Biased signaling in naturally occurring mutations of G protein-coupled receptors associated with diverse human diseases

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

(2020) Sarah Paisdzior et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

(2020) Carl-Mikael Suomivuori et al.   SCIENCE

Biased Signaling of the G-Protein-Coupled Receptor β2AR Is Governed by Conformational Exchange Kinetics

(2020) Rajan Lamichhane et al.   STRUCTURE

Impact of GPCR Structures on Drug Discovery

(2020) Miles Congreve et al.   CELL

Molecular chaperones and G protein-coupled receptor maturation and pharmacology

(2020) Ya-Xiong Tao   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

(2019) Laura M. Wingler et al.   CELL

Biased Receptor Signaling in Drug Discovery

(2019) Terry Kenakin   PHARMACOLOGICAL REVIEWS

Strategies for the discovery of biased GPCR ligands

(2019) Marcel Bermudez et al.   DRUG DISCOVERY TODAY

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

(2019) Luca A. Lotta et al.   CELL

Structural Insights into CB1 Receptor Biased Signaling

(2019) Al-Zoubi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential

(2019) Mohammad Seyedabadi et al.   PHARMACOLOGY & THERAPEUTICS

Obesity‐associated mutant MC4 receptors with normal Gα s coupling frequently exhibit other discoverable pharmacological and biochemical defects

(2019) Taneisha Gillyard et al.   JOURNAL OF NEUROENDOCRINOLOGY

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias

(2018) Caroline M Gorvin et al.   HUMAN MOLECULAR GENETICS

Insights into calcium-sensing receptor trafficking and biased signalling by studies of calcium homeostasis

(2018) Caroline M Gorvin   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

(2018) Caroline M. Gorvin et al.   Science Signaling

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

(2018) Caroline M. Gorvin et al.   Cell Reports

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

(2018) Caroline M. Gorvin et al.   Science Signaling

Fenoprofen -- an old drug rediscovered as a biased allosteric enhancer for melanocortin receptors

(2018) Xiao-Chen Yuan et al.   ACS Chemical Neuroscience

Melanocortin-4 receptor in swamp eel ( Monopterus albus ): Cloning, tissue distribution, and pharmacology

(2018) Ti-Lin Yi et al.   GENE

GPCR structure and function relationship: identification of a biased apelin receptor mutant

(2018) Ting Ban et al.   BIOCHEMICAL JOURNAL

PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα-protein leads to biased signaling

(2018) Yaguang Zhao et al.   FASEB JOURNAL

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

(2017) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-arrestin signalling and bias in hormone-responsive GPCRs

(2017) Eric Reiter et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

(2017) Jo Ann Janovick et al.   PLoS One

Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

(2017) Jialu Wang et al.   Nature Communications

A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors

(2017) Jaimee Gundry et al.   Frontiers in Neuroscience

Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors

(2016) Zhao Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3

(2016) Trinidad Montero-Melendez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking

(2016) Anatoly Tiulpakov et al.   MOLECULAR ENDOCRINOLOGY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Recent updates on GPCR biased agonism

(2016) André S. Pupo et al.   PHARMACOLOGICAL RESEARCH

Structural mechanism of ligand activation in human calcium-sensing receptor

(2016) Yong Geng et al.   eLife

Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene

(2015) Fan Yang et al.   International Journal of Biological Sciences

Biased Signaling at Chemokine Receptors

(2015) Jenny Corbisier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G Protein-coupled Receptor (GPCR) Signaling via Heterotrimeric G Proteins from Endosomes

(2015) Nikoleta G. Tsvetanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gq/11α and Gsα mediate distinct physiological responses to central melanocortins

(2015) Yong-Qi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects

(2015) Trinidad Montero-Melendez et al.   JOURNAL OF IMMUNOLOGY

Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor

(2015) Zhao Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mutation in the V2 vasopressin receptor gene, AVPR2, causes nephrogenic syndrome of inappropriate diuresis

(2015) László S. Erdélyi et al.   KIDNEY INTERNATIONAL

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

PTH receptor-1 signalling—mechanistic insights and therapeutic prospects

(2015) Ross W. Cheloha et al.   Nature Reviews Endocrinology

Intracellular signaling mechanisms of the melanocortin receptors: current state of the art

(2014) Adriana R. Rodrigues et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor

(2014) Wenqing Yin et al.   CELLULAR SIGNALLING

Biased ligands: pathway validation for novel GPCR therapeutics

(2014) David H Rominger et al.   CURRENT OPINION IN PHARMACOLOGY

Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

(2014) Ya-Xiong Tao et al.   ENDOCRINE REVIEWS

KISS1R Signals Independently of Gαq/11and Triggers LH Secretion via the β-Arrestin Pathway in the Male Mouse

(2014) Maryse Ahow et al.   ENDOCRINOLOGY

Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations

(2014) Oualid Sbai et al.   FASEB JOURNAL

Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin-1 receptor in the grey squirrel (Sciurus carolinensis)

(2014) Helen R. McRobie et al.   FEBS LETTERS

Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene

(2014) Shan He et al.   International Journal of Biological Sciences

G Protein and β-Arrestin Signaling Bias at the Ghrelin Receptor

(2014) Tama Evron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Serine 348 on the Apelin Receptor as a Novel Regulatory Phosphorylation Site in Apelin-13-induced G Protein-independent Biased Signaling

(2014) Xiaoyu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of the DRY motif and intracellular loop 2 of human melanocortin 3 receptor

(2014) Hui Huang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mutations in the ‘DRY’ motif of the CB1 cannabinoid receptor result in biased receptor variants

(2014) Pál Gyombolai et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Emerging structural insights into biased GPCR signaling

(2014) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism

(2013) Fadil M. Hannan et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Role of the calcium-sensing receptor in extracellular calcium homeostasis

(2013) Edward M. Brown   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Functional analysis of the distal region of the third intracellular loop of PROKR2

(2013) Xiao-Tao Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors

(2013) Xiu-Lei Mo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

(2013) Jong-Woo Sohn et al.   CELL

Trp64Arg (rs4994) polymorphism of β3-adrenergic receptor gene is associated with hyperuricemia in a Chinese male population

(2013) Qiong Huang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Selectivity of 6′-Guanidinonaltrindole (6′-GNTI) at κ-Opioid Receptors in Striatal Neurons

(2013) Cullen L. Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline Prokineticin Receptor 2 (PROKR2) Variants Associated With Central Hypogonadism Cause Differental Modulation of Distinct Intracellular Pathways

(2013) Domenico Vladimiro Libri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

(2013) Xiao-Tao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distinct CCK-2 Receptor Conformations Associated with β-Arrestin-2 Recruitment or Phospholipase-C Activation Revealed by a Biased Antagonist

(2013) Rémi Magnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways

(2013) Kai J. Kohlhoff et al.   Nature Chemistry

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)

(2013) Stephen P. Armstrong et al.   PLoS One

Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH

(2013) A. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex

(2013) Vanessa L. Wehbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Adrenergic receptor subtype signaling in heart: From bench to bedside

(2012) Anthony Yiu Ho Woo et al.   ACTA PHARMACOLOGICA SINICA

Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor

(2012) Katie Leach et al.   ENDOCRINOLOGY

Gsα Deficiency in the Paraventricular Nucleus of the Hypothalamus Partially Contributes to Obesity Associated with Gsα Mutations

(2012) Min Chen et al.   ENDOCRINOLOGY

Melanocortin-3 receptors are involved in adaptation to restricted feeding

(2012) K. Begriche et al.   GENES BRAIN AND BEHAVIOR

6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment

(2012) Marie-Laure Rives et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of transmembrane domain 3 of human melanocortin-4 receptor

(2012) Xiu-Lei Mo et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor

(2012) Hui Huang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Identification and Characterization of an Activating F229V Substitution in the V2 Vasopressin Receptor in an Infant with NSIAD

(2012) E. Carpentier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Normal testicular function without detectable follicle-stimulating hormone. A novel mutation in the follicle-stimulating hormone receptor gene leading to apparent constitutive activity and impaired agonist-induced desensitization and internalization

(2012) Patricia Casas-González et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evidence of the Importance of the First Intracellular Loop of Prokineticin Receptor 2 in Receptor Function

(2012) Ana Paula Abreu et al.   MOLECULAR ENDOCRINOLOGY

Melanocortin-Induced PKA Activation Inhibits AMPK Activity Via ERK-1/2 and LKB-1 in Hypothalamic GT1-7 Cells

(2012) Ellen Damm et al.   MOLECULAR ENDOCRINOLOGY

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3

(2012) M Andrew Nesbit et al.   NATURE GENETICS

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Biased agonism of the calcium-sensing receptor

(2011) Alex Rojas Bie Thomsen et al.   CELL CALCIUM

Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

(2011) Anna E. Davey et al.   ENDOCRINOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

G protein-coupled receptors: mutations and endocrine diseases

(2011) Gilbert Vassart et al.   Nature Reviews Endocrinology

The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling

(2011) Tau Benned-Jensen et al.   PLoS One

Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications

(2011) Brian J. Arey et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions

(2010) Luis Teixeira et al.   JOURNAL OF CLINICAL INVESTIGATION

Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation☆

(2010) Thibaud Tranchant et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling

(2010) Andreas Breit et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Functional Characterization of Vasopressin Type 2 Receptor Substitutions (R137H/C/L) Leading to Nephrogenic Diabetes Insipidus and Nephrogenic Syndrome of Inappropriate Antidiuresis: Implications for Treatments

(2010) M. D. Rochdi et al.   MOLECULAR PHARMACOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population

(2010) Pauline Chaste et al.   PLoS One

Central Nervous System Imprinting of the G Protein Gsα and Its Role in Metabolic Regulation

(2009) Min Chen et al.   Cell Metabolism

Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways

(2009) Cecilia Herraiz et al.   FEBS LETTERS

Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients

(2009) Ana B. Pérez Oliva et al.   HUMAN MUTATION

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus

(2009) F. Jean-Alphonse et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of GPR54 Signaling by GRK2 and β-Arrestin

(2009) Macarena Pampillo et al.   MOLECULAR ENDOCRINOLOGY

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Sleep problems in autism spectrum disorders: Prevalence, nature, & possible biopsychosocial aetiologies

(2009) Amanda L. Richdale et al.   SLEEP MEDICINE REVIEWS

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Differing pharmacological activities of thiazolidinone analogs at the FSH receptor

(2008) Brian J. Arey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

(2008) R Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disease-causing Mutation in GPR54 Reveals the Importance of the Second Intracellular Loop for Class A G-protein-coupled Receptor Function

(2008) Jennifer L. Wacker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AVPR2 variants and mutations in nephrogenic diabetes insipidus: Review and missense mutation significance

(2008) Elias Spanakis et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

AGPR54-Activating Mutation in a Patient with Central Precocious Puberty

(2008) Milena Gurgel Teles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modulation of Blood Pressure by Central Melanocortinergic Pathways

(2008) Jerry R. Greenfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intracellular signaling pathways activated by kisspeptins through GPR54: Do multiple signals underlie function diversity?

(2008) Justo P. Castaño et al.   PEPTIDES

Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics

(2008) Y TAO   PHARMACOLOGY & THERAPEUTICS

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

(2008) M. Okazaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Blockers alprenolol and carvedilol stimulate  -arrestin-mediated EGFR transactivation

(2008) I.-M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Motifs of Neuropeptide Y Receptors Differentially Regulate Trafficking and Desensitization

(2008) Moussa Ouedraogo et al.   TRAFFIC

G12/G13-mediated signalling in mammalian physiology and disease

(2008) Thomas Worzfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G-protein-coupled receptors: past, present and future

(2006) Stephen J Hill   BRITISH JOURNAL OF PHARMACOLOGY