Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
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Title
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
Authors
Keywords
Legionella pneumophila, Macrophages, Inflammasomes, Flagellin, Cell death, Intracellular pathogens, Bacterial diseases, Luminescence
Journal
PLoS Pathogens
Volume 15, Issue 6, Pages e1007886
Publisher
Public Library of Science (PLoS)
Online
2019-06-29
DOI
10.1371/journal.ppat.1007886
References
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Note: Only part of the references are listed.- Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
- (2018) Joseph Sarhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8
- (2017) Isabella Rauch et al. IMMUNITY
- The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion
- (2017) Jeannette L. Tenthorey et al. SCIENCE
- Gasdermins: Effectors of Pyroptosis
- (2017) Stephen B. Kovacs et al. TRENDS IN CELL BIOLOGY
- The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
- (2017) Katharina S. Schneider et al. Cell Reports
- Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome
- (2017) Danielle P. A. Mascarenhas et al. PLoS Pathogens
- Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis
- (2016) Ine Jorgensen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by FlagellatedLegionellaSpecies in Mouse Macrophages and In Vivo
- (2015) Daiane M. Cerqueira et al. JOURNAL OF IMMUNOLOGY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1 Production
- (2013) S. M. Man et al. JOURNAL OF IMMUNOLOGY
- Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila
- (2013) C. L. Case et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-11 Protects Against Bacteria That Escape the Vacuole
- (2013) Y. Aachoui et al. SCIENCE
- Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
- (2013) Cierra N. Casson et al. PLoS Pathogens
- Recognition of Bacteria by Inflammasomes
- (2012) Jakob von Moltke et al. Annual Review of Immunology
- Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization
- (2012) Anwari Akhter et al. IMMUNITY
- Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
- (2012) Jakob von Moltke et al. NATURE
- Activation of NLRC4 by Flagellated Bacteria Triggers Caspase-1-Dependent and -Independent Responses To Restrict Legionella pneumophila Replication in Macrophages and In Vivo
- (2011) M. S. F. Pereira et al. JOURNAL OF IMMUNOLOGY
- The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
- (2011) Yue Zhao et al. NATURE
- Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
- (2011) Andrew Oberst et al. NATURE
- Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
- (2011) Eric M. Kofoed et al. NATURE
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- Asc-Dependent and Independent Mechanisms Contribute to Restriction of Legionella Pneumophila Infection in Murine Macrophages
- (2011) Dalia H. A. Abdelaziz et al. Frontiers in Microbiology
- The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis
- (2011) Marcelo S. F. Pereira et al. Frontiers in Microbiology
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
- Pore Formation Triggered by Legionella spp. Is an Nlrc4 Inflammasome-Dependent Host Cell Response That Precedes Pyroptosis
- (2010) T. N. Silveira et al. INFECTION AND IMMUNITY
- Inflammatory Stimuli Regulate Caspase Substrate Profiles
- (2010) Nicholas J. Agard et al. MOLECULAR & CELLULAR PROTEOMICS
- A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells
- (2010) Fernanda M. Marim et al. PLoS One
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
- (2009) Sudan He et al. CELL
- Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection
- (2009) Anwari Akhter et al. PLoS Pathogens
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes
- (2008) Mohamed Lamkanfi et al. MOLECULAR & CELLULAR PROTEOMICS
- Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
- (2008) Karla L Lightfield et al. NATURE IMMUNOLOGY
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