Review
Endocrinology & Metabolism
Julian Martinez-Mayer, Maria Ines Perez-Millan
Summary: PROKR2 encodes a receptor that binds PROK1 and PROK2. Mutations in PROKR2 can cause abnormal olfactory bulb formation and defects in GnRH neuron migration. Patients with PROKR2 mutations typically present with hypogonadotropic hypogonadism, anosmia/hyposmia, or Kallmann Syndrome. Recent studies have also linked PROKR2 variants to pituitary disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Rahma Mkaouar, Lamia Cherif Ben Abdallah, Chokri Naouali, Saida Lahbib, Zinet Turki, Sahar Elouej, Yosra Bouyacoub, Maali Somai, Kenneth Mcelreavey, Anu Bashamboo, Sonia Abdelhak, Olfa Messaoud
Summary: The study identified genetic mechanisms underlying hypogonadotropic hypogonadism in two Tunisian patients, highlighting the importance of oligogenic inheritance in this disorder. Digenic combination predictions revealed potential disease-causing variant pairs, emphasizing the complexity of genetic factors contributing to Congenital Hypogonadotropic Hypogonadism.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Xinying Wang, Danna Chen, Yaguang Zhao, Meichao Men, Zhiheng Chen, Fang Jiang, Ruizhi Zheng, Maria Stamou, Lacey Plummer, Ravikumar Balasubramanian, Jia-Da Li
Summary: Isolated hypogonadotropic hypogonadism (IHH) is a rare disease caused by defects in the migration, secretion, or signal transduction of gonadotropin-releasing hormone (GnRH). This study analyzed the functional consequences of 23 PROKR2 mutations in IHH patients and categorized them into four groups based on their disruptions of the G alpha q pathway. The results provide a functional database that can guide diagnosis and genetic counseling.
HUMAN MOLECULAR GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Roberto Maggio, Irene Fasciani, Francesco Petragnano, Maria Francesca Coppolino, Marco Scarselli, Mario Rossi
Summary: Unstructured regions in functional proteins, specifically the i3 loop and C-terminus in G protein-coupled receptors (GPCRs), have been recognized as crucial elements in GPCR function and regulation. They play critical roles in allosterically regulating GPCR activation, as autoregulators in receptor coupling specificity, and in facilitating receptor stability and interactions with intracellular protein partners.
Article
Biochemistry & Molecular Biology
Melissa Girard, Steve Dagenais Bellefeuille, Emilie Eiselt, Guillaume Arguin, Jean-Michel Longpre, Philippe Sarret, Fernand-Pierre Gendron
Summary: This study found that endosomal trafficking plays an important role in G protein-coupled receptor (GPCR) signaling. UDP selectively activates GPCR P2Y6 as a signaling molecule. The study found that MRS2693 and UDP have different effects on the internalization of the P2Y6 receptor, with MRS2693 inducing P2Y6 internalization through an independent caveolin-dependent mechanism. This study provides insights for the development of bias ligands that can influence P2Y6 signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Haijun Yuan, Sipeng Deng, Wei Gao, Huaxin Li, Mei Yuan
Summary: This case report describes a female patient with both cobalamin C (cblC) disease and Kallmann syndrome (KS). Clinical and genetic examinations confirmed the diagnoses of both diseases, enriching the clinical research on these rare genetic disorders. The coexistence of cblC disease and KS caused by different pathogenic genes in a single patient is a novel finding.
METABOLIC BRAIN DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Xianmei Gou, Lin Qin, Di Wu, Jian Xie, Yanliu Lu, Qianru Zhang, Yuqi He
Summary: Bile acids are recognized as signaling molecules involved in metabolic syndrome, and Takeda G protein-coupled receptor 5 (TGR5) acts as a significant receptor for bile acids, which is associated with lipid homeostasis, glucose metabolism, and inflammation regulation. Recent preclinical studies suggest that TGR5 plays a crucial role in the generation and progression of metabolic syndrome, including type 2 diabetes mellitus, obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). This review discusses the role of TGR5 in metabolic syndrome, highlighting the underlying mechanisms and therapeutic targets.
Review
Cell Biology
Haoran Jiang, Daniella Galtes, Jialu Wang, Howard A. Rockman
Summary: This review explores the signaling pathways, dynamic structures, and physiological relevance of the three most important GPCR signaling effectors in the cardiovascular system: heterotrimeric G proteins, GPCR kinases (GRKs), and 8-arrestins. It summarizes their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. The application of new technologies has contributed to an increasing understanding of GPCR structure and downstream effectors.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Estefania Moreno, Nil Casajuana-Martin, Michael Coyle, Baruc Campos Campos, Ewa Galaj, Claudia Llinas del Torrent, Arta Seyedian, William Rea, Ning-Sheng Cai, Alessandro Bonifazi, Benjamin Floran, Zheng-Xiong Xi, Xavier Guitart, Vicent Casado, Amy H. Newman, Christopher Bishop, Leonardo Pardo, Sergi Ferre
Summary: This study provides evidence that heteromerization of G protein-coupled receptors (GPCRs), specifically dopamine D1 and D3 receptors, can influence the pharmacological properties of selective ligands. In vivo experiments support the involvement of D1R-D3R heteromers in the development of L-DOPA-induced dyskinesia in Parkinson's disease, suggesting the potential of targeting GPCR heteromers for drug development.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juergen Einsiedel, Maximilian F. Schmidt, Harald Huebner, Peter Gmeiner
Summary: A broadly applicable synthesis method was developed for peptides incorporating mixed disulfides between cysteine and homocysteine and cysteamine. The method was successfully applied to pharmacologically relevant GPCR ligands and showed covalent binding to neurotensin receptor 1 in a radioligand depletion study.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May
Summary: Heart failure remains a significant cause of morbidity and mortality worldwide. Current treatment options have limitations, leading to many patients progressing to advanced stages. Exploration of novel therapeutics targeting G protein-coupled receptors (GPCRs) has shown promise, but efficacy and unwanted effects remain as challenges.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mydirah Littlepage-Saunders, Michael J. Hochstein, Doris S. Chang, Kari A. Johnson
Summary: Dopamine transmission in the striatum is regulated by various G protein-coupled receptors (GPCRs) that bind neuromodulators, including dopamine itself. These GPCRs can modulate dopamine release by acting on different components of the dopaminergic circuitry and can have distinct effects on behavior and psychoactive drug actions. This review discusses the mechanisms by which GPCRs regulate dopaminergic transmission and their relevance to the effects of psychoactive drugs on physiology and behavior.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Damian Jacenik, Pawel Hikisz, Ellen J. Beswick, Jakub Fichna
Summary: Among the various adhesion G protein-coupled receptors, ADGRF5 stands out with its unique domains in the N-terminal tail that play a critical role in cell-cell and cell-matrix interactions, as well as cell adhesion. Although the biology of ADGRF5 is still not fully understood, accumulating evidence suggests its fundamental importance in both health and disease. Recent studies have highlighted its potential diagnostic value in osteoporosis and cancers, and ongoing research indicates its relevance to other diseases as well. This article provides a comprehensive overview of the current understanding of ADGRF5 in human disease physiology and pathophysiology, emphasizing its potential as a novel therapeutic target in various areas.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Raudah Lazim, Donghyuk Suh, Jai Woo Lee, Thi Ngoc Lan Vu, Sanghee Yoon, Sun Choi
Summary: The presence of GPCR dimers has sparked research into their importance in disease pathogenesis and drug design, uncovering new signaling pathways and potential therapeutic targets. The increasing influence of computational methods in research is providing new avenues for understanding the functions and interactions of GPCRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Alastair C. Keen, Manuela Jorg, Michelle L. L. Halls
Summary: The ubiquitin-proteasome system is a major pathway for protein degradation in cells, and methods have been developed to exploit this system for targeted protein degradation. Targeted protein degraders have been useful tools in discovery research and are being developed as therapeutics. However, most targeted protein degrader technologies have been developed for cytosolic proteins, while examples for G protein-coupled receptor (GPCR) degradation are limited. This review discusses the strategies used for applying targeted protein degradation to GPCRs and explores alternative approaches used for degrading other integral membrane proteins.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhengxin Chen, Shuai Wang, Hai-Lin Li, Hui Luo, Xiaoting Wu, Jiacheng Lu, Hong-Wei Wang, Yuanyuan Chen, Dan Chen, Wen-Ting Wu, Shuyu Zhang, Qiongqiong He, Daru Lu, Ning Liu, Yongping You, Wei Wu, Huibo Wang
Summary: FOSL1 is a key player in regulating the proneural to mesenchymal transition (PMT) in glioblastoma stem cells (GSCs). It promotes the ionizing radiation-induced PMT and radioresistance of Proneural GSCs. Mechanistically, FOSL1 induces PMT by promoting UBC9-dependent CYLD SUMOylation and subsequent NF-kappa B activation. Therapeutic targeting of FOSL1 holds promise to attenuate molecular subtype switching in glioblastoma patients.
Article
Optics
Dan Chen, Yanrong Liu, Feier Ai, Minghua Cao
Summary: The pulse response expression of the non-line-of-sight underwater laser channel is derived based on the binomial Henyey-Greenstein scattering phase function, considering the forward and backward effects. The effectiveness of the established underwater photon transmission channel model is simulated and verified, showing better fitting effects in coastal waters. The pulse-broadening factor is higher in coastal waters compared to harbor waters, and the time-domain broadening effect of laser pulse transmission is significant in harbor waters, particularly influenced by front scattering when the asymmetry factor is large.
OPTICAL ENGINEERING
(2022)
Article
Mechanics
Danyang Chen, Zhideng Zhou, Xiaolei Yang
Summary: A novel MCPNN-frozen model is proposed in this study for wind resource assessment, utilizing neural networks and frozen flow hypothesis. Results indicate the model performs well under certain conditions.
Article
Multidisciplinary Sciences
Yingwen Hu, Danyang Chen, John Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A. Savran, Philip S. Low
Summary: The combination of folate-biotin conjugates and magnetic beads can efficiently capture tumor cells, which has been validated in both mouse models and non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Electrical & Electronic
Yulong Dong, Danyang Chen, Ni Zhong, Jingquan Liu, Chungang Duan, Xiuyan Li
Summary: This article presents an electrostatic model to explain the negative capacitance (NC) effects in ferroelectric (FE) films, and explores the occurrence of NC effects in a specific time window through experimental studies. The key factor determining this time window is the competition between FE switching and charge compensation.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Acoustics
Dandan Chen, Juan Xia, Shurui Xie, Yafeng He, Xiaojing Ma
Summary: This case report highlights the successful diagnosis and treatment of a rare case of unruptured right SOVA using transthoracic echocardiography, contrastive echocardiography, and transesophageal echocardiography.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Chemistry, Analytical
Shen Wang, Yingcui Bu, Xin Lu, Dandan Chen, Zhipeng Yu, Jie Zhang, Lianke Wang, Hongping Zhou
Summary: A specifically cancer cell lysosome targeted pre-photosensitizer with suitable pH-response range has been designed and applied for switch-on photodynamic therapy. The experiments on mice model showed that the pre-photosensitizer is inactive in normal tissue and active in tumor region.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Xu Zhou, Zhiqun Xie, Jian He, Hong Lin, Juan Xiao, Hua Wang, Junqun Fang, Jie Gao
Summary: This study aimed to describe the epidemiological characteristics of injury-related mortality rates in children under five in Hunan Province, China. The findings revealed that injury-related deaths were mainly caused by drowning, suffocation, traffic injuries, falls, and poisoning. The study highlights the importance of implementing intervention programs to reduce injury-related deaths among children.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Zenghui Xu, Lili Xiong, Mengjun Zeng, Aihua Wang, Zhiqun Xie, Donghua Xie, Jian He, Xinjun Hua, Xu Zhou
Summary: This study examines the effects of air pollutants on maternal preeclampsia and sub-types in a rural area of China. It finds that exposure to PM2.5 is associated with mild preeclampsia, while exposure to ozone has the opposite effect. SO2 exposure in the third trimester is positively associated with mild preeclampsia. Season and parity also influence the relationship between pollutants and preeclampsia.
ATMOSPHERIC POLLUTION RESEARCH
(2023)
Correction
Oncology
Su Deng, Choushi Wang, Yunguan Wang, Yaru Xu, Xiaoling Li, Nickolas A. Johnson, Atreyi Mukherji, U-Ging Lo, Lingfan Xu, Julisa Gonzalez, Lauren A. Metang, Jianfeng Ye, Carla Rodriguez Tirado, Kathia Rodarte, Yinglu Zhou, Zhiqun Xie, Carlos Arana, Valli Annamalai, Xihui Liu, Donald J. Vander Griend, Douglas Strand, Jer-Tsong Hsieh, Bo Li, Ganesh Raj, Tao Wang, Ping Mu
Article
Oncology
Su Deng, Choushi Wang, Yunguan Wang, Yaru Xu, Xiaoling Li, Nickolas A. Johnson, Atreyi Mukherji, U-Ging Lo, Lingfan Xu, Julisa Gonzalez, Lauren A. Metang, Jianfeng Ye, Carla Rodriguez Tirado, Kathia Rodarte, Yinglu Zhou, Zhiqun Xie, Carlos Arana, Valli Annamalai, Xihui Liu, Donald J. Vander Griend, Douglas Strand, Jer-Tsong Hsieh, Bo Li, Ganesh Raj, Tao Wang, Ping Mu
Summary: The JAK-STAT signaling pathway plays a crucial role in promoting lineage plasticity-driven resistance to androgen receptor-targeted therapy in prostate cancer. Targeting JAK-STAT proteins may help overcome this resistance and resensitize tumors to therapy.
Article
Optics
Wang Mingjun, Wang Yuhang, Chen Dan, Zhang Jialin, Li Jianqing
Summary: This study investigates the transmission characteristics of blue-green laser across the air-sea cross-medium by developing a transmission model. Factors such as wind speed, bubble concentration, and mixing of bubbles in seawater are considered. The results show that wind speed and transmission depth are key factors affecting laser transmittance, and the effect of the bubble layer decreases with depth.
ACTA OPTICA SINICA
(2022)
Article
Materials Science, Biomaterials
Limin Chang, Ruixue Chang, Xiaojun Liu, Xiangbo Ma, Danyang Chen, Yong Wang, Wenjuan Li, Jianglei Qin
Summary: In this study, a pectin-based self-healing hydrogel was developed with conjugated polyphosphate for effective hemostasis and wound healing. The hydrogel exhibited self-healing property and sustained release performance, leading to accelerated blood coagulation and wound repair. Moreover, it also prevented bacterial invasion.
