A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling

G-protein inhibition profile of the reported G q/11 inhibitor UBO-QIC

(2016) Jyrki P. Kukkonen   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

(2016) Katie Leach et al.   CELL RESEARCH

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

(2016) Valerie N. Babinsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A G-protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)

(2016) Caroline M Gorvin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain

(2016) Yanting Yin et al.   Cell Discovery

The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1)

(2015) Fadil M. Hannan et al.   ENDOCRINOLOGY

Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype–phenotype correlations, codon bias and dominant-negative effects

(2015) Fadil M. Hannan et al.   HUMAN MOLECULAR GENETICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor

(2014) Mahvash A. Goolam et al.   FEBS LETTERS

Autosomal Dominant Hypoparathyroidism Caused by Germline Mutation inGNA11: Phenotypic and Molecular Characterization

(2014) Dong Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

Role of Ca2+ and L-Phe in Regulating Functional Cooperativity of Disease-Associated “Toggle” Calcium-Sensing Receptor Mutations

(2014) Chen Zhang et al.   PLoS One

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells

(2013) Vimesh A. Avlani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of the calcium-sensing receptor in extracellular calcium homeostasis

(2013) Edward M. Brown   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators

(2013) Katie Leach et al.   ENDOCRINOLOGY

p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner

(2013) Zhipeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia

(2013) M. Andrew Nesbit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant Prolactin Receptor and Familial Hyperprolactinemia

(2013) Paul J. Newey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor

(2012) Katie Leach et al.   ENDOCRINOLOGY

Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites

(2012) F. M. Hannan et al.   HUMAN MOLECULAR GENETICS

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3

(2012) M Andrew Nesbit et al.   NATURE GENETICS

Biased agonism of the calcium-sensing receptor

(2011) Alex Rojas Bie Thomsen et al.   CELL CALCIUM

Activating mutations in the calcium-sensing receptor: genetic and clinical spectrum in 25 patients with autosomal dominant hypocalcaemia - a German survey

(2011) Friedhelm Raue et al.   CLINICAL ENDOCRINOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants

(2009) Elissa White et al.   MOLECULAR ENDOCRINOLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and β-arrestin interaction

(2007) Kyeong-Man Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS