Article
Gastroenterology & Hepatology
Tao Wan, Jun Zheng, Rucheng Yao, Shuang Yang, Weihong Zheng, Pei Zhou
Summary: In this study, it was found that DDX11-AS1 is upregulated in HCC, and its silencing can inhibit HCC cell proliferation, migration, invasion, and glucose metabolism while promoting apoptosis. Additionally, DDX11-AS1 interacts with miR-195-5p and MACC1, suggesting it may serve as a potential therapeutic target for HCC.
ANNALS OF HEPATOLOGY
(2021)
Article
Oncology
Yalin Lu, Gaochao Guo, Rujun Hong, Xingjie Chen, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Jun Dong, Kai Yu, Xuejun Yang, Yang Nan, Qiang Huang
Summary: In this study, it was found that lncRNA HAS2-AS1 is upregulated in GBM cell lines and predominantly localized in the cytoplasm. High expression of HAS2-AS1 in vitro promoted proliferation, while knockdown of HAS2-AS1 significantly inhibited proliferation. Additionally, HAS2-AS1 acted as a ceRNA for miR-137, leading to the derepression of its downstream target LSD1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jen-Hao Yang, Ming-Wen Chang, Dimitrios Tsitsipatis, Xiaoling Yang, Jennifer L. Martindale, Rachel Munk, Aiwu Cheng, Elizabeth Izydore, Poonam R. Pandey, Yulan Piao, Krystyna Mazan-Mamczarz, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe
Summary: In this study, the researchers discovered a noncoding RNA regulatory network that promotes myoblast fusion into multinucleated myotubes by modulating the degradation of miR-7.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Jin Hu, Haohao Huang, Zihan Xi, Shenghui Ma, Jie Ming, Fang Dong, Hui Guo, Huiqiong Zhang, Ende Zhao, Guojie Yao, Liu Yang, Feng Zhang, Wuping Zheng, Hengyu Chen, Tao Huang, Lei Li
Summary: In this study, the researchers investigated the functional role of a novel long noncoding RNA SEAS1 in breast cancer progression. They found that SEAS1 was downregulated in TNBC tissues and its knockdown increased the proliferation, migration, and invasion of TNBC cell lines. They also discovered that SEAS1 acted as a sponge for miR-3940-3p, preventing the degradation of its target gene KLLN, which acts as a tumor inhibitor. Additionally, they demonstrated that SMAD3 directly interacted with the promoter of SEAS1 and suppressed its transcription, thereby promoting TNBC progression. Their findings suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shuai Xue, Fengqin Lu, Chunhui Sun, Jingjing Zhao, Honghua Zhen, Xin Li
Summary: The study revealed that ZEB1-AS1 is upregulated and miR-23c is downregulated in HCC tissues and cell lines. Knockdown of ZEB1-AS1 inhibited the proliferation and invasion of HCC cells, and it was shown that miR-23c is a target of ZEB1-AS1.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zhaoping Che, Jie Xueqin, Zongyu Zhang
Summary: The research showed that OIP5-AS1 influences the evolution of intervertebral disc degeneration by targeting miR-25-3p. Silencing OIP5-AS1 promotes nucleus pulposus cell proliferation, inhibits apoptosis and extracellular matrix degradation, and suppresses inflammation response.
Article
Environmental Sciences
Qiying Yao, Li Zhang, Zhengjuan Liu, Lei Yu, Yuchuan Wang, Junli Liu, Yingjie Wang
Summary: The overexpression of MAFG-AS1 in AML cells and specimens was found to be associated with increased cell growth, cycle, and EMT. Meanwhile, miR-147b was downregulated in AML and negatively correlated with MAFG-AS1. MAFG-AS1 accelerated AML progression by modulating the miR-147b/HOXA9 axis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ji-Hye Choi, So M. Kwon, Sung U. Moon, Sarah Yoon, Masaud Shah, Byoung G. Lee, Jieun Yang, Young N. Park, Hee-Jung Wang, Hyun G. Woo
Summary: Through RNA-Seq analysis, the study identified TPRG1-AS1 as a potential driver noncoding RNA that promotes heterogeneous progression of liver cancer. TPRG1-AS1 induces tumor suppressor RBM24, activating apoptotic tumor cell death to suppress tumor growth, and acts as a ceRNA interfering with the binding of miR-4691-5p and miR-3659 to RBM24.
LIVER INTERNATIONAL
(2021)
Article
Genetics & Heredity
Daowen Ye, Jun Ma, Tingdong Yu, Fengming Ran, Yong Zha
Summary: This study identified a novel lncRNA, FAM13A-AS1, which promotes the proliferation of DDP-resistant HCC cells and elucidates its upstream and downstream mechanisms in the progression of HCC DDP-resistance.
Article
Cell Biology
Xiangkun Wu, Lihua Yan, Yongxi Liu, Lilin Shang
Summary: This study demonstrates that ROR1-AS1 acts as an oncogene in osteosarcoma by regulating miR-504 expression and influencing cell migration and proliferation. The expression of ROR1-AS1 is lower in osteosarcoma tissues compared to non-tumor samples, showing a negative correlation with miR-504 expression.
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Qingyun Pan, Ying Huang, Yirui Wang, Deke Li, Changjiang Lei
Summary: ACTA2-AS1 is downregulated in colon adenocarcinoma, and it suppresses the progression of colon adenocarcinoma by sponging miR-4428 to regulate BCL2L11 expression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jinlin Jia, Hongle Li, Jie Chu, Jinxiu Sheng, Chang Wang, Zimo Jia, Weiwei Meng, Huiqing Yin, Junhu Wan, Fucheng He
Summary: This study found that FAM83A-AS1 is highly expressed in ESCC tissues and is associated with TNM stages and differentiation grade of patients, showing high accuracy in ESCC diagnosis. Inhibiting FAM83A-AS1 can suppress cell proliferation, migration, and invasion in ESCC. FAM83A-AS1 facilitates ESCC progression by regulating the miR-214/CDC25B axis.
Article
Cell & Tissue Engineering
Z. Li
Summary: The study aims to explore the role of lncRNA PCBP1-AS1 in the pathogenesis of osteoporosis. The results suggest that PCBP1-AS1 regulates the proliferation and osteogenic differentiation capacity of human bone marrow-derived mesenchymal stem cells and promotes the expression of PAK2 through competitive binding with miR-126-5p, thereby promoting the progression of osteoporosis.
BONE & JOINT RESEARCH
(2023)
Article
Oncology
Chengren Li, Xu Liang, Yongguang Liu
Summary: The downregulation of USP30-AS1 and upregulation of miR-765 were observed in colon cancer tissues, with a negative correlation between their expression levels. The downregulation of USP30-AS1 was associated with malignant progression and served as an adverse prognostic indicator for colon cancer. USP30-AS1 suppressed the progression of colon cancer by modulating miR-765.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
