Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice

NLRP3: A promising therapeutic target for autoimmune diseases

(2018) Hui-Hui Shen et al.   AUTOIMMUNITY REVIEWS

The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways

(2018) Danlu Jiang et al.   CANCER LETTERS

Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats

(2018) Hong-Guang Ding et al.   Journal of Neuroinflammation

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo

(2018) Yingjie Qi et al.   NEUROBIOLOGY OF DISEASE

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

Post-Operative Cognitive Dysfunction: An exploration of the inflammatory hypothesis and novel therapies

(2018) David R. Skvarc et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Anesthetic Immunomodulation of the Neuroinflammation in Postoperative Cognitive Dysfunction

(2017) Matthew Umholtz et al.   IMMUNOLOGICAL INVESTIGATIONS

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

(2017) Zhirong Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats

(2017) Jing Wu et al.   Frontiers in Cellular Neuroscience

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

(2017) Weiqiang Chen et al.   Nature Microbiology

BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice

(2016) Jing Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Hypothermia-induced ischemic tolerance is associated with Drp1 inhibition in cerebral ischemia-reperfusion injury of mice

(2016) Yingying Tang et al.   BRAIN RESEARCH

Pore formation by GSDMD is the effector mechanism of pyroptosis

(2016) Moritz M Gaidt et al.   EMBO JOURNAL

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective Neuronal Vulnerability of Human Hippocampal CA1 Neurons: Lesion Evolution, Temporal Course, and Pattern of Hippocampal Damage in Diffusion-Weighted MR Imaging

(2015) Thorsten Bartsch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

The hippocampus in aging and disease: From plasticity to vulnerability

(2015) T. Bartsch et al.   NEUROSCIENCE

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice

(2015) Jing Wu et al.   PLoS One

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning

(2014) Iris B. Hovens et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

(2014) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

(2014) M-S Tan et al.   Cell Death & Disease

Resveratrol Pretreatment Attenuates the Isoflurane-Induced Cognitive Impairment Through its Anti-Inflammation and -Apoptosis Actions in Aged Mice

(2013) Xiao-min Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE