unconventional secretion of IL-1 family cytokines

(2015) Mercedes Monteleone et al.   CYTOKINE

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

(2015) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting the Inflammasome: A Chemical Perspective

(2015) Alex G. Baldwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency

(2015) Isabell Lebkuechner et al.   JOURNAL OF NEUROCHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death

(2015) Daniela Rossi   PROGRESS IN NEUROBIOLOGY

Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

(2015) Qasim Alhadidi et al.   Translational Stroke Research

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF- -Induced Foxp3 Expression

(2014) S. Ikeda et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Leukocyte Invasion of the Brain After Experimental Intracerebral Hemorrhage in Mice

(2014) Eva Mracsko et al.   STROKE

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

(2013) Qian Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP

(2012) Kuo-Chieh Liao et al.   INFECTION AND IMMUNITY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

The Double-Stranded RNA Analogue Polyinosinic-Polycytidylic Acid Induces Keratinocyte Pyroptosis and Release of IL-36γ

(2012) Li-Hua Lian et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Microglia

(2008) Denis Soulet et al.   CURRENT BIOLOGY

β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes

(2008) Melanie J. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS