Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lina Qi, Jiani Chen, Biting Zhou, Kailun Xu, Kailai Wang, Zhihao Fang, Yingkuan Shao, Ying Yuan, Shu Zheng, Wangxiong Hu
Summary: HOXC6 is overexpressed in right-sided colon cancer and promotes migration and invasion of colon cancer cells by activating the Wnt/beta-catenin signaling pathway. Silencing of HOXC6 can make colon cancer cells more sensitive to irinotecan.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsaeter, Michael Vanlandewijck, Bojana Jakic, Eulalia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Maekinen
Summary: Researchers have identified a new subtype of lymphatic endothelial cells called iLECs, which are positive for Ptx3 and are involved in PI3K-driven lymphatic malformations. These cells recruit pro-lymphangiogenic macrophages and promote pathological lymphatic vessel growth. Understanding the specific disease pathogenesis of different vessel types could lead to the development of more efficient therapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Michael Rangel, Jerry Kong, Vrushank Bhatt, Khoosheh Khayati, Jessie Yanxiang Guo
Summary: Autophagy is a crucial cellular process that degrades waste and recycles nutrients to maintain cellular homeostasis. In cancer, upregulated autophagy supports tumor growth and survival through various mechanisms, making it a potential target for novel cancer treatments.
Review
Biochemistry & Molecular Biology
Fabrice Tolle, Viktor Umansky, Jochen Utikal, Stephanie Kreis, Sabrina Brechard
Summary: Neutrophils, once underestimated in cancer research, now are recognized for their dual roles in tumorigenesis. While they can promote tumor progression, they also possess anti-tumorigenic properties, highlighting the importance of understanding their functions for developing effective therapeutic strategies in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Lothar C. Dieterich, Carlotta Tacconi, Luca Ducoli, Michael Detmar
Summary: The lymphatic system is an important transport system in the human body, playing a crucial role in normal physiology and disease pathogenesis. The role of tumor-associated lymphatic vessels and lymphangiogenesis in lymph node metastasis has been well studied, but the mechanisms and relationship between lymphatic vessels and the dissemination of cancer cells to peripheral organs are still not fully understood. Lymphatic vessels also serve as a communication channel between tumors and the host immune system. Lymphatic endothelial cells have recently been recognized as regulators of tumor immunity and immunotherapy responsiveness.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Rong Guo, Miao Deng, Jiaxin Li, Xuan He, Penghui He, Houqin Liu, Yunxia Ye, Ziyi Mo, Xuan He, Man Li, Qin He
Summary: Blood and lymph are two main pathways of tumor metastasis, and inhibiting both hematogenous and lymphatic metastasis is challenging. Ferroptosis provides a new breakthrough for metastasis inhibition, but effectively triggering it in tumor cells is a major challenge. This study constructed a nanoplatform DA/RSL3 for codelivering arachidonic acid (AA) and RSL3, effectively inducing ferroptosis and alleviating ferroptosis resistance in tumor cells. The nanotherapy showed promising efficacy in inhibiting tumor metastasis in both blood and lymph, making it a potential treatment for metastatic cancer.
Review
Cell Biology
Hengbo Zhou, Pin-ji Lei, Timothy P. Padera
Summary: The review focuses on the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes, and further spread to other distant organs. It discusses emerging molecular targets and potential strategies to inhibit lymph node metastasis.
Article
Oncology
Shailendra Kumar Gangwar, Aviral Kumar, Sandra Jose, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Oral cancer is a global concern and targeting nuclear receptors could be a potential strategy for the prevention and treatment of oral malignancies.
Article
Immunology
Mei-Ling Dong, Xu Wen, Xin He, Ji-Hua Ren, Hai-Bo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng-Tao Cheng, Juan Chen
Summary: The study found that DDX17 plays an important role in the replication of HBV and the metastasis of HBV-related HCC. By promoting HBV replication and transcription as well as HBx-mediated HCC metastasis, DDX17 has a promotive effect on the development of HBV and HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Takanobu Kabasawa, Rintaro Ohe, Naing Ye Aung, Yuka Urano, Takumi Kitaoka, Nobuyuki Tamazawa, Aya Utsunomiya, Mitsunori Yamakawa
Summary: This study reveals that in papillary thyroid carcinoma (PTC), tumor-associated macrophages (TAMs) may influence lymphatic invasion of cancer cells by damaging lymphatic vessels together with cancer cells. An increase in TAMs was observed in PTC, and a significant correlation between M2 cells inside and outside the lymphatic vessels was found.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Medicine, Research & Experimental
Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun
Summary: Our study investigates the role and mechanism of SIX1 upregulation in breast cancer carcinogenesis. We found that SIX1 expression varies among different subtypes of breast cancer and that it upregulates breast cancer grading and lymph node metastasis. Additionally, SIX1 participates in the rewiring of several cancer signaling pathways and interacts with cancer stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Wenlong Wang, Ying Ding, Yunzhe Zhao, Xinying Li
Summary: This study reveals that IGF2BP2 promotes lymphatic metastasis in papillary thyroid carcinoma (PTC) by stabilizing DPP4 in an m6A-dependent manner. Silencing of IGF2BP2 inhibits PTC cell growth and invasion, and increases sensitivity to cisplatin therapy.
CANCER GENE THERAPY
(2023)
Review
Oncology
Jian Li
Summary: Claudin proteins play crucial roles in maintaining tissue integrity and human health, and are associated with signal transduction and tumorigenesis. Their diverse roles in tumor biology make them potential targets for treatment or biomarkers for cancer diagnosis and prognosis. Factors such as organ type, environmental context, and genetic confounders need to be considered when studying the biological functions and targeting of claudins in cancer.
FRONTIERS IN ONCOLOGY
(2021)