BIOMATERIALS ADVANCES
(2022)
Article
Engineering, Electrical & Electronic
Cao Minghua, Wu Zhaoheng, Zhang Wei, Qiu Yan, Xia Jieping, Chen Dan, Wang Huiqin
Summary: In this paper, a hybrid modulated faster-than-Nyquist (PSK-PPM-FTN) rate atmospheric optical communication scheme is proposed, which combines phase-shift keying (PSK) and pulse-position modulation (PPM) to improve the bandwidth utilization and data transmission rate of the system.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Article
Astronomy & Astrophysics
Homare Abe, Tomotada Akutsu, Masaki Ando, Akito Araya, Naoki Aritomi, Hideki Asada, Yoichi Aso, Sangwook Bae, Rishabh Bajpai, Kipp Cannon, Zhoujian Cao, Eleonora Capocasa, Man Leong Chan, Dan Chen, Yi-Ru Chen, Marc Eisenmann, Raffaele Flaminio, Heather K. Fong, Yuta Fujikawa, Yuya Fujimoto, I. Putu Wira Hadiputrawan, Sadakazu Haino, Wenbiao Han, Kazuhiro Hayama, Yoshiaki Himemoto, Naoatsu Hirata, Chiaki Hirose, Tsung-Chieh Ho, Bin-Hua Hsieh, He-Feng Hsieh, Chia-Hsuan Hsiung, Hsiang-Yu Huang, Panwei Huang, Yao-Chin Huang, Yun-Jing Huang, David C. Y. Hui, Kohei Inayoshi, Yuki Inoue, Yousuke Itoh, Pil-Jong Jung, Takaaki Kajita, Masahiro Kamiizumi, Nobuyuki Kanda, Takashi Kato, Chunglee Kim, Jaewan Kim, Young-Min Kim, Yuichiro Kobayashi, Kazunori Kohri, Keiko Kokeyama, Albert K. H. Kong, Naoki Koyama, Chihiro Kozakai, Jun'ya Kume, Sachiko Kuroyanagi, Kyujin Kwak, Eunsub Lee, Hyung Won Lee, Ray-Kuang Lee, Matteo Leonardi, Kwan-Lok Li, Pengbo Li, Lupin Chun-Che Lin, Chun-Yu Lin, En-Tzu Lin, Hong-Lin Lin, Guo-Chin Liu, Ling-Wei Luo, Miftahul Ma'arif, Yuta Michimura, Norikatsu Mio, Osamu Miyakawa, Kouseki Miyo, Shinji Miyoki, Nozomi Morisue, Kouji Nakamura, Hiroyuki Nakano, Masayuki Nakano, Tatsuya Narikawa, Lan Nguyen Quynh, Takumi Nishimoto, Atsushi Nishizawa, Yoshihisa Obayashi, Kwangmin Oh, Masatake Ohashi, Tomoya Ohashi, Masashi Ohkawa, Yoshihiro Okutani, Ken-ichi Oohara, Shoichi Oshino, Kuo-Chuan Pan, Alessandro Parisi, June Gyu Park, Fabian E. Pena Arellano, Surojit Saha, Kazuki Sakai, Takahiro Sawada, Yuichiro Sekiguchi, Lijing Shao, Yutaka Shikano, Hirotaka Shimizu, Katsuhiko Shimode, Hisaaki Shinkai, Ayaka Shoda, Kentaro Somiya, Inhyeok Song, Ryosuke Sugimoto, Jishnu Suresh, Takamasa Suzuki, Takanori Suzuki, Toshikazu Suzuki, Hideyuki Tagoshi, Hirotaka Takahashi, Ryutaro Takahashi, Hiroki Takeda, Mei Takeda, Atsushi Taruya, Takayuki Tomaru, Tomonobu Tomura, Lucia Trozzo, Terrence T. L. Tsang, Satoshi Tsuchida, Takuya Tsutsui, Darkhan Tuyenbayev, Nami Uchikata, Takashi Uchiyama, Tomoyuki Uehara, Koh Ueno, Takafumi Ushiba, Maurice H. P. M. van Putten, Tatsuki Washimi, Chien-Ming Wu, Hsun-Chung Wu, Tomohiro Yamada, Kazuhiro Yamamoto, Takahiro Yamamoto, Ryo Yamazaki, Shu-Wei Yeh, Jun'ichi Yokoyama, Takaaki Yokozawa, Hirotaka Yuzurihara, Simon Zeidler, Yuhang Zhao
Summary: KAGRA is a gravitational-wave detector in Japan with unique features of underground construction and cryogenic cooling. Although its sensitivity to gravitational waves is inferior to other detectors like LIGO and Virgo, further upgrades are being conducted to improve its sensitivity for the next observation run in 2022.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)