The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Redefining the ancestral origins of the interleukin-1 superfamily

(2018) Jack Rivers-Auty et al.   Nature Communications

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

(2018) Danielle M. Clancy et al.   Cell Reports

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

(2018) Tessa Swanton et al.   SLAS Discovery

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

(2018) Jack P. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses

(2018) Elena Redondo-Castro et al.   Scientific Reports

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

(2018) Claudia Semino et al.   Cell Death & Disease

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β

(2017) David Brough et al.   JOURNAL OF CELL SCIENCE

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

(2015) Xiaolong Xu et al.   MEDIATORS OF INFLAMMATION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions

(2015) Monique Stoffels et al.   Frontiers in Immunology

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Real-time single-cell imaging of protein secretion

(2014) Yoshitaka Shirasaki et al.   Scientific Reports

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL