Article
Cell Biology
Veronica Murcia-Belmonte, Maria Tercero-Diaz, Diego Barrasa-Martin, Sandra Lopez de la Vieja, Marina Munoz-Lopez, Pedro F. Esteban
Summary: The X-linked form of Kallmann syndrome is caused by mutations in the ANOS1 gene, resulting in hypogonadotropic hypogonadism and anosmia. This study reveals that anosmin 1 can enhance the activation of the PK2/PKR2 pathway and modulate its biological effects. The N-terminal region of anosmin 1 interacts with PKR2, and the whey acidic protein domain is necessary for this modulatory activity, while the cysteine-rich and FnIII.1 domains may assist in binding to PKR2 and regulating receptor activation by PK2.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Roberta Lattanzi, Cinzia Severini, Rossella Miele
Summary: Inflammation plays a crucial role in tumor progression. Prokineticin 2 is involved in tumor growth, angiogenesis, and metastasis. In addition to its function as an angiogenic factor and a mediator of immune cell migration, prokineticin 2 also suppresses tumor cell apoptosis, promotes their proliferation and movements necessary for metastasis. It is also associated with tumor pain and resistance responses, and may serve as a potential prognostic tumor biomarker.
Review
Biochemistry & Molecular Biology
Carla Petrella, Matteo Spaziani, Valerio D'Orazi, Luigi Tarani, Sergio Terracina, Francesca Tarani, Ginevra Micangeli, Christian Barbato, Antonio Minni, Antonio Greco, Andrea M. Isidori, Giampiero Ferraguti, Marco Fiore
Summary: Male infertility accounts for about 50% of infertility in couples, with the diagnosis and treatment process being crucial in understanding the biological origins of infertility and potential therapeutic interventions. The prokineticin system, particularly PROK2, plays a significant role in male infertility by offering new insights into testicular pathophysiology and potential therapeutic hypotheses.
Article
Biochemistry & Molecular Biology
Chao Li, Li -fang Lv, Mu-ge Qi-Li, Rui Yang, Yu-jing Wang, Shuang-shuang Chen, Ming-xiu Zhang, Tian-yu Li, Tong Yu, Yu-hong Zhou, Hai-hai Liang, Hong-li Shan, Xue-lian Li
Summary: In this study, the researchers found that serpinE2 can be translocated into cardiac fibroblasts through endocytosis by interacting with membrane proteins LRP1 and uPAR. This process activates the ERK1/2 and β-catenin signaling pathways, consequently promoting collagen production.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Claudia Metz, Claudia Oyanadel, Juan Jung, Claudio Retamal, Jorge Cancino, Jonathan Barra, Jaime Venegas, Guangwei Du, Andrea Soza, Alfonso Gonzalez
Summary: The PA/PDE4/PKA pathway triggers EGFR endocytosis through activation of p38 and ERK1/2, expanding the potential for EGFR transmodulation and interference in cancer.
Review
Pharmacology & Pharmacy
Roberta Lattanzi, Cinzia Severini, Daniela Maftei, Luciano Saso, Aldo Badiani
Summary: The Prokineticin family, specifically Prokineticin 1 and Bv8/Prokineticin 2 (PROK2), interact with G protein-coupled receptors to regulate various biological functions in the central nervous system. Pathological insults can increase PROK2 expression levels and potentially contribute to neurodegenerative diseases. Despite documented physiological effects, the role of PROK2 and its receptors in neuropathological conditions remains unclear.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana Martin-Vega, Melanie H. Cobb
Summary: The RAS-ERK pathway is crucial for various biological processes and its aberrant activation is implicated in diseases such as cancer. This review focuses on the structure, activation, regulation, and mutational frequency of the pathway, with an emphasis on ERK1/2. The significance of scaffold proteins in kinase localization and interaction dynamics is highlighted, along with potential therapeutic approaches in this field.
Article
Clinical Neurology
Tommaso Schirinzi, Daniela Maftei, Francesco M. Passali, Piergiorgio Grillo, Henri Zenuni, Davide Mascioli, Riccardo Maurizi, Laura Loccisano, Martina Vincenzi, Anna Maria Rinaldi, Massimo Ralli, Stefano Di Girolamo, Alessandro Stefani, Roberta Lattanzi, Cinzia Severini, Nicola B. Mercuri
Summary: This study outlines the dynamics of the prokineticin-2 pathway in relation to the clinical-pathological features of Parkinson's disease by examining olfactory neurons of patients. The results show that prokineticin-2 expression is increased in Parkinson's disease and is directly correlated with the severity of motor symptoms. Additionally, the accumulation of oligomeric alpha-synuclein is associated with prokineticin-2 protein levels. These findings support prokineticin-2 as a potential target for Parkinson's disease and validate the use of olfactory neurons to reflect pathological changes of the disease.
ANNALS OF NEUROLOGY
(2023)
Article
Infectious Diseases
Qianqian Tu, Xiaoyan Yu, Wei Xie, Yetao Luo, Hong Tang, Kai Chen, Yanting Ruan, Yue Li, Jie Zhou, Yibing Yin, Dapeng Chen, Zhixin Song
Summary: This study investigated the role of Prokineticin 2 (PK2) in bacterial pneumonia. The levels of PK2 were found to be decreased in patients with pneumonia compared to healthy controls, and even lower in patients with severe pneumonia. Administering recombinant PK2 in a mouse model of bacterial pneumonia alleviated lung injury, improved survival, and enhanced the host's bacterial clearance capacity. PK2 was shown to enhance the chemotaxis, phagocytosis, and killing ability of macrophages.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Zhongyuan Bao, Yinlong Liu, Binglin Chen, Zong Miao, Yiming Tu, Chong Li, Honglu Chao, Yangfan Ye, Xiupeng Xu, Guangchi Sun, Pengzhan Zhao, Ning Liu, Yan Liu, Xiaoming Wang, Sin Man Lam, Valerian E. Kagan, Hulya Bayir, Jing Ji
Summary: Prokineticin-2 (Prok2) prevents neuronal cell ferroptosis after traumatic brain injury by regulating lipid peroxidation, and its administration before cortical injury reduces neuronal degeneration and improves motor and cognitive functions. This neuroprotective effect may be mediated through mechanisms involving Fbxo10.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Daniela Maftei, Tommaso Schirinzi, Nicola B. Mercuri, Roberta Lattanzi, Cinzia Severini
Summary: The immune system plays a crucial role in neurodegenerative diseases, and the chemokine PK2 is an important player in these diseases. The potential clinical value of PK2 as a disease biomarker or therapeutic target for Alzheimer's disease and Parkinson's disease is discussed.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liqing Song, Daniel E. Oseid, Evan A. Wells, Troy Coaston, Anne S. Robinson
Summary: This study reveals that soluble tau monomers can be easily internalized by cells through actin-dependent macropinocytosis. The process of internalization is regulated by HSPGs, activates ERK1/2, induces inflammation, and is mediated by the presence of LRP1.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Infectious Diseases
Qianqian Tu, Xiaoyan Yu, Wei Xie, Yetao Luo, Hong Tang, Kai Chen, Yanting Ruan, Yue Li, Jie Zhou, Yibing Yin, Dapeng Chen, Zhixin Song
Summary: Decreased levels of PK2 may contribute to impaired alveolar macrophage function, leading to the occurrence and development of bacterial pneumonia. Administration of recombinant PK2 may serve as a potential adjuvant therapy for bacterial pneumonia.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biology
Roberta Lattanzi, Daniela Maftei, Martina Vincenzi, Maria Rosaria Fullone, Rossella Miele
Summary: This study characterized a new alternatively spliced product of the prok2 gene called PROK2C, which is expressed in the hippocampus and spinal cord of mice. It was found that PROK2C can bind and activate both PROKR1 and PROKR2, and it induces sensitization of peripheral nociceptors to painful stimuli.
Article
Multidisciplinary Sciences
Ewelina Goryszewska-Szczurek, Monika Baryla, Piotr Kaczynski, Agnieszka Waclawik
Summary: Prokineticin 1 plays a pleiotropic role in trophoblast function during implantation and early placentation, with its signaling pathway regulating key functions such as cell proliferation and adhesion. The study also identified the involvement of various signaling pathways, including MAPK, PI3K/AKT/mTOR, and cAMP, in mediating the effects of PROK1 in trophoblasts. The findings suggest that PROK1 has a significant impact on trophoblast development and function in the early stages of pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Jialing Liu, Yi Li, Lingna Lyu, Liang Xiao, Aliza A. Memon, Xin Yu, Arvin Halim, Shivani Patel, Abdikheyre Osman, Wenqing Yin, Jie Jiang, Said Naini, Kenneth Lim, Aifeng Zhang, Jonathan D. Williams, Ruth Koester, Kevin Z. Qi, Quynh-Anh Fucci, Lai Ding, Steven Chang, Ankit Patel, Yutaro Mori, Advika Chaudhari, Aaron Bao, Jia Liu, Tzong-Shi Lu, Andrew Siedlecki
Summary: This study reveals the regulatory role of miR-218-5p in kidney endothelial progenitor cell migration, which may contribute to the development of therapeutic strategies for microvascular kidney injury.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhengxin Chen, Shuai Wang, Hai-Lin Li, Hui Luo, Xiaoting Wu, Jiacheng Lu, Hong-Wei Wang, Yuanyuan Chen, Dan Chen, Wen-Ting Wu, Shuyu Zhang, Qiongqiong He, Daru Lu, Ning Liu, Yongping You, Wei Wu, Huibo Wang
Summary: FOSL1 is a key player in regulating the proneural to mesenchymal transition (PMT) in glioblastoma stem cells (GSCs). It promotes the ionizing radiation-induced PMT and radioresistance of Proneural GSCs. Mechanistically, FOSL1 induces PMT by promoting UBC9-dependent CYLD SUMOylation and subsequent NF-kappa B activation. Therapeutic targeting of FOSL1 holds promise to attenuate molecular subtype switching in glioblastoma patients.
Article
Optics
Dan Chen, Yanrong Liu, Feier Ai, Minghua Cao
Summary: The pulse response expression of the non-line-of-sight underwater laser channel is derived based on the binomial Henyey-Greenstein scattering phase function, considering the forward and backward effects. The effectiveness of the established underwater photon transmission channel model is simulated and verified, showing better fitting effects in coastal waters. The pulse-broadening factor is higher in coastal waters compared to harbor waters, and the time-domain broadening effect of laser pulse transmission is significant in harbor waters, particularly influenced by front scattering when the asymmetry factor is large.
OPTICAL ENGINEERING
(2022)
Article
Mechanics
Danyang Chen, Zhideng Zhou, Xiaolei Yang
Summary: A novel MCPNN-frozen model is proposed in this study for wind resource assessment, utilizing neural networks and frozen flow hypothesis. Results indicate the model performs well under certain conditions.
Article
Multidisciplinary Sciences
Yingwen Hu, Danyang Chen, John Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A. Savran, Philip S. Low
Summary: The combination of folate-biotin conjugates and magnetic beads can efficiently capture tumor cells, which has been validated in both mouse models and non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Liu Jinyu, Wang Shuying, Zheng Panchan, Chen Dan, Chen Chao, Yang Xingyu, Cheng Weiwei
Summary: The expression of BST2 and MMP2 is significantly downregulated in preeclampsia. Overexpression of BST2 can upregulate MMP2 expression and enhance the migration and invasion capacity of trophoblast cells. Knockdown of BST2 or MMP2 has opposite effects. These results suggest that the downregulation of BST2 may play a role in the pathogenesis of preeclampsia.
Article
Engineering, Electrical & Electronic
Yulong Dong, Danyang Chen, Ni Zhong, Jingquan Liu, Chungang Duan, Xiuyan Li
Summary: This article presents an electrostatic model to explain the negative capacitance (NC) effects in ferroelectric (FE) films, and explores the occurrence of NC effects in a specific time window through experimental studies. The key factor determining this time window is the competition between FE switching and charge compensation.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Acoustics
Dandan Chen, Juan Xia, Shurui Xie, Yafeng He, Xiaojing Ma
Summary: This case report highlights the successful diagnosis and treatment of a rare case of unruptured right SOVA using transthoracic echocardiography, contrastive echocardiography, and transesophageal echocardiography.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Chemistry, Analytical
Shen Wang, Yingcui Bu, Xin Lu, Dandan Chen, Zhipeng Yu, Jie Zhang, Lianke Wang, Hongping Zhou
Summary: A specifically cancer cell lysosome targeted pre-photosensitizer with suitable pH-response range has been designed and applied for switch-on photodynamic therapy. The experiments on mice model showed that the pre-photosensitizer is inactive in normal tissue and active in tumor region.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Wang Mingjun, Wang Yuhang, Chen Dan, Zhang Jialin, Li Jianqing
Summary: This study investigates the transmission characteristics of blue-green laser across the air-sea cross-medium by developing a transmission model. Factors such as wind speed, bubble concentration, and mixing of bubbles in seawater are considered. The results show that wind speed and transmission depth are key factors affecting laser transmittance, and the effect of the bubble layer decreases with depth.
ACTA OPTICA SINICA
(2022)
Article
Materials Science, Biomaterials
Limin Chang, Ruixue Chang, Xiaojun Liu, Xiangbo Ma, Danyang Chen, Yong Wang, Wenjuan Li, Jianglei Qin
Summary: In this study, a pectin-based self-healing hydrogel was developed with conjugated polyphosphate for effective hemostasis and wound healing. The hydrogel exhibited self-healing property and sustained release performance, leading to accelerated blood coagulation and wound repair. Moreover, it also prevented bacterial invasion.
BIOMATERIALS ADVANCES
(2022)
Article
Engineering, Electrical & Electronic
Cao Minghua, Wu Zhaoheng, Zhang Wei, Qiu Yan, Xia Jieping, Chen Dan, Wang Huiqin
Summary: In this paper, a hybrid modulated faster-than-Nyquist (PSK-PPM-FTN) rate atmospheric optical communication scheme is proposed, which combines phase-shift keying (PSK) and pulse-position modulation (PPM) to improve the bandwidth utilization and data transmission rate of the system.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Article
Astronomy & Astrophysics
Homare Abe, Tomotada Akutsu, Masaki Ando, Akito Araya, Naoki Aritomi, Hideki Asada, Yoichi Aso, Sangwook Bae, Rishabh Bajpai, Kipp Cannon, Zhoujian Cao, Eleonora Capocasa, Man Leong Chan, Dan Chen, Yi-Ru Chen, Marc Eisenmann, Raffaele Flaminio, Heather K. Fong, Yuta Fujikawa, Yuya Fujimoto, I. Putu Wira Hadiputrawan, Sadakazu Haino, Wenbiao Han, Kazuhiro Hayama, Yoshiaki Himemoto, Naoatsu Hirata, Chiaki Hirose, Tsung-Chieh Ho, Bin-Hua Hsieh, He-Feng Hsieh, Chia-Hsuan Hsiung, Hsiang-Yu Huang, Panwei Huang, Yao-Chin Huang, Yun-Jing Huang, David C. Y. Hui, Kohei Inayoshi, Yuki Inoue, Yousuke Itoh, Pil-Jong Jung, Takaaki Kajita, Masahiro Kamiizumi, Nobuyuki Kanda, Takashi Kato, Chunglee Kim, Jaewan Kim, Young-Min Kim, Yuichiro Kobayashi, Kazunori Kohri, Keiko Kokeyama, Albert K. H. Kong, Naoki Koyama, Chihiro Kozakai, Jun'ya Kume, Sachiko Kuroyanagi, Kyujin Kwak, Eunsub Lee, Hyung Won Lee, Ray-Kuang Lee, Matteo Leonardi, Kwan-Lok Li, Pengbo Li, Lupin Chun-Che Lin, Chun-Yu Lin, En-Tzu Lin, Hong-Lin Lin, Guo-Chin Liu, Ling-Wei Luo, Miftahul Ma'arif, Yuta Michimura, Norikatsu Mio, Osamu Miyakawa, Kouseki Miyo, Shinji Miyoki, Nozomi Morisue, Kouji Nakamura, Hiroyuki Nakano, Masayuki Nakano, Tatsuya Narikawa, Lan Nguyen Quynh, Takumi Nishimoto, Atsushi Nishizawa, Yoshihisa Obayashi, Kwangmin Oh, Masatake Ohashi, Tomoya Ohashi, Masashi Ohkawa, Yoshihiro Okutani, Ken-ichi Oohara, Shoichi Oshino, Kuo-Chuan Pan, Alessandro Parisi, June Gyu Park, Fabian E. Pena Arellano, Surojit Saha, Kazuki Sakai, Takahiro Sawada, Yuichiro Sekiguchi, Lijing Shao, Yutaka Shikano, Hirotaka Shimizu, Katsuhiko Shimode, Hisaaki Shinkai, Ayaka Shoda, Kentaro Somiya, Inhyeok Song, Ryosuke Sugimoto, Jishnu Suresh, Takamasa Suzuki, Takanori Suzuki, Toshikazu Suzuki, Hideyuki Tagoshi, Hirotaka Takahashi, Ryutaro Takahashi, Hiroki Takeda, Mei Takeda, Atsushi Taruya, Takayuki Tomaru, Tomonobu Tomura, Lucia Trozzo, Terrence T. L. Tsang, Satoshi Tsuchida, Takuya Tsutsui, Darkhan Tuyenbayev, Nami Uchikata, Takashi Uchiyama, Tomoyuki Uehara, Koh Ueno, Takafumi Ushiba, Maurice H. P. M. van Putten, Tatsuki Washimi, Chien-Ming Wu, Hsun-Chung Wu, Tomohiro Yamada, Kazuhiro Yamamoto, Takahiro Yamamoto, Ryo Yamazaki, Shu-Wei Yeh, Jun'ichi Yokoyama, Takaaki Yokozawa, Hirotaka Yuzurihara, Simon Zeidler, Yuhang Zhao
Summary: KAGRA is a gravitational-wave detector in Japan with unique features of underground construction and cryogenic cooling. Although its sensitivity to gravitational waves is inferior to other detectors like LIGO and Virgo, further upgrades are being conducted to improve its sensitivity for the next observation run in 2022.
Review
Chemistry, Multidisciplinary
Dan Chen, Yingying Zhang, Yao Xu, Qing Nie, Zhanbin Yang, Wenyu Sheng, Guangren Qian
Summary: This review discusses the application of recycling municipal solid waste incineration (MSWI) residues in construction materials, emphasizing the potential opportunities for the construction and building industry. The paper summarizes the utilization of MSWI residues in four typical building materials and highlights the importance of proper treatment methods to improve the properties of the residues. The study concludes that recycling MSWI residues can provide significant economic and environmental benefits, although further research is needed for treatment methods of fine particles.
Article
Medicine, Research & Experimental
Nkiruka Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A. Walker, Mostafa Belghasem, Jonathan D. Ravid, Mohamed Hassan Kamel, Stephen A. Whelan, Norman Lee, Jeffrey J. Siracuse, Stephan Anderson, Alik Farber, David Sherr, Jean Francis, Naomi M. Hamburg, Nader Rahimi, Vipul C. Chitalia
Summary: Chronic kidney disease (CKD) is an independent risk factor for peripheral artery disease (PAD). The role of uremic solutes retained in CKD patients in PAD is not well understood. This study reveals that tryptophan-derived uremic solutes inhibit beta-catenin, a key regulator of angiogenesis, in several cell types including endothelial cells. These solutes downregulate beta-catenin through the aryl hydrocarbon receptor (AHR). CKD mouse models show reduced beta-catenin and blood vessel density in ischemic limbs, which correlates with increased levels of uremic solutes and AHR activity. In a cohort of PAD patients, higher plasma levels of tryptophan metabolites and increased AHR-inducing activity in endothelial cells are associated with an increased risk of adverse limb events. Targeting the tryptophan metabolite/AHR/beta-catenin axis may provide new therapeutic strategies for PAD in CKD patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
