Article
Environmental Sciences
Xie Han, Yanling Tang, Yuanli Zhang, Jingjing Zhang, Zeyu Hu, Wanjing Xu, Shangzhi Xu, Qiang Niu
Summary: The study found that fluoride can induce developmental neurotoxicity by inhibiting lysosomal function through V-ATPase, leading to autophagic flux blockage and apoptosis. Therefore, V-ATPase may be a promising indicator of developmental fluoride neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Huajun Han, Laurie A. Davidson, Martha Hensel, Grace Yoon, Kerstin Landrock, Clinton Allred, Arul Jayaraman, Ivan Ivanov, Stephen H. Safe, Robert S. Chapkin
Summary: The study reveals the protective role of AhR signaling in genetically induced colon tumorigenesis at least by suppressing Wnt signaling and provides rationale for the AhR as a therapeutic target for cancer prevention and treatment.
MOLECULAR CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Biochemistry & Molecular Biology
Yanwei Lu, Xudong Li, Hongli Liu, Jun Xue, Zhen Zeng, Xiaorong Dong, Tao Zhang, Gang Wu, Kunyu Yang, Shuangbing Xu
Summary: LZTS2 is downregulated in HCC and associated with poor prognosis. It inhibits HCC tumorigenesis and metastasis by suppressing PI3K/AKT signaling. Furthermore, LZTS2 is targeted for degradation by E3 ligase and protein kinase, promoting HCC progression and metastasis.
Article
Multidisciplinary Sciences
Longfei Wang, Di Wu, Carol Robinson, Tian-Min Fu
Summary: This study identifies a new protein called mEAK-7 that interacts with V-ATPases and may regulate its function while also being involved in mTOR signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Aysenur Gok, Aynur Isik, Sinem Bakir, Sarp Uzun, Gunes Guner, Ozge Ozcan, Baris Cerci, Ilyas Onbasilar, Aytekin Akyol
Summary: This study examined the effects of reduced Bdnf levels in an Apc mutant intestinal/colonic tumor mouse model. The results showed that Bdnf mutant and Apc/Bdnf double mutant mice had a significant weight gain compared to controls. The small intestine polyp count decreased slightly in Apc/Bdnf double mutant mice, while the colon polyp count increased significantly.
Article
Biochemistry & Molecular Biology
Yuling Tang, Lei Dong, Chong Zhang, Xiubin Li, Rongyu Li, Huisang Lin, Yini Qi, Mingchuan Tang, Yanli Peng, Chuan Liu, Jian Zhou, Ning Hou, Wenjia Liu, Guan Yang, Xiao Yang, Yan Teng
Summary: PRMT5 deficiency in mouse gastric epithelium leads to spontaneous tumorigenesis in gastric antrum, with the development of intestinal-type gastric cancer; some Prmt5 mutant mice eventually progress to invasive gastric cancer; PRMT5 loss-induced gastric cancer demonstrates activation of the Wnt/??-Catenin signaling pathway, which is a key driver in gastric tumorigenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Article
Pathology
Sonja Chen, Sara Gallant, Michael J. Cunningham, Caroline D. Robson, Alanna J. Church, Antonio R. Perez-Atayde, Alyaa Al-Ibraheemi
Summary: This study describes 8 cases of sinonasal myxoma (SNM) and analyzes the clinical and biological differences compared to desmoid fibromatosis. The findings expand the understanding of SNM and highlight its differences from desmoid fibromatosis in histology, clinical characteristics, and genetics.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kibrom M. Alula, Yaritza Delgado-Deida, Dakota N. Jackson, K. Venuprasad, Arianne L. Theiss
Summary: PHB1 plays a role in inhibiting the Wnt/β-catenin pathway to influence the development of intestinal tumorigenesis by regulating AXIN1 expression and the beta-catenin destruction complex. Induction of nuclear PHB1 trafficking provides a novel therapeutic option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestinal tumorigenesis.
Article
Cell Biology
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei, Weiguo Hu
Summary: This study uncovers the activation of C5 complement within tumor cells, which affects colorectal tumorigenesis by regulating the stability of beta-catenin. The findings provide a potential target for tumor prevention and treatment.
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Review
Neurosciences
Maisa I. Alkailani, Mohamed Aittaleb, Fadel Tissir
Summary: Neurogenesis and tumorigenesis share common signaling molecules and pathways involved in cell proliferation, differentiation, migration, and death. Abnormalities in these molecular mechanisms can lead to tumor formation and progression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Biochemistry & Molecular Biology
Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, Jae-Il Park
Summary: PAF drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. Its depletion induces cell quiescence in lung adenocarcinoma cells and inhibits tumor growth, suggesting the PAF-DREAM axis as a potential therapeutic target in lung cancer.
Article
Engineering, Chemical
Dool-Ri Oh, Moon-Jong Kim, Eun-Jin Choi, Yujin Kim, Hak-Sung Lee, Donghyuck Bae, Chulyung Choi
Summary: The study found that p-coumaric acid from the water extract of Vaccinium bracteatum leaves protects against CORT-induced neurotoxicity by increasing CREB phosphorylation in neuronal cells.
Article
Dentistry, Oral Surgery & Medicine
Jee-Hye Choi, Moon-Jong Kim, Hong-Seop Kho
Summary: In patients with xerostomia, subjective perceptions of saliva amount and the experience of speaking difficulty significantly affect oral health-related quality of life (OHRQol).
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2021)
Article
Multidisciplinary Sciences
Moon-Jong Kim, Pil-Jong Kim, Hong-Gee Kim, Hong-Seop Kho
Summary: This study used a machine learning approach to predict responses to initial treatment and clonazepam therapy in patients with BMS, finding that aggravating factors and psychological distress were important for initial treatment while symptom intensity was crucial for clonazepam therapy. The prediction models showed accuracies of 67.6% and 67.4% for initial treatment and clonazepam therapy, respectively, demonstrating the clinical applicability of the results.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Kee-Beom Kim, Ashish Kabra, Dong-Wook Kim, Yongming Xue, Yuanjian Huang, Pei-Chi Hou, Yunpeng Zhou, Leilani J. Miranda, Jae-Il Park, Xiaobing Shi, Timothy P. Bender, John H. Bushweller, Kwon-Sik Park
Summary: EP300, an important transcription coactivator in proliferation and differentiation, is frequently mutated in various cancer types. This study found that EP300 mutants without acetyltransferase domain accelerate tumor development in small cell lung cancer (SCLC) mouse models, while complete EP300 knockout suppresses SCLC development and proliferation. The kinase inducible domain-interacting (KIX) domain of EP300, specifically its interaction with transcription factors including MYB, was identified as the determinant of protumorigenic activity. Inhibition of KIX-mediated interactions inhibits SCLC development and cell growth.
Article
Multidisciplinary Sciences
Biyun Zheng, Kyung-Pil Ko, Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park
Summary: This study developed a new esophageal organoid culture medium for culturing murine EOs and establishing an early ESCC model. The research laid the foundation for ESCC research and drug discovery by proposing a new formula for EO culture with minimum components and an organoid model mimicking ESCC initiation.
Review
Gastroenterology & Hepatology
Gengyi Zou, Jae-Il Park
Summary: The liver has a high recovery rate from acute injuries, but chronic liver disease can lead to adverse consequences such as fibrosis, cirrhosis, and liver cancer due to long-term hepatocyte loss. The Wnt signaling plays a crucial role in liver regeneration and tumorigenesis, making it an attractive target for liver disease and cancer treatment. However, blocking Wnt signaling can also cause adverse effects due to its important physiological functions. Recent studies have identified cancer-specific regulators of Wnt signaling, which have potential for liver cancer treatment. This review discusses the role of Wnt signaling in liver regeneration, precancerous lesions, and liver cancer, and summarizes the approaches and prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Oncology
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-ll Park, Yi Zheng, Kwon-Sik Park
Summary: This study characterizes the activity of the WNT pathway in small cell lung cancer (SCLC) and identifies the key role of the WNT5A-RHOA axis in SCLC progression. It provides potential targets for therapeutic interventions and biomarkers to improve patient treatment.
Letter
Oncology
Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien, Junjie Chen, Jae-Il Park
CANCER COMMUNICATIONS
(2023)
Review
Cell Biology
Woo-Jung Park, Moon Jong Kim
Summary: Aberrant activation of Wnt signaling is commonly observed in various cancers, but targeting this pathway for cancer treatment is challenging due to its pleiotropic role and complexity. However, alternative strategies based on new technologies provide new opportunities for clinically realizing Wnt-targeted therapies.
Article
Biochemical Research Methods
Kyung-Pil Ko, Jie Zhang, Jae-Il Park
Summary: The article presents an efficient and cost-effective protocol for generating and culturing primary mouse esophageal organoids (EOs), as well as establishing transgenic EOs using viral transduction.
Article
Clinical Neurology
Hee Kee Kim, Jingi Bae, Sung Ho Lee, Seon-Hee Hwang, Min-Sik Kim, Moon Jong Kim, Sohee Jun, Chris L. Cervantes, Youn-Sang Jung, Seunghoon Back, Hangyeore Lee, Seung-Eun Lee, Patrick M. Dougherty, Sang-Won Lee, Jae-Il Park, Salahadin Abdi
Summary: Chemotherapy can increase the risk of chemotherapy-induced neuropathic pain (CINP), but blocking the Wnt signaling pathway can prevent and ameliorate this pain, providing a new approach for the prevention and treatment of CINP.