β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin

IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient β2-spectrin+/− mice

(2017) Abhisek Mitra et al.   HEPATOLOGY

TGF-β signaling in liver and gastrointestinal cancers

(2016) L.H. Katz et al.   CANCER LETTERS

Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability

(2016) Jian Chen et al.   HEPATOLOGY

Cancer Stem cells and their cellular origins in primary liver and biliary tract cancers

(2016) Tsunekazu Oikawa   HEPATOLOGY

Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis

(2016) Kwang Hwa Jung et al.   HEPATOLOGY

βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin

(2015) Xiuling Zhi et al.   HEPATOLOGY

CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo

(2015) Xing-Xing He et al.   TUMOR BIOLOGY

CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo

(2015) Xingxing He et al.   TUMOR BIOLOGY

 -Catenin Activation in a Novel Liver Progenitor Cell Type Is Sufficient to Cause Hepatocellular Carcinoma and Hepatoblastoma

(2014) S. Mokkapati et al.   CANCER RESEARCH

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

(2013) Floriane Pez et al.   JOURNAL OF HEPATOLOGY

Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma

(2012) Terence Kin Wah Lee et al.   CANCER LETTERS

β-2 Spectrin is involved in hepatocyte proliferation through the interaction of TGFβ/Smad and PI3K/AKT signalling

(2012) Zhijun Wang et al.   LIVER INTERNATIONAL

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice

(2011) Xin Zeng et al.   HEPATOLOGY

Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells

(2011) Wen Sun et al.   HEPATOLOGY

Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis

(2011) Zhijun Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Depletion of  -catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development

(2011) E.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cells and hepatocellular carcinoma

(2010) Zhixing Yao et al.   CANCER BIOLOGY & THERAPY

Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer

(2010) Hye Jung Baek et al.   HEPATOLOGY

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice

(2010) Arun Thenappan et al.   HEPATOLOGY

Nuclear β-Catenin Induces an Early Liver Progenitor Phenotype in Hepatocellular Carcinoma and Promotes Tumor Recurrence

(2009) Gudrun Zulehner et al.   AMERICAN JOURNAL OF PATHOLOGY

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

(2008) Stefano Cairo et al.   CANCER CELL

Wnt/ -Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells

(2008) W. Yang et al.   CANCER RESEARCH

Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis

(2008) Hye Jung Baek et al.   HEPATOLOGY

Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4α gene

(2008) Chuan Yin et al.   HEPATOLOGY

Liver stem cells and hepatocellular carcinoma

(2008) Lopa Mishra et al.   HEPATOLOGY

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-  and IL-6 signaling

(2008) Y. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA