Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment

(2019) Peter Kühnen et al.   TRENDS IN MOLECULAR MEDICINE

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

(2019) Luca A. Lotta et al.   CELL

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

(2019) Nicolas Heyder et al.   Frontiers in Endocrinology

Obesity‐associated mutant MC4 receptors with normal Gα s coupling frequently exhibit other discoverable pharmacological and biochemical defects

(2019) Taneisha Gillyard et al.   JOURNAL OF NEUROENDOCRINOLOGY

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

(2019) Grazia Rutigliano et al.   Frontiers in Pharmacology

Quantifying the polygenic contribution to variable expressivity in eleven rare genetic disorders

(2019) M. T. Oetjens et al.   Nature Communications

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

(2018) Julia Bräunig et al.   Frontiers in Pharmacology

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation

(2017) Terry Kenakin   MOLECULAR PHARMACOLOGY

Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists

(2016) David Winpenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene

(2016) Laura Schonnop et al.   Obesity

Gq/11α and Gsα mediate distinct physiological responses to central melanocortins

(2015) Yong-Qi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene

(2014) Shan He et al.   International Journal of Biological Sciences

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity

(2014) Vita Rovite et al.   MOLECULAR BIOLOGY REPORTS

Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors

(2013) Xiu-Lei Mo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2

(2013) Carolin L Piechowski et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2

(2013) Maria Josep Agulleiro et al.   MOLECULAR ENDOCRINOLOGY

Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish

(2013) J. A. Sebag et al.   SCIENCE

Clinical and Functional Relevance of Melanocortin-4 Receptor Variants in Obese German Children

(2012) Christin Melchior et al.   Hormone Research in Paediatrics

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

(2011) M. S. Thearle et al.   DIABETES

Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response

(2010) Pierre Roubert et al.   JOURNAL OF ENDOCRINOLOGY

Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

(2009) Nicola Santoro et al.   BMC Medical Genetics

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

(2009) Zhen-Chuan Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case–control Study and Meta-analysis in 55,195 Individuals

(2009) Du Wang et al.   Obesity

Increased constraints on MC4R during primate and human evolution

(2008) David A. Hughes et al.   HUMAN GENETICS

Association of the MC4R V103I Polymorphism With the Metabolic Syndrome: The KORA Study

(2008) Iris M. Heid et al.   Obesity