Mesenchymal Stem Cell-Derived Extracellular Vesicles: Opportunities and Challenges for Clinical Translation
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Title
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Opportunities and Challenges for Clinical Translation
Authors
Keywords
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Journal
Frontiers in Bioengineering and Biotechnology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-09-10
DOI
10.3389/fbioe.2020.00997
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Note: Only part of the references are listed.- Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure
- (2020) Patricia van den Hoogen et al. PLoS One
- Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
- (2020) Maria Laggner et al. Stem Cell Research & Therapy
- Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing
- (2020) Juan Fafián-Labora et al. Stem Cell Research & Therapy
- Low dose of extracellular vesicles identified that promote recovery after ischemic stroke
- (2020) Laura Otero-Ortega et al. Stem Cell Research & Therapy
- Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging
- (2020) Jérémy Boulestreau et al. Frontiers in Cell and Developmental Biology
- The Secretome Derived From Mesenchymal Stromal Cells Cultured in a Xeno-Free Medium Promotes Human Cartilage Recovery in vitro
- (2020) Maria Elisabetta Federica Palamà et al. Frontiers in Bioengineering and Biotechnology
- Human Mesenchymal Stromal Cell Source and Culture Conditions Influence Extracellular Vesicle Angiogenic and Metabolic Effects on Human Endothelial Cells In Vitro
- (2020) Tiffani C. Chance et al. Journal of Trauma and Acute Care Surgery
- Extracellular vesicles derived from microRNA-150-5p-overexpressing mesenchymal stem cells protect rat hearts against ischemia/reperfusion
- (2020) Hesheng Ou et al. Aging-US
- Exosomes derived from miRNA-210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF-κB pathway
- (2020) Lei He et al. GENE
- Extracellular Microvesicles as New Industrial Therapeutic Frontiers
- (2019) Vivek Agrahari et al. TRENDS IN BIOTECHNOLOGY
- Mesenchymal Stromal Cell Derived Extracellular Vesicles Reduce Hypoxia-Ischaemia Induced Perinatal Brain Injury
- (2019) Claudia Sisa et al. Frontiers in Physiology
- A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells
- (2019) Claire Mennan et al. Stem Cell Research & Therapy
- “Exosomes on the border of species and kingdom intercommunication”
- (2019) Christina M.A.P. Schuh et al. Translational Research
- Freeze-dried and GMP-compliant pharmaceuticals containing exosomes for acellular mesenchymal stromal cell immunomodulant therapy
- (2019) Elia Bari et al. Nanomedicine
- Scalable production and isolation of extracellular vesicles: available sources and lessons from current industrial bioprocesses
- (2019) Carolina Paganini et al. Biotechnology Journal
- Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing
- (2019) Eva Rohde et al. CYTOTHERAPY
- A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains
- (2019) María Eugenia Zurita et al. Frontiers in Cellular and Infection Microbiology
- Effect of Storage Conditions on the Integrity of Human Umbilical Cord Mesenchymal Stromal Cell-Derived Microvesicles
- (2019) Yu. A. Romanov et al. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
- Targeted delivery of doxorubicin to HER2 positive tumor models
- (2019) Hosna Gomari et al. International Journal of Nanomedicine
- Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury
- (2019) Ruoqiong Huang et al. Aging-US
- Mesenchymal stem/stromal cell secretome for lung regeneration: The long way through “pharmaceuticalization” for the best formulation
- (2019) Elia Bari et al. JOURNAL OF CONTROLLED RELEASE
- Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment
- (2019) Yoda Yaghoubi et al. LIFE SCIENCES
- Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
- (2019) Kyong-Su Park et al. Stem Cell Research & Therapy
- Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration
- (2019) Bari et al. Cells
- A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro
- (2019) Hongxiang Wei et al. International Journal of Nanomedicine
- Functional proteins of mesenchymal stem cell-derived extracellular vesicles
- (2019) Guanguan Qiu et al. Stem Cell Research & Therapy
- Immunotherapy Based on Dendritic Cell-Targeted/-Derived Extracellular Vesicles—A Novel Strategy for Enhancement of the Anti-tumor Immune Response
- (2019) Oleg Markov et al. Frontiers in Pharmacology
- Sustained Delivery System for Stem Cell-Derived Exosomes
- (2019) Andri K. Riau et al. Frontiers in Pharmacology
- Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review
- (2019) Daniele D’Arrigo et al. Journal of Clinical Medicine
- Targeting the Immune System With Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo's Mechanism of Action?
- (2019) Jorge Diego Martin-Rufino et al. Frontiers in Bioengineering and Biotechnology
- Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction
- (2019) Sarah Le Saux et al. BIOMATERIALS
- Large-Scale Automated Hollow-Fiber Bioreactor Expansion of Umbilical Cord-Derived Human Mesenchymal Stromal Cells for Neurological Disorders
- (2019) Ladislava Vymetalova et al. NEUROCHEMICAL RESEARCH
- LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis
- (2019) Qing Mao et al. Stem Cell Research & Therapy
- Preparation of Engineered Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells with Ultrasonication for Skin Rejuvenation
- (2019) Lixue Wang et al. ACS Omega
- MSC exosome works through a protein-based mechanism of action
- (2018) Wei Seong Toh et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
- (2018) Tian Tian et al. BIOMATERIALS
- Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice
- (2018) Guo-Hong Cui et al. FASEB JOURNAL
- Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity
- (2018) Tomas Fiedler et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Extracellular vesicles have variable dose-dependent effects on cultured draining cells in the eye
- (2018) Saray Tabak et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Shedding light on the cell biology of extracellular vesicles
- (2018) Guillaume van Niel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents
- (2018) Zahra Abbasi-Malati et al. Stem Cell Reviews and Reports
- Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem Cells Enhance Angiogenesis Through the PKA Signaling Pathway
- (2018) Chunling Xue et al. STEM CELLS AND DEVELOPMENT
- Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote lung adenocarcinoma growth by transferring miR-410
- (2018) Liyang Dong et al. Cell Death & Disease
- Establishment of xenogeneic serum-free culture methods for handling human dental pulp stem cells using clinically oriented in-vitro and in-vivo conditions
- (2018) Mai Mochizuki et al. Stem Cell Research & Therapy
- Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
- (2018) Somayeh Keshtkar et al. Stem Cell Research & Therapy
- Exosome Theranostics: Biology and Translational Medicine
- (2018) Chuanjiang He et al. Theranostics
- Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
- (2018) Stella Cosenza et al. Theranostics
- Mesenchymal Stem Cells on Horizon: A New Arsenal of Therapeutic Agents
- (2018) Zahra Abbasi-Malati et al. Stem Cell Reviews and Reports
- Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A
- (2018) Guping Mao et al. Stem Cell Research & Therapy
- Extracellular vesicles for personalized medicine: The input of physically triggered production, loading and theranostic properties
- (2018) Max Piffoux et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2018) Chonlada Charoenviriyakul et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
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- (2018) Gina D. Kusuma et al. Frontiers in Pharmacology
- Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process
- (2018) Elia Bari et al. Cells
- Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species
- (2018) A.J. Villatoro et al. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
- Enhanced Cell Growth of Adipocyte-Derived Mesenchymal Stem Cells Using Chemically-Defined Serum-Free Media
- (2017) Myung-Suk Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Manufacturing of Human Extracellular Vesicle-Based Therapeutics for Clinical Use
- (2017) Mario Gimona et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Stem cell-extracellular vesicles as drug delivery systems: New frontiers for silk/curcumin nanoparticles
- (2017) Sara Perteghella et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication
- (2017) Daniel J. Schneider et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury
- (2017) Marilena Gregorini et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system
- (2017) Barbara Crivelli et al. JOURNAL OF CONTROLLED RELEASE
- Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus
- (2017) Qianfa Long et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells
- (2017) Rohan Kulkarni et al. STEM CELLS
- Effect of age on pro-inflammatory miRNAs contained in mesenchymal stem cell-derived extracellular vesicles
- (2017) J. Fafián-Labora et al. Scientific Reports
- Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis
- (2017) Stella Cosenza et al. Scientific Reports
- Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure
- (2017) Lu Chen et al. Stem Cell Research & Therapy
- Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?
- (2017) Paul Lohan et al. Frontiers in Immunology
- Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis
- (2017) Lingling Bai et al. Scientific Reports
- Administration of bone marrow stromal cells in sepsis attenuates sepsis-related coagulopathy
- (2016) Lifei Tan et al. ANNALS OF MEDICINE
- Efficient production and enhanced tumor delivery of engineered extracellular vesicles
- (2016) Dionysios C. Watson et al. BIOMATERIALS
- Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases
- (2016) Antoine Monsel et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles
- (2016) Marie-Theres Zeuner et al. Journal of Translational Medicine
- Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia
- (2016) Daan R.M.G. Ophelders et al. Stem Cells Translational Medicine
- Towards Therapeutic Delivery of Extracellular Vesicles: Strategies forIn VivoTracking and Biodistribution Analysis
- (2016) Giuliana Di Rocco et al. Stem Cells International
- Antifibrotic, Antioxidant, and Immunomodulatory Effects of Mesenchymal Stem Cells in HOCl-Induced Systemic Sclerosis
- (2016) Alexandre T. J. Maria et al. Arthritis & Rheumatology
- Trehalose prevents aggregation of exosomes and cryodamage
- (2016) Steffi Bosch et al. Scientific Reports
- Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice
- (2015) Antoine Monsel et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
- (2015) Yanlu Zhang et al. JOURNAL OF NEUROSURGERY
- LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b
- (2015) Dongdong Ti et al. Journal of Translational Medicine
- Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
- (2015) Serena Rubina Baglio et al. Stem Cell Research & Therapy
- Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
- (2015) Thorsten R. Doeppner et al. Stem Cells Translational Medicine
- Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle
- (2014) Cecilia Lässer EXPERT OPINION ON BIOLOGICAL THERAPY
- MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease
- (2014) L Kordelas et al. LEUKEMIA
- Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models
- (2014) Cheau Tan et al. Stem Cell Research & Therapy
- Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
- (2014) Justin D Glenn World Journal of Stem Cells
- Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes
- (2013) Marie Maumus et al. BIOCHIMIE
- Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats
- (2013) Hongqi Xin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
- (2013) Suyan Bian et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis
- (2013) Carlos Salomon et al. PLoS One
- Concise Review: MicroRNA Function in Multipotent Mesenchymal Stromal Cells
- (2013) Elizabeth A. Clark et al. STEM CELLS
- Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice
- (2013) Ying-gang Zhu et al. STEM CELLS
- Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis
- (2012) Tingfen Li et al. STEM CELLS AND DEVELOPMENT
- Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs
- (2011) Tian Chen et al. Journal of Translational Medicine
- Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements
- (2011) Joyce Doorn et al. TISSUE ENGINEERING PART B-REVIEWS
- Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
- (2010) Ruenn Chai Lai et al. Stem Cell Research
- Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
- (2009) S. Bruno et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Membrane-based techniques for the separation and purification of proteins: An overview
- (2008) Arunima Saxena et al. ADVANCES IN COLLOID AND INTERFACE SCIENCE
